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162 results

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Page 1
SASH1 Mutations and Hereditary Disorders of Pigmentation: Review of Literature.
Bishnoi A, Arunima A, Vinay K, Kumaran MS, Parsad D. Bishnoi A, et al. Pigment Cell Melanoma Res. 2025 Jul;38(4):e70032. doi: 10.1111/pcmr.70032. Pigment Cell Melanoma Res. 2025. PMID: 40511878 Review.
Although mutations in ABCB6 account for many DUH cases, recently, the SAM and SH3 domain-containing 1 (SASH1) gene has emerged as a key player in DUH. Additionally, SASH1 mutations have been associated with the pure-lentiginous phenotype of familial pigmentation. .. …
Although mutations in ABCB6 account for many DUH cases, recently, the SAM and SH3 domain-containing 1 (SASH1) gene has emerged as a k …
A multi-omics pipeline integrating machine learning and spatial-cellular analysis identifies SASH1 as a prognostic biomarker and therapeutic target in head and neck squamous cell carcinoma.
Dai Z, Shan X, Kang Y, Chen Y, Feng Q, Cai Z, Xie S. Dai Z, et al. Int J Surg. 2025 Dec 1;111(12):9178-9195. doi: 10.1097/JS9.0000000000003647. Epub 2025 Oct 16. Int J Surg. 2025. PMID: 41099090 Free PMC article.

Western blot confirmed the significant downregulation of SASH1 protein in HNSCC cells compared to controls. Importantly, low SASH1 expression was significantly associated with poorer overall survival in the TCGA cohort ( P < 0.05), a prognostic value not observed

