The oncogenic potential of NANOG: An important cancer induction mediator.
Najafzadeh B, Asadzadeh Z, Motafakker Azad R, Mokhtarzadeh A, Baghbanzadeh A, Alemohammad H, Abdoli Shadbad M, Vasefifar P, Najafi S, Baradaran B.
Najafzadeh B, et al.
J Cell Physiol. 2021 Apr;236(4):2443-2458. doi: 10.1002/jcp.30063. Epub 2020 Sep 22.
J Cell Physiol. 2021.
PMID: 32960465
Review.
CSCs overexpress embryonic transcription factor NANOG, which is downregulated in differentiated tissues. This transcription factor confers CSC's stemness, unlimited self-renewal, metastasis, invasiveness, angiogenesis, and drug-resistance with the assistance of WNT, OCT4, …
CSCs overexpress embryonic transcription factor NANOG, which is downregulated in differentiated tissues. This transcription factor confers C …