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119 results

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Page 1
Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response.
Zhang Y, Narayanan SP, Mannan R, Raskind G, Wang X, Vats P, Su F, Hosseini N, Cao X, Kumar-Sinha C, Ellison SJ, Giordano TJ, Morgan TM, Pitchiaya S, Alva A, Mehra R, Cieslik M, Dhanasekaran SM, Chinnaiyan AM. Zhang Y, et al. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2103240118. doi: 10.1073/pnas.2103240118. Proc Natl Acad Sci U S A. 2021. PMID: 34099557 Free PMC article.
Discovery of an LSD1 PROTAC degrader.
Hosseini A, Qiu X, Xiong Y, Chiang KHN, Catlett J, Kaltheuner I, Deng Z, Ghosh S, Shi Y, Jin J. Hosseini A, et al. Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2425812122. doi: 10.1073/pnas.2425812122. Epub 2025 May 14. Proc Natl Acad Sci U S A. 2025. PMID: 40366693 Free PMC article.
The global, regional, and national burden of cancer, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023.
GBD 2023 Cancer Collaborators. GBD 2023 Cancer Collaborators. Lancet. 2025 Oct 11;406(10512):1565-1586. doi: 10.1016/S0140-6736(25)01635-6. Epub 2025 Sep 24. Lancet. 2025. PMID: 41015051 Free PMC article.
FUNDING: Gates Foundation, St Jude Children's Research Hospital, and St Baldrick's Foundation....
FUNDING: Gates Foundation, St Jude Children's Research Hospital, and St Baldrick's Foundation....
Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
GBD 2023 Causes of Death Collaborators. GBD 2023 Causes of Death Collaborators. Lancet. 2025 Oct 18;406(10513):1811-1872. doi: 10.1016/S0140-6736(25)01917-8. Epub 2025 Oct 12. Lancet. 2025. PMID: 41092928 Free PMC article.
The expected mean age reflects the expected mean age at death for individuals within a population, based on global mortality rates and the population's age structure. Comparatively, the observed mean age represents the actual mean age at death, influenced by all factors un …
The expected mean age reflects the expected mean age at death for individuals within a population, based on global mortality rates and the p …
The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease.
Lonnemann N, Hosseini S, Marchetti C, Skouras DB, Stefanoni D, D'Alessandro A, Dinarello CA, Korte M. Lonnemann N, et al. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):32145-32154. doi: 10.1073/pnas.2009680117. Epub 2020 Nov 30. Proc Natl Acad Sci U S A. 2020. PMID: 33257576 Free PMC article.
Numerous studies demonstrate that neuroinflammation is a key player in the progression of Alzheimer's disease (AD). Interleukin (IL)-1beta is a main inducer of inflammation and therefore a prime target for therapeutic options. ...
Numerous studies demonstrate that neuroinflammation is a key player in the progression of Alzheimer's disease (AD). Interleukin (IL)- …
Novel effects of Rosa damascena extract on memory and neurogenesis in a rat model of Alzheimer's disease.
Esfandiary E, Karimipour M, Mardani M, Alaei H, Ghannadian M, Kazemi M, Mohammadnejad D, Hosseini N, Esmaeili A. Esfandiary E, et al. J Neurosci Res. 2014 Apr;92(4):517-30. doi: 10.1002/jnr.23319. Epub 2014 Jan 2. J Neurosci Res. 2014. PMID: 24395280
The number of older people who are suffering from memory impairment is increasing among populations throughout the world. Alzheimer's disease (AD) affects about 5% of people over 65 years old. The hippocampus, a brain area critical for learning and memory, is especially vu …
The number of older people who are suffering from memory impairment is increasing among populations throughout the world. Alzheimer's …
Global biogeography of human infectious diseases.
Murray KA, Preston N, Allen T, Zambrana-Torrelio C, Hosseini PR, Daszak P. Murray KA, et al. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12746-51. doi: 10.1073/pnas.1507442112. Epub 2015 Sep 28. Proc Natl Acad Sci U S A. 2015. PMID: 26417098 Free PMC article.
Intragenic enhancers act as alternative promoters.
Kowalczyk MS, Hughes JR, Garrick D, Lynch MD, Sharpe JA, Sloane-Stanley JA, McGowan SJ, De Gobbi M, Hosseini M, Vernimmen D, Brown JM, Gray NE, Collavin L, Gibbons RJ, Flint J, Taylor S, Buckle VJ, Milne TA, Wood WG, Higgs DR. Kowalczyk MS, et al. Mol Cell. 2012 Feb 24;45(4):447-58. doi: 10.1016/j.molcel.2011.12.021. Epub 2012 Jan 19. Mol Cell. 2012. PMID: 22264824 Free article.
Here we show that activated, intragenic enhancers frequently act as alternative tissue-specific promoters producing a class of abundant, spliced, multiexonic poly(A)(+) RNAs (meRNAs) which reflect the host gene's structure. meRNAs make a substantial and unanticipated contr …
Here we show that activated, intragenic enhancers frequently act as alternative tissue-specific promoters producing a class of abundant, spl …
119 results