Sacco MD[au] - Search Results

Year	Number of Results
2019	2
2020	7
2021	4
2022	5
2023	1

1

Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors.

Kitamura N, Sacco MD, Ma C, Hu Y, Townsend JA, Meng X, Zhang F, Zhang X, Ba M, Szeto T, Kukuljac A, Marty MT, Schultz D, Cherry S, Xiang Y, Chen Y, Wang J. Kitamura N, et al. Among authors: sacco md. J Med Chem. 2022 Feb 24;65(4):2848-2865. doi: 10.1021/acs.jmedchem.1c00509. Epub 2021 Apr 23. J Med Chem. 2022. PMID: 33891389 Free PMC article.

2

Structure-Based Ligand Design Targeting Pseudomonas aeruginosa LpxA in Lipid A Biosynthesis.

Sacco MD, Defrees K, Zhang X, Lawless W, Nwanochie E, Balsizer A, Darch SE, Renslo AR, Chen Y. Sacco MD, et al. ACS Infect Dis. 2022 Jul 8;8(7):1231-1240. doi: 10.1021/acsinfecdis.1c00650. Epub 2022 Jun 2. ACS Infect Dis. 2022. PMID: 35653508

3

A unique class of Zn²⁺-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile.

Sacco MD, Wang S, Adapa SR, Zhang X, Lewandowski EM, Gongora MV, Keramisanou D, Atlas ZD, Townsend JA, Gatdula JR, Morgan RT, Hammond LR, Marty MT, Wang J, Eswara PJ, Gelis I, Jiang RHY, Sun X, Chen Y. Sacco MD, et al. Nat Commun. 2022 Jul 28;13(1):4370. doi: 10.1038/s41467-022-32086-6. Nat Commun. 2022. PMID: 35902581 Free PMC article.

4

GpsB Coordinates Cell Division and Cell Surface Decoration by Wall Teichoic Acids in Staphylococcus aureus.

Hammond LR, Sacco MD, Khan SJ, Spanoudis C, Hough-Neidig A, Chen Y, Eswara PJ. Hammond LR, et al. Among authors: sacco md. Microbiol Spectr. 2022 Jun 29;10(3):e0141322. doi: 10.1128/spectrum.01413-22. Epub 2022 Jun 1. Microbiol Spectr. 2022. PMID: 35647874 Free PMC article.

5

The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition.

Sacco MD, Hu Y, Gongora MV, Meilleur F, Kemp MT, Zhang X, Wang J, Chen Y. Sacco MD, et al. Cell Res. 2022 May;32(5):498-500. doi: 10.1038/s41422-022-00640-y. Epub 2022 Mar 15. Cell Res. 2022. PMID: 35292745 Free PMC article. No abstract available.

6

Interdependent YpsA- and YfhS-Mediated Cell Division and Cell Size Phenotypes in Bacillus subtilis.

Brzozowski RS, Tomlinson BR, Sacco MD, Chen JJ, Ali AN, Chen Y, Shaw LN, Eswara PJ. Brzozowski RS, et al. Among authors: sacco md. mSphere. 2020 Jul 22;5(4):e00655-20. doi: 10.1128/mSphere.00655-20. mSphere. 2020. PMID: 32699122 Free PMC article.

7

Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity.

Ma C, Xia Z, Sacco MD, Hu Y, Townsend JA, Meng X, Choza J, Tan H, Jang J, Gongora MV, Zhang X, Zhang F, Xiang Y, Marty MT, Chen Y, Wang J. Ma C, et al. Among authors: sacco md. J Am Chem Soc. 2021 Dec 15;143(49):20697-20709. doi: 10.1021/jacs.1c08060. Epub 2021 Dec 3. J Am Chem Soc. 2021. PMID: 34860011 Free PMC article.

8

Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β-Lactamases.

Durand-Réville TF, Comita-Prevoir J, Zhang J, Wu X, May-Dracka TL, Romero JAC, Wu F, Chen A, Shapiro AB, Carter NM, McLeod SM, Giacobbe RA, Verheijen JC, Lahiri SD, Sacco MD, Chen Y, O'Donnell JP, Miller AA, Mueller JP, Tommasi RA. Durand-Réville TF, et al. Among authors: sacco md. J Med Chem. 2020 Nov 12;63(21):12511-12525. doi: 10.1021/acs.jmedchem.0c00579. Epub 2020 Jul 24. J Med Chem. 2020. PMID: 32658473 Free PMC article.

9

Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography.

Kroeck KG, Sacco MD, Smith EW, Zhang X, Shoun D, Akhtar A, Darch SE, Cohen F, Andrews LD, Knox JE, Chen Y. Kroeck KG, et al. Among authors: sacco md. Sci Rep. 2019 Oct 29;9(1):15450. doi: 10.1038/s41598-019-51844-z. Sci Rep. 2019. PMID: 31664082 Free PMC article.

10

Development of the Safe and Broad-Spectrum Aldehyde and Ketoamide Mpro inhibitors Derived from the Constrained α, γ-AA Peptide Scaffold.

Wang L, Ma C, Sacco MD, Xue S, Mahmoud M, Calcul L, Chen Y, Wang J, Cai J. Wang L, et al. Among authors: sacco md. Chemistry. 2023 Jun 22;29(35):e202300476. doi: 10.1002/chem.202300476. Epub 2023 May 5. Chemistry. 2023. PMID: 36920943

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