Mesna (2-mercaptoethane sodium sulfonate) functions as a regulator of myeloperoxidase.
Jeelani R, Jahanbakhsh S, Kohan-Ghadr HR, Thakur M, Khan S, Aldhaheri SR, Yang Z, Andreana P, Morris R, Abu-Soud HM.
Jeelani R, et al.
Free Radic Biol Med. 2017 Sep;110:54-62. doi: 10.1016/j.freeradbiomed.2017.05.019. Epub 2017 May 25.
Free Radic Biol Med. 2017.
PMID: 28552694
Free PMC article.
Mesna competes with Cl(-), inhibiting MPO's chlorinating activity with an IC(50) of 5M, and switches the reaction from a 2e(-) to a 1e(-) pathway allowing the enzyme to function only with catalase-like activity. ...
Mesna competes with Cl(-), inhibiting MPO's chlorinating activity with an IC(50) of 5M, and switches the reaction from a 2e(-) to a 1 …