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Androgen deprivation induces neuroendocrine phenotypes in prostate cancer cells through CREB1/EZH2-mediated downregulation of REST.
Zheng D, Zhang Y, Yang S, Su N, Bakhoum M, Zhang G, Naderinezhad S, Mao Z, Wang Z, Zhou T, Li W. Zheng D, et al. Cell Death Discov. 2024 May 22;10(1):246. doi: 10.1038/s41420-024-02031-1. Cell Death Discov. 2024. PMID: 38777812 Free PMC article.
Finally, genetic rescue experiments demonstrated that ADT induces NED through EZH2's repression of REST, which is enhanced by ADT-activated CREB1 signaling. In summary, our study has revealed a key pathway underlying NE gene upregulation by ADT, as well as established nove …
Finally, genetic rescue experiments demonstrated that ADT induces NED through EZH2's repression of REST, which is enhanced by ADT-act …
A novel GRK3-HDAC2 regulatory pathway is a key direct link between neuroendocrine differentiation and angiogenesis in prostate cancer progression.
Naderinezhad S, Zhang G, Wang Z, Zheng D, Hulsurkar M, Bakhoum M, Su N, Yang H, Shen T, Li W. Naderinezhad S, et al. Cancer Lett. 2023 Sep 1;571:216333. doi: 10.1016/j.canlet.2023.216333. Epub 2023 Aug 4. Cancer Lett. 2023. PMID: 37543278 Free PMC article.
Of note, GRK3 phosphorylates HDAC2 at S394, which enhances HDAC2's epigenetic repression of potent anti-angiogenic factor Thrombospondin 1 (TSP1) and master NE-repressor RE1 Silencing Transcription Factor (REST). ...
Of note, GRK3 phosphorylates HDAC2 at S394, which enhances HDAC2's epigenetic repression of potent anti-angiogenic factor Thrombospon …
Androgen deprivation induces neuroendocrine phenotypes in prostate cancer cells through CREB1/EZH2-mediated downregulation of REST.
Li W, Zheng D, Zhang Y, Yang S, Su N, Bakhoum M, Zhang G, Naderinezhad S, Mao Z, Wang Z, Zhou T. Li W, et al. Res Sq [Preprint]. 2023 Oct 4:rs.3.rs-3270539. doi: 10.21203/rs.3.rs-3270539/v1. Res Sq. 2023. Update in: Cell Death Discov. 2024 May 22;10(1):246. doi: 10.1038/s41420-024-02031-1. PMID: 37886478 Free PMC article. Updated. Preprint.
Finally, genetic rescue experiments demonstrated that ADT induces NED through EZH2's repression of REST, which is enhanced by ADT-activated CREB signaling. In summary, our study has revealed a key pathway underlying NE gene upregulation by ADT, as well as established novel …
Finally, genetic rescue experiments demonstrated that ADT induces NED through EZH2's repression of REST, which is enhanced by ADT-act …
CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation.
Wang Z, Hulsurkar M, Zhuo L, Xu J, Yang H, Naderinezhad S, Wang L, Zhang G, Ai N, Li L, Chang JT, Zhang S, Fazli L, Creighton CJ, Bai F, Ittmann MM, Gleave ME, Li W. Wang Z, et al. Neoplasia. 2021 Nov;23(11):1147-1165. doi: 10.1016/j.neo.2021.09.005. Epub 2021 Oct 24. Neoplasia. 2021. PMID: 34706306 Free PMC article.
We further elucidated that an 84aa fragment at C-terminus of CKB protein interacts with AKT's PH domain. Ectopic expression of the 84aa CKB fragment inhibits AKT activation, EMT and cell proliferation. Interestingly, molecular dynamics simulation on crystal structures of A …
We further elucidated that an 84aa fragment at C-terminus of CKB protein interacts with AKT's PH domain. Ectopic expression of the 84 …
New liposomal doxorubicin nanoformulation for osteosarcoma: Drug release kinetic study based on thermo and pH sensitivity.
Haghiralsadat F, Amoabediny G, Sheikhha MH, Zandieh-Doulabi B, Naderinezhad S, Helder MN, Forouzanfar T. Haghiralsadat F, et al. Chem Biol Drug Des. 2017 Sep;90(3):368-379. doi: 10.1111/cbdd.12953. Epub 2017 Apr 12. Chem Biol Drug Des. 2017. PMID: 28120466
The liposomal formulation was evaluated by determining mean size of vesicle, encapsulation efficiency, polydispersity index, zeta potentials, carrier's functionalization, and surface morphology. The vesicle size, encapsulation efficiency, polydispersity index, and zeta pot …
The liposomal formulation was evaluated by determining mean size of vesicle, encapsulation efficiency, polydispersity index, zeta potentials …