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Western blot confirmed the significant downregulation of SASH1 protein in HNSCC cells compared to controls. Importantly, low SASH1 …
SASH1 suppresses triple-negative breast cancer cell invasion through YAP-ARHGAP42-actin axis.
Jiang K, Liu P, Xu H, Liang D, Fang K, Du S, Cheng W, Ye L, Liu T, Zhang X, Gong P, Shao S, Wang Y, Meng S. Jiang K, et al. Oncogene. 2020 Jul;39(27):5015-5030. doi: 10.1038/s41388-020-1356-7. Epub 2020 Jun 10. Oncogene. 2020. PMID: 32523092
Furthermore, SASH1-induced YAP signaling was LATS1-dependent, which in reverse enhanced phosphorylation of SASH1. The SASH1 S407A mutant (phosphorylation deficient) failed to rescue the altered YAP signaling by SASH1 knockdown. ...
Furthermore, SASH1-induced YAP signaling was LATS1-dependent, which in reverse enhanced phosphorylation of SASH1. The SASH1 …
SASH1: A Novel Eph Receptor Partner and Insights into SAM-SAM Interactions.
Ding Y, Chen Q, Shan H, Liu J, Lv C, Wang Y, Yuan L, Chen Y, Wang Z, Yin Y, Xiao K, Li J, Liu W. Ding Y, et al. J Mol Biol. 2023 Oct 1;435(19):168243. doi: 10.1016/j.jmb.2023.168243. Epub 2023 Aug 22. J Mol Biol. 2023. PMID: 37619706
The high-resolution crystal structure of the EphA8-SASH1 complex provided insights into the specific intermolecular interactions between these proteins. ...We demonstrated that SAM-SAM interaction is critical for SASH1-mediated regulation of EphA8 kinase activity, s …
The high-resolution crystal structure of the EphA8-SASH1 complex provided insights into the specific intermolecular interactions betw …
SASH1 interacts with TNKS2 and promotes human melanocyte stem cell maintenance.
Lambert KA, Clements CM, Mukherjee N, Pacheco TR, Shellman SX, Henen MA, Vögeli B, Goldstein NB, Birlea S, Hintzsche J, Tan AC, Zhao R, Norris DA, Robinson WA, Wang Y, VanTreeck JG, Shellman YG. Lambert KA, et al. bioRxiv [Preprint]. 2023 Sep 27:2023.09.26.559624. doi: 10.1101/2023.09.26.559624. bioRxiv. 2023. PMID: 37808724 Free PMC article. Preprint.
Multiple assays showed that SASH1 binds to tankyrase 2 (TNKS2), which is required for SASH1's promotion of stem-like function. Further, the SASH1 (S519N) variant is in a bona fide Tankyrase-binding motif, and SASH1 (S519N) alters the binding kinetics a …
Multiple assays showed that SASH1 binds to tankyrase 2 (TNKS2), which is required for SASH1's promotion of stem-like function. …
SASH1 knockdown suppresses TRAF6 ubiquitination to regulate hemangioma progression by mediating EZH2 degradation.
Yu X, Cong N, Liu X, Wang R, Li D. Yu X, et al. Exp Cell Res. 2022 Sep 1;418(1):113270. doi: 10.1016/j.yexcr.2022.113270. Epub 2022 Jun 27. Exp Cell Res. 2022. PMID: 35772492
Interestingly, the knockdown of SASH1 enhanced TRAF6 expression but suppressed EZH2 expression in HemECs. And the ubiquitination of EZH2 and TRAF6 was regulated by SASH1. Generally, SASH1 knockdown inhibited TRAF6 ubiquitination to destabilize EZH2. SASH1 …
Interestingly, the knockdown of SASH1 enhanced TRAF6 expression but suppressed EZH2 expression in HemECs. And the ubiquitination of E …
SASH1 contributes to glial cell migration in the early development of the central nervous system.
Zhou Z, Wang P, Wang Q, Dong Z, Chen X, Zhuo R, Wu R, Liu Y, Yang L, Liu M. Zhou Z, et al. Dev Biol. 2023 Dec;504:49-57. doi: 10.1016/j.ydbio.2023.09.006. Epub 2023 Sep 22. Dev Biol. 2023. PMID: 37741309 Free article.
SAM and SH3 domain-containing 1 (SASH1), a member of the SLy protein family, is a tumor suppressor gene that has been studied for its association with various cancers. ...We further performed behavioral experiments in zebrafish larvae that had been injected with sash1a MO …
SAM and SH3 domain-containing 1 (SASH1), a member of the SLy protein family, is a tumor suppressor gene that has been studied for its …
The emerging and diverse roles of the SLy/SASH1-protein family in health and disease-Overview of three multifunctional proteins.
Jaufmann J, Franke FC, Sperlich A, Blumendeller C, Kloos I, Schneider B, Sasaki D, Janssen KP, Beer-Hammer S. Jaufmann J, et al. FASEB J. 2021 Apr;35(4):e21470. doi: 10.1096/fj.202002495R. FASEB J. 2021. PMID: 33710696 Review.
Despite their obvious homology, the three SLy/SASH1-members fundamentally differ with regard to their expression and function in intracellular signaling. ...In this review, we systematically summarize what is known about the SLy/SASH1-adaptors in the field of molecu …
Despite their obvious homology, the three SLy/SASH1-members fundamentally differ with regard to their expression and function in intr …
Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling.
Coulombe P, Paliouras GN, Clayton A, Hussainkhel A, Fuller M, Jovanovic V, Dauphinee S, Umlandt P, Xiang P, Kyle AH, Minchinton AI, Humphries RK, Hoodless PA, Parker JDK, Wright JL, Karsan A. Coulombe P, et al. Cell Rep. 2019 May 7;27(6):1769-1780.e4. doi: 10.1016/j.celrep.2019.04.039. Cell Rep. 2019. PMID: 31067462 Free article.
The sterile alpha motif (SAM) and SRC homology 3 (SH3) domain containing protein 1 (Sash1) acts as a scaffold in TLR4 signaling. We generated Sash1(-/-) mice, which die in the perinatal period due to respiratory distress. ...Thus, we identify a critical cell nonauto …
The sterile alpha motif (SAM) and SRC homology 3 (SH3) domain containing protein 1 (Sash1) acts as a scaffold in TLR4 signaling. We g …
SASH1 is a prognostic indicator and potential therapeutic target in non-small cell lung cancer.
Burgess JT, Bolderson E, Adams MN, Duijf PHG, Zhang SD, Gray SG, Wright G, Richard DJ, O'Byrne KJ. Burgess JT, et al. Sci Rep. 2020 Oct 29;10(1):18605. doi: 10.1038/s41598-020-75625-1. Sci Rep. 2020. PMID: 33122723 Free PMC article.
As these cellular processes are frequently disrupted in human tumours and little is known about the role of SASH1 in the pathogenesis of the disease, we analysed the prognostic value of SASH1 in non-small cell lung cancers using publicly available datasets. ...The t …
As these cellular processes are frequently disrupted in human tumours and little is known about the role of SASH1 in the pathogenesis …
162 results