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1994 1
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124 results

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Page 1
SAR1A regulates the RhoA/YAP and autophagy signaling pathways to influence osteosarcoma invasion and metastasis.
Zhan F, Deng Q, Chen Z, Xie C, Xiang S, Qiu S, Tian L, Wu C, Ou Y, Chen J, Xu L. Zhan F, et al. Cancer Sci. 2022 Dec;113(12):4104-4119. doi: 10.1111/cas.15551. Epub 2022 Sep 15. Cancer Sci. 2022. PMID: 36047971 Free PMC article.
In addition, the upregulation of SAR1A and RHOA in osteosarcoma was highly positively correlated. Immunohistochemical analyses additionally revealed that SAR1A levels were increased in osteosarcoma pulmonary metastases. ...Western blotting and immunofluorescent stai …
In addition, the upregulation of SAR1A and RHOA in osteosarcoma was highly positively correlated. Immunohistochemical analyses additi …
SAR1B senses leucine levels to regulate mTORC1 signalling.
Chen J, Ou Y, Luo R, Wang J, Wang D, Guan J, Li Y, Xia P, Chen PR, Liu Y. Chen J, et al. Nature. 2021 Aug;596(7871):281-284. doi: 10.1038/s41586-021-03768-w. Epub 2021 Jul 21. Nature. 2021. PMID: 34290409
The silencing of SAR1B and its paralogue SAR1A promotes mTORC1-dependent growth of lung tumours in mice. Our results reveal that SAR1B is a conserved leucine sensor that has a potential role in the development of lung cancer....
The silencing of SAR1B and its paralogue SAR1A promotes mTORC1-dependent growth of lung tumours in mice. Our results reveal that SAR1 …
TGF-beta1 upregulates Sar1a expression and induces procollagen-I secretion in hypertrophic scarring fibroblasts.
Ahn KJ, Kim JS. Ahn KJ, et al. Open Med (Wars). 2022 Sep 17;17(1):1473-1482. doi: 10.1515/med-2022-0543. eCollection 2022. Open Med (Wars). 2022. PMID: 36188194 Free PMC article.
We conducted this study to explore the cellular signaling mechanisms for expression of Sar1a, a coat protein complex II-associated small GTPase, in HTS fibroblasts (HTSF). We found that Sar1a was upregulated in HTSF as compared to that in normal fibroblasts. Further …
We conducted this study to explore the cellular signaling mechanisms for expression of Sar1a, a coat protein complex II-associated sm …
Sar1A overexpression in Chinese hamster ovary cells and its effects on antibody productivity and secretion.
Tsunoda Y, Yamano-Adachi N, Koga Y, Omasa T. Tsunoda Y, et al. J Biosci Bioeng. 2024 Aug;138(2):171-180. doi: 10.1016/j.jbiosc.2024.05.003. Epub 2024 May 28. J Biosci Bioeng. 2024. PMID: 38806389
The constructed Sar1A-overexpressing CHO cell lines were batch-cultured, in which they showed an increased specific antibody production rate. ...Sar1A overexpression enhanced the antibody productivity of CHO cells by modifying their secretion process. ...
The constructed Sar1A-overexpressing CHO cell lines were batch-cultured, in which they showed an increased specific antibody producti …
Circ-SAR1A Promotes Renal Cell Carcinoma Progression Through miR-382/YBX1 Axis.
Zhao X, Zhao Z, Xu W, Liu H, Chang J, Xu W, Li S, Cao S, Hou J. Zhao X, et al. Cancer Manag Res. 2020 Aug 18;12:7353-7361. doi: 10.2147/CMAR.S245918. eCollection 2020. Cancer Manag Res. 2020. PMID: 32884349 Free PMC article.
We explored the effect and function of circ-SAR1A in renal cell carcinoma (RCC). METHODS: circ-SAR1A expression in RCC tissues and cell lines was explored by qRT-PCR. ...RESULTS: Our data reveal that circ-SAR1A is significantly high in RCC tissues and cell li …
We explored the effect and function of circ-SAR1A in renal cell carcinoma (RCC). METHODS: circ-SAR1A expression in RCC tissues …
SAR1A Induces Cell Growth and Epithelial-Mesenchymal Transition Through the PI3K/AKT/mTOR Pathway in Head and Neck Squamous Cell Carcinoma: An In Vitro and In Vivo Study.
Fang S, Wang J, Liu T, Jiang Y, Hua Q. Fang S, et al. Biomedicines. 2024 Oct 28;12(11):2477. doi: 10.3390/biomedicines12112477. Biomedicines. 2024. PMID: 39595043 Free PMC article.
In addition, the diminished capacities of proliferation, migration, and invasion observed in SAR1A knockdown cells were reversed upon the overexpression of SAR1A. Furthermore, RNA-seq and KEGG enrichment analysis demonstrated a significant alteration in the PAM path …
In addition, the diminished capacities of proliferation, migration, and invasion observed in SAR1A knockdown cells were reversed upon …
Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.
Tang VT, Xiang J, Chen Z, McCormick J, Abbineni PS, Chen XW, Hoenerhoff M, Emmer BT, Khoriaty R, Lin JD, Ginsburg D. Tang VT, et al. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2322164121. doi: 10.1073/pnas.2322164121. Epub 2024 Apr 30. Proc Natl Acad Sci U S A. 2024. PMID: 38687799 Free PMC article.
In contrast, we demonstrate that deletion of Sar1b restricted to hepatocytes is compatible with survival, though resulting in hypocholesterolemia that can be rescued by adenovirus-mediated overexpression of either SAR1A or SAR1B. To further examine the in vivo function of …
In contrast, we demonstrate that deletion of Sar1b restricted to hepatocytes is compatible with survival, though resulting in hypocholestero …
Circ_SAR1A regulates the malignant behavior of lung cancer cells via the miR-21-5p/TXNIP axis.
Zhao Y, Wan Y, He T. Zhao Y, et al. J Clin Lab Anal. 2022 May;36(5):e24366. doi: 10.1002/jcla.24366. Epub 2022 Mar 25. J Clin Lab Anal. 2022. PMID: 35334496 Free PMC article.
RNase R digestion and nuclear/cytoplasm fractionation experiments were utilized to determine the stability and localization of circ_SAR1A in lung cancer cells. The binding between miR-21-5p and circ_SAR1A or TXNIP was confirmed by luciferase reporter, RNA pull-down, …
RNase R digestion and nuclear/cytoplasm fractionation experiments were utilized to determine the stability and localization of circ_SAR1A …
Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.
Tang VT, Xiang J, Chen Z, McCormick J, Abbineni PS, Chen XW, Hoenerhoff M, Emmer BT, Khoriaty R, Lin JD, Ginsburg D. Tang VT, et al. bioRxiv [Preprint]. 2024 Feb 29:2024.02.27.582310. doi: 10.1101/2024.02.27.582310. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2322164121. doi: 10.1073/pnas.2322164121. PMID: 38463989 Free PMC article. Updated. Preprint.
In contrast, we demonstrate that deletion of Sar1b restricted to hepatocytes is compatible with survival, though resulting in hypocholesterolemia that can be rescued by adenovirus-mediated overexpression of either SAR1A or SAR1B. To further examine the in vivo function of …
In contrast, we demonstrate that deletion of Sar1b restricted to hepatocytes is compatible with survival, though resulting in hypocholestero …
124 results