12-Hydroxyeicosatetraenoic acid is the only enzymatically produced HETE increased under brain ischemia.
Golovko MY, Seeger DR, Schofield B, Besch D, Kotha P, Mansouripour A, Solaymani-Mohammadi S, Golovko SA.
Golovko MY, et al.
Prostaglandins Leukot Essent Fatty Acids. 2024 Mar;202:102631. doi: 10.1016/j.plefa.2024.102631. Epub 2024 Jul 19.
Prostaglandins Leukot Essent Fatty Acids. 2024.
PMID: 39059107
Free PMC article.
Consistent with previous reports, we demonstrated a significant, gradual increase in all analyzed HETE over 10 min of brain ischemia, likely attributed to release of the esterified pool. The R/S ratio for 5-HETE, 8-HETE, and 15-HETE was not different from a racemic standar …
Consistent with previous reports, we demonstrated a significant, gradual increase in all analyzed HETE over 10 min of brain ischemia, likely …