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A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability.

Sirois I, Aguilar-Mahecha A, Lafleur J, Fowler E, Vu V, Scriver M, Buchanan M, Chabot C, Ramanathan A, Balachandran B, Légaré S, Przybytkowski E, Lan C, Krzemien U, Cavallone L, Aleynikova O, Ferrario C, Guilbert MC, Benlimame N, Saad A, Alaoui-Jamali M, Saragovi HU, Josephy S, O'Flanagan C, Hursting SD, Richard VR, Zahedi RP, Borchers CH, Bareke E, Nabavi S, Tonellato P, Roy JA, Robidoux A, Marcus EA, Mihalcioiu C, Majewski J, Basik M. Sirois I, et al. Among authors: saragovi hu. Mol Cancer Res. 2019 Dec;17(12):2492-2507. doi: 10.1158/1541-7786.MCR-19-0264. Epub 2019 Sep 19. Mol Cancer Res. 2019. PMID: 31537618 Free article.

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Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy.

Bartish M, Del Rincón SV, Rudd CE, Saragovi HU. Bartish M, et al. Among authors: saragovi hu. Front Immunol. 2020 Sep 29;11:564499. doi: 10.3389/fimmu.2020.564499. eCollection 2020. Front Immunol. 2020. PMID: 33133075 Free PMC article. Review.

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Neuroprotection: Pro-survival and Anti-neurotoxic Mechanisms as Therapeutic Strategies in Neurodegeneration.

Saragovi HU, Galan A, Levin LA. Saragovi HU, et al. Front Cell Neurosci. 2019 Jun 6;13:231. doi: 10.3389/fncel.2019.00231. eCollection 2019. Front Cell Neurosci. 2019. PMID: 31244606 Free PMC article. Review.

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Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands.

Brahimi F, Galan A, Jmaeff S, Barcelona PF, De Jay N, Dejgaard K, Young JC, Kleinman CL, Thomas DY, Saragovi HU. Brahimi F, et al. Among authors: saragovi hu. iScience. 2020 Aug 10;23(9):101447. doi: 10.1016/j.isci.2020.101447. Online ahead of print. iScience. 2020. PMID: 32829283 Free PMC article.

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Neurotrophin receptor agonists and antagonists as therapeutic agents: An evolving paradigm.

Josephy-Hernandez S, Jmaeff S, Pirvulescu I, Aboulkassim T, Saragovi HU. Josephy-Hernandez S, et al. Among authors: saragovi hu. Neurobiol Dis. 2017 Jan;97(Pt B):139-155. doi: 10.1016/j.nbd.2016.08.004. Epub 2016 Aug 18. Neurobiol Dis. 2017. PMID: 27546056 Review.

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Functional mimetics of neurotrophins and their receptors.

Peleshok J, Saragovi HU. Peleshok J, et al. Among authors: saragovi hu. Biochem Soc Trans. 2006 Aug;34(Pt 4):612-7. doi: 10.1042/BST0340612. Biochem Soc Trans. 2006. PMID: 16856874 Review.

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Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation.

Josephy-Hernandez S, Pirvulescu I, Maira M, Aboulkassim T, Wong TP, McKinney RA, Saragovi HU. Josephy-Hernandez S, et al. Among authors: saragovi hu. PLoS One. 2019 Jun 24;14(6):e0218036. doi: 10.1371/journal.pone.0218036. eCollection 2019. PLoS One. 2019. PMID: 31233568 Free PMC article.

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Novel approaches for targeted cancer therapy.

Guillemard V, Saragovi HU. Guillemard V, et al. Among authors: saragovi hu. Curr Cancer Drug Targets. 2004 Jun;4(4):313-26. doi: 10.2174/1568009043332989. Curr Cancer Drug Targets. 2004. PMID: 15180497 Review.

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A neurotrophic rationale for the therapy of neurodegenerative disorders.

Saragovi HU, Hamel E, Di Polo A. Saragovi HU, et al. Curr Alzheimer Res. 2009 Oct;6(5):419-23. doi: 10.2174/156720509789207912. Curr Alzheimer Res. 2009. PMID: 19874265 Review.

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Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease.

Xhima K, Markham-Coultes K, Nedev H, Heinen S, Saragovi HU, Hynynen K, Aubert I. Xhima K, et al. Among authors: saragovi hu. Sci Adv. 2020 Jan 22;6(4):eaax6646. doi: 10.1126/sciadv.aax6646. eCollection 2020 Jan. Sci Adv. 2020. PMID: 32010781 Free PMC article.

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