Microscale geometrical modulation of PIEZO1 mediated mechanosensing through cytoskeletal redistribution.
Wang HJ, Wang Y, Mirjavadi SS, Andersen T, Moldovan L, Vatankhah P, Russell B, Jin J, Zhou Z, Li Q, Cox CD, Su QP, Ju LA.
Wang HJ, et al.
Nat Commun. 2024 Jun 29;15(1):5521. doi: 10.1038/s41467-024-49833-6.
Nat Commun. 2024.
PMID: 38951553
Free PMC article.
We reveal that increased micropipette tip angles and physical constrictions lead to a significant reorganization of F-actin, accumulation at the aspirated cell neck, and subsequently amplify the tension stress at the dome of the cell to induce more PIEZO1's activity. Disru …
We reveal that increased micropipette tip angles and physical constrictions lead to a significant reorganization of F-actin, accumulation at …