SMURF2 Facilitates GAP17 Isoform 1 Membrane Displacement to Promote Mutant p53-KRAS Oncogenic Synergy.
Ray P, Shukla S, Zhang Y, Donahue KL, Nancarrow DJ, Kasturirangan S, Shankar S, Cuneo K, Thomas D, Gadgeel SM, Lawrence TS, Pasca di Magliano M, Ray D.
Ray P, et al.
Mol Cancer Res. 2025 Jun 3;23(6):530-541. doi: 10.1158/1541-7786.MCR-24-0701.
Mol Cancer Res. 2025.
PMID: 39976545
Free PMC article.
We found that SMURF2 silencing profoundly reduces the survival of mutant TP53; KRAS-driven cells. We show that a GAP17-1 AALA mutant does not bind to SMURF2, stays in the membrane, and keeps mutant KRAS in the GDP-bound state to inhibit downstream signaling. ...
We found that SMURF2 silencing profoundly reduces the survival of mutant TP53; KRAS-driven cells. We show that a GAP17-1 AALA mutant …