FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.
Feng Y, Li C, Stewart JA, Barbulescu P, Seija Desivo N, Álvarez-Quilón A, Pezo RC, Perera MLW, Chan K, Tong AHY, Mohamad-Ramshan R, Berru M, Nakib D, Li G, Kardar GA, Carlyle JR, Moffat J, Durocher D, Di Noia JM, Bhagwat AS, Martin A.
Feng Y, et al.
Nature. 2021 Dec;600(7888):324-328. doi: 10.1038/s41586-021-04144-4. Epub 2021 Nov 24.
Nature. 2021.
PMID: 34819670
Free PMC article.
FAM72A therefore causes U.G mispairs to persist into S phase, leading to error-prone processing by mismatch repair. By disabling the DNA repair pathways that normally efficiently remove deoxyuracils from DNA, FAM72A enables AID to exert its full effects on antibody maturat …
FAM72A therefore causes U.G mispairs to persist into S phase, leading to error-prone processing by mismatch repair. By disabling the …