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41 results

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The neuroimmune axis of Alzheimer's disease.
Jorfi M, Maaser-Hecker A, Tanzi RE. Jorfi M, et al. Genome Med. 2023 Jan 26;15(1):6. doi: 10.1186/s13073-023-01155-w. Genome Med. 2023. PMID: 36703235 Free PMC article. Review.
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with multifaceted neuropathological features, including beta-amyloid plaques, neurofibrillary tangles, and neuroinflammation. ...
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with multifaceted neuropathological features, including …
Infiltrating CD8(+) T cells exacerbate Alzheimer's disease pathology in a 3D human neuroimmune axis model.
Jorfi M, Park J, Hall CK, Lin CJ, Chen M, von Maydell D, Kruskop JM, Kang B, Choi Y, Prokopenko D, Irimia D, Kim DY, Tanzi RE. Jorfi M, et al. Nat Neurosci. 2023 Sep;26(9):1489-1504. doi: 10.1038/s41593-023-01415-3. Epub 2023 Aug 24. Nat Neurosci. 2023. PMID: 37620442 Free PMC article.
Brain infiltration of peripheral immune cells and their interactions with brain-resident cells may contribute to Alzheimer's disease (AD) pathology. To examine these interactions, in the present study we developed a three-dimensional human neuroimmune axis model comprising …
Brain infiltration of peripheral immune cells and their interactions with brain-resident cells may contribute to Alzheimer's disease …
Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease.
McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK. McAlpine CS, et al. Nature. 2021 Jul;595(7869):701-706. doi: 10.1038/s41586-021-03734-6. Epub 2021 Jul 14. Nature. 2021. PMID: 34262178 Free PMC article.
The influence of glial cells on the accumulation and clearance of beta-amyloid (Abeta) and neurofibrillary tau in the brains of individuals with Alzheimer's disease (AD) is poorly understood, despite growing awareness that these are therapeutically important interactions(4 …
The influence of glial cells on the accumulation and clearance of beta-amyloid (Abeta) and neurofibrillary tau in the brains of individuals …
Approaches for studying neuroimmune interactions in Alzheimer's disease.
Lin C', Tian Y, Tanzi RE, Jorfi M. Lin C', et al. Trends Immunol. 2024 Dec;45(12):971-986. doi: 10.1016/j.it.2024.10.002. Epub 2024 Nov 12. Trends Immunol. 2024. PMID: 39537528 Review.
Peripheral immune cells play an important role in the pathology of Alzheimer's disease (AD), impacting processes such as amyloid and tau protein aggregation, glial activation, neuronal integrity, and cognitive decline. ...
Peripheral immune cells play an important role in the pathology of Alzheimer's disease (AD), impacting processes such as amyloid and …
Beyond the sleep-amyloid interactions in Alzheimer's disease pathogenesis.
Ning S, Jorfi M. Ning S, et al. J Neurophysiol. 2019 Jul 1;122(1):1-4. doi: 10.1152/jn.00118.2019. Epub 2019 Mar 13. J Neurophysiol. 2019. PMID: 30864847 Free article. Review.
Numerous studies have linked disrupted sleep and circadian rhythms with amyloid-beta (Abeta), a key pathological hallmark in Alzheimer's disease (AD). While previous evidence suggests that Abeta initiates AD pathogenesis, tau, another major hallmark of AD, seems to drive n …
Numerous studies have linked disrupted sleep and circadian rhythms with amyloid-beta (Abeta), a key pathological hallmark in Alzheimer's …
The interplay between microglial states and major risk factors in Alzheimer's disease through the eyes of single-cell RNA-sequencing: beyond black and white.
von Maydell D, Jorfi M. von Maydell D, et al. J Neurophysiol. 2019 Oct 1;122(4):1291-1296. doi: 10.1152/jn.00395.2019. Epub 2019 Jul 31. J Neurophysiol. 2019. PMID: 31365320 Free article. Review.
This spectrum spans heterogeneous populations of homeostatic and neuropathology-associated microglia in both healthy and Alzheimer's disease (AD) mouse brains. Major risk factors, such as sex, age, and genes, modulate microglial states, suggesting that shifts along the tra …
This spectrum spans heterogeneous populations of homeostatic and neuropathology-associated microglia in both healthy and Alzheimer's …
Patterning of interconnected human brain spheroids.
Kim JJ, Jorfi M, Tanzi RE, Kim DY, Doyle PS, Irimia D. Kim JJ, et al. Lab Chip. 2021 Sep 14;21(18):3532-3540. doi: 10.1039/d0lc01112f. Lab Chip. 2021. PMID: 34286713 Free PMC article.
Brain spheroids are emerging as valuable in vitro models that are accelerating the pace of research in various diseases. For Alzheimer's disease (AD) research, these models are enhanced using genetically engineered human neural progenitor cells and novel cell culture metho …
Brain spheroids are emerging as valuable in vitro models that are accelerating the pace of research in various diseases. For Alzheimer's …
Three-Dimensional Models of the Human Brain Development and Diseases.
Jorfi M, D'Avanzo C, Kim DY, Irimia D. Jorfi M, et al. Adv Healthc Mater. 2018 Jan;7(1):10.1002/adhm.201700723. doi: 10.1002/adhm.201700723. Epub 2017 Aug 28. Adv Healthc Mater. 2018. PMID: 28845922 Free PMC article. Review.
Recently, advances in the development of three-dimensional (3D) brain cell culture models have begun to recapitulate various aspects of the human brain physiology in vitro and replicate basic disease processes of Alzheimer's disease, amyotrophic lateral sclerosis, and micr …
Recently, advances in the development of three-dimensional (3D) brain cell culture models have begun to recapitulate various aspects of the …
Human Neurospheroid Arrays for In Vitro Studies of Alzheimer's Disease.
Jorfi M, D'Avanzo C, Tanzi RE, Kim DY, Irimia D. Jorfi M, et al. Sci Rep. 2018 Feb 5;8(1):2450. doi: 10.1038/s41598-018-20436-8. Sci Rep. 2018. PMID: 29402979 Free PMC article.
We also cultivate genetically-engineered stem cell-derived neurospheroids with familial Alzheimer's disease mutations for eight weeks in our microarray system. Interestingly, we observed robust accumulation of amyloid-beta and phosphorylated tau, key hallmarks of Alzheimer …
We also cultivate genetically-engineered stem cell-derived neurospheroids with familial Alzheimer's disease mutations for eight weeks …
41 results