Curtailing FGF19's mitogenicity by suppressing its receptor dimerization ability.
Niu J, Zhao J, Wu J, Qiao G, Gu J, Zhou C, Li Q, Ying L, Wang D, Lin H, Li X, Mohammadi M, Huang Z.
Niu J, et al.
Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29025-29034. doi: 10.1073/pnas.2010984117. Epub 2020 Nov 3.
Proc Natl Acad Sci U S A. 2020.
PMID: 33144503
Free PMC article.
Here, we show that nonmitogenic FGF19 variants that retain the full beneficial glucose-lowering and bile acid regulatory activities of WT FGF19 (FGF19(WT)) can be engineered by diminishing FGF19's ability to induce dimerization of its cognate FGF receptors (FGFR). As proof …
Here, we show that nonmitogenic FGF19 variants that retain the full beneficial glucose-lowering and bile acid regulatory activities of WT FG …