Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1908 1
1969 1
1980 1
1982 1
1983 3
1984 2
1985 3
1986 2
1987 3
1988 7
1989 2
1990 2
1991 8
1992 6
1993 2
1994 6
1995 10
1996 13
1997 32
1998 34
1999 34
2000 26
2001 32
2002 35
2003 37
2004 33
2005 29
2006 29
2007 32
2008 36
2009 20
2010 41
2011 29
2012 42
2013 51
2014 52
2015 39
2016 27
2017 23
2018 37
2019 33
2020 40
2021 52
2022 46
2023 68
2024 59
2025 29

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

1,053 results

Results by year

Filters applied: . Clear all
Page 1
Role of platelets and platelet receptors in cancer metastasis.
Schlesinger M. Schlesinger M. J Hematol Oncol. 2018 Oct 11;11(1):125. doi: 10.1186/s13045-018-0669-2. J Hematol Oncol. 2018. PMID: 30305116 Free PMC article. Review.
This review provides a synopsis on the current literature on platelet-mediated effects in cancer metastasis and particularly focuses on platelet adhesion receptors and their role in metastasis. Immunoreceptor tyrosine-based activation motif (ITA …
This review provides a synopsis on the current literature on platelet-mediated effects in cancer metastasis and particularly focuses on plat …
CAR-modified memory-like NK cells exhibit potent responses to NK-resistant lymphomas.
Gang M, Marin ND, Wong P, Neal CC, Marsala L, Foster M, Schappe T, Meng W, Tran J, Schaettler M, Davila M, Gao F, Cashen AF, Bartlett NL, Mehta-Shah N, Kahl BS, Kim MY, Cooper ML, DiPersio JF, Berrien-Elliott MM, Fehniger TA. Gang M, et al. Blood. 2020 Nov 12;136(20):2308-2318. doi: 10.1182/blood.2020006619. Blood. 2020. PMID: 32614951 Free PMC article.
Cytokine-induced memory-like (ML) NK cells differentiate after activation with interleukin-12 (IL-12), IL-15, and IL-18, exhibit potent antitumor responses, and safely induce complete remissions in patients with leukemia. ...The 19-CAR and ML responses were synergistic and …
Cytokine-induced memory-like (ML) NK cells differentiate after activation with interleukin-12 (IL-12), IL-15, and IL-18, exhibit pote …
Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency.
Feucht J, Sun J, Eyquem J, Ho YJ, Zhao Z, Leibold J, Dobrin A, Cabriolu A, Hamieh M, Sadelain M. Feucht J, et al. Nat Med. 2019 Jan;25(1):82-88. doi: 10.1038/s41591-018-0290-5. Epub 2018 Dec 17. Nat Med. 2019. PMID: 30559421 Free PMC article.
Thus, we hypothesized that calibrating the activation potential of CD28-based CARs would differentially reprogram T cell function and differentiation. Here, we show that CARs encoding a single immunoreceptor tyrosine-based activation motif
Thus, we hypothesized that calibrating the activation potential of CD28-based CARs would differentially reprogram T cell function and …
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.
Nishimura H, Nose M, Hiai H, Minato N, Honjo T. Nishimura H, et al. Immunity. 1999 Aug;11(2):141-51. doi: 10.1016/s1074-7613(00)80089-8. Immunity. 1999. PMID: 10485649 Free article.
PD-1, a 55 kDa transmembrane protein containing an immunoreceptor tyrosine-based inhibitory motif, is induced in lymphocytes and monocytic cells following activation. ...
PD-1, a 55 kDa transmembrane protein containing an immunoreceptor tyrosine-based inhibitory motif, is induced in …
Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice.
Zhao P, Xu Y, Fan X, Li L, Li X, Arase H, Tong Q, Zhang N, An Z. Zhao P, et al. MAbs. 2022 Jan-Dec;14(1):2107971. doi: 10.1080/19420862.2022.2107971. MAbs. 2022. PMID: 35921534 Free PMC article.
Triggering receptor expressed on myeloid cells 2 (TREM2) plays a crucial role in regulating microglial functions and removal of amyloid plaques in Alzheimer's disease (AD). However, therapeutics based on this knowledge have not been developed due to the low antibody brain …
Triggering receptor expressed on myeloid cells 2 (TREM2) plays a crucial role in regulating microglial functions and removal of amyloid plaq …
Platelet ITAM signaling.
Bergmeier W, Stefanini L. Bergmeier W, et al. Curr Opin Hematol. 2013 Sep;20(5):445-50. doi: 10.1097/MOH.0b013e3283642267. Curr Opin Hematol. 2013. PMID: 23921514 Review.
PURPOSE OF REVIEW: G protein-coupled receptors (GPCRs) like PAR1/4 and P2Y12 have long been known for their critical role in hemostasis. In contrast, deficiency in the immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors glyco …
PURPOSE OF REVIEW: G protein-coupled receptors (GPCRs) like PAR1/4 and P2Y12 have long been known for their critical role in hemostasis. In …
Evaluation of CD33 as a genetic risk factor for Alzheimer's disease.
Estus S, Shaw BC, Devanney N, Katsumata Y, Press EE, Fardo DW. Estus S, et al. Acta Neuropathol. 2019 Aug;138(2):187-199. doi: 10.1007/s00401-019-02000-4. Epub 2019 Apr 4. Acta Neuropathol. 2019. PMID: 30949760 Free PMC article. Review.
Subsequent studies found that CD33 is expressed in microglia in the brain and then investigated the molecular mechanism underlying the CD33 genetic association with Alzheimer's disease. The allele that protects from Alzheimer's disease acts predominately to increase …
Subsequent studies found that CD33 is expressed in microglia in the brain and then investigated the molecular mechanism underlying the CD33 …
The TREM-1/DAP12 pathway.
Tessarz AS, Cerwenka A. Tessarz AS, et al. Immunol Lett. 2008 Mar 15;116(2):111-6. doi: 10.1016/j.imlet.2007.11.021. Epub 2007 Dec 26. Immunol Lett. 2008. PMID: 18192027 Review.
DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter, which couples to multiple receptors expressed on natural killer (NK) cells, monocytes, and neutrophils. ...In myeloid ce …
DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITA …
TREM2-Dependent Effects on Microglia in Alzheimer's Disease.
Zhou Y, Ulland TK, Colonna M. Zhou Y, et al. Front Aging Neurosci. 2018 Jul 9;10:202. doi: 10.3389/fnagi.2018.00202. eCollection 2018. Front Aging Neurosci. 2018. PMID: 30038567 Free PMC article. Review.
Alzheimer's disease (AD) is a late-onset dementia characterized by the deposition of amyloid plaques and formation of neurofibrillary tangles (NFTs) which lead to neuronal loss and cognitive deficits. ...The transmembrane domain of TREM2 signals through DAP12, an adaptor p …
Alzheimer's disease (AD) is a late-onset dementia characterized by the deposition of amyloid plaques and formation of neurofibrillary …
Siglec functions of microglia.
Linnartz-Gerlach B, Kopatz J, Neumann H. Linnartz-Gerlach B, et al. Glycobiology. 2014 Sep;24(9):794-9. doi: 10.1093/glycob/cwu044. Epub 2014 May 15. Glycobiology. 2014. PMID: 24833613 Review.
Therefore, microglia need recognition receptors that lead to either the activation or the inhibition of the immune response pathways. Most Siglecs contain an immunoreceptor tyrosine based inhibition motif and its signaling leads to the terminati …
Therefore, microglia need recognition receptors that lead to either the activation or the inhibition of the immune response pathways. …
1,053 results