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Page 1
Health Consequences of Thymus Removal in Adults.
Kooshesh KA, Foy BH, Sykes DB, Gustafsson K, Scadden DT. Kooshesh KA, et al. N Engl J Med. 2023 Aug 3;389(5):406-417. doi: 10.1056/NEJMoa2302892. N Engl J Med. 2023. PMID: 37530823 Free PMC article.
In an analysis involving all patients with more than 5 years of follow-up (with or without a matched control), all-cause mortality was higher in the thymectomy group than in the general U.S. population (9.0% vs. 5.2%), as was mortality due to cancer (2.3% vs. 1.5%). In the …
In an analysis involving all patients with more than 5 years of follow-up (with or without a matched control), all-cause mortality was highe …
Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity.
Gustafsson K, Isaev S, Mirsanaye K, Hofmann J, Kooshesh KA, Baryawno N, Kiem A, Severe N, Zhao T, Scadden EW, Spencer JA, Burns C, Akilan K, Barkas N, Gessessew H, Kokkaliaris KD, Lin CP, Kharchenko PV, Scadden DT. Gustafsson K, et al. Nat Biotechnol. 2025 Oct 30:10.1038/s41587-025-02864-w. doi: 10.1038/s41587-025-02864-w. Online ahead of print. Nat Biotechnol. 2025. PMID: 41168496 Free PMC article.
Effects of kisspeptin on the maturation of human ovarian primordial follicles in vitro.
Rezaei-Tazangi F, Kooshesh L, Tayyebiazar A, Taghizabet N, Tavakoli A, Hassanpour A, Aliakbari F, Kharazinejad E, Sharifi AM. Rezaei-Tazangi F, et al. Zygote. 2024 Feb;32(1):66-70. doi: 10.1017/S0967199423000527. Epub 2023 Dec 15. Zygote. 2024. PMID: 38099429
Data were analyzed using one-way analysis of variance (ANOVA) and Tukey's test; means were considered significantly different at a P-value < 0.05. During treatment with the kisspeptin group, maturity genes are expressed. ...
Data were analyzed using one-way analysis of variance (ANOVA) and Tukey's test; means were considered significantly different at a P- …
Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation.
Cieri N, Hookeri N, Stromhaug K, Li L, Keating J, Díaz-Fernández P, Gómez-García de Soria V, Stevens J, Kfuri-Rubens R, Shao Y, Kooshesh KA, Powell K, Ji H, Hernandez GM, Abelin J, Klaeger S, Forman C, Clauser KR, Sarkizova S, Braun DA, Penter L, Kim HT, Lane WJ, Oliveira G, Kean LS, Li S, Livak KJ, Carr SA, Keskin DB, Muñoz-Calleja C, Ho VT, Ritz J, Soiffer RJ, Neuberg D, Stewart C, Getz G, Wu CJ. Cieri N, et al. Nat Biotechnol. 2025 Jun;43(6):971-982. doi: 10.1038/s41587-024-02348-3. Epub 2024 Aug 21. Nat Biotechnol. 2025. PMID: 39169264 Free PMC article.
High-throughput mapping of regulatory DNA.
Rajagopal N, Srinivasan S, Kooshesh K, Guo Y, Edwards MD, Banerjee B, Syed T, Emons BJ, Gifford DK, Sherwood RI. Rajagopal N, et al. Nat Biotechnol. 2016 Feb;34(2):167-74. doi: 10.1038/nbt.3468. Epub 2016 Jan 25. Nat Biotechnol. 2016. PMID: 26807528 Free PMC article.
Comparing the Radiologic and Functional Outcome of Radial Shortening Versus Capitate Shortening in Management of Kienbock's Disease.
Mazhar FN, Motaghi P, Kooshesh MR, Mahmoudinasab O. Mazhar FN, et al. Hand (N Y). 2023 Oct;18(7):1120-1128. doi: 10.1177/15589447221081564. Epub 2022 Mar 23. Hand (N Y). 2023. PMID: 35321588 Free PMC article. Clinical Trial.
BACKGROUND: Kienbock's disease is the avascular necrosis of the lunate bone. There is no consensus on the treatment strategy to avoid joint deterioration. ...METHODS: Patients with a confirmed diagnosis of Kienbock's disease who met the inclusion criteria were rando …
BACKGROUND: Kienbock's disease is the avascular necrosis of the lunate bone. There is no consensus on the treatment strategy to avoid …
An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery.
Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Söylemez O, Sutti S, Kooshesh K, Qiu H, Fay CJ, Perroni V, Valerius J, Hanna M, Frank A, Ouahed J, Snapper SB, Pantazi A, Chopra SS, Leshchiner I, Stitziel NO, Feldweg A, Mannstadt M, Loscalzo J, Sweetser DA, Liao E, Stoler JM, Nowak CB, Sanchez-Lara PA, Klein OD, Perry H, Patsopoulos NA, Raychaudhuri S, Goessling W, Green RC, Seidman CE, MacRae CA, Sunyaev SR, Maas RL, Vuzman D; Undiagnosed Diseases Network, Brigham and Women’s Hospital FaceBase Project, Brigham Genomic Medicine (BGM). Haghighi A, et al. NPJ Genom Med. 2018 Aug 13;3:21. doi: 10.1038/s41525-018-0060-9. eCollection 2018. NPJ Genom Med. 2018. PMID: 30131872 Free PMC article. Review.
An accessible, efficient, and accurate natural language processing method for extracting diagnostic data from pathology reports.
Lam H, Nguyen F, Wang X, Stock A, Lenskaya V, Kooshesh M, Li P, Qazi M, Wang S, Dehghan M, Qian X, Si Q, Polydorides AD. Lam H, et al. J Pathol Inform. 2022 Nov 8;13:100154. doi: 10.1016/j.jpi.2022.100154. eCollection 2022. J Pathol Inform. 2022. PMID: 36605108 Free PMC article.
Accuracy and efficiency were compared to a manual data extraction method with concordance measured by Cohen's kappa coefficient and corresponding P values. RESULTS: The automated method was highly concordant (90%-100%, P<.001) with excellent inter-observer reliability ( …
Accuracy and efficiency were compared to a manual data extraction method with concordance measured by Cohen's kappa coefficient and c …
24 results