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Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface.

Jayakar SS, Zhou X, Savechenkov PY, Chiara DC, Desai R, Bruzik KS, Miller KW, Cohen JB. Jayakar SS, et al. Among authors: savechenkov py. J Biol Chem. 2015 Sep 18;290(38):23432-46. doi: 10.1074/jbc.M115.672006. Epub 2015 Jul 30. J Biol Chem. 2015. PMID: 26229099 Free PMC article.

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Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands.

Savechenkov PY, Chiara DC, Desai R, Stern AT, Zhou X, Ziemba AM, Szabo AL, Zhang Y, Cohen JB, Forman SA, Miller KW, Bruzik KS. Savechenkov PY, et al. Eur J Med Chem. 2017 Aug 18;136:334-347. doi: 10.1016/j.ejmech.2017.04.043. Epub 2017 Apr 21. Eur J Med Chem. 2017. PMID: 28505538 Free PMC article.

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A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor.

Yu Z, Chiara DC, Savechenkov PY, Bruzik KS, Cohen JB. Yu Z, et al. Among authors: savechenkov py. J Biol Chem. 2019 May 10;294(19):7892-7903. doi: 10.1074/jbc.RA118.007172. Epub 2019 Mar 28. J Biol Chem. 2019. PMID: 30923128 Free PMC article.

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Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors.

Wu B, Jayakar SS, Zhou X, Titterton K, Chiara DC, Szabo AL, Savechenkov PY, Kent DE, Cohen JB, Forman SA, Miller KW, Bruzik KS. Wu B, et al. Among authors: savechenkov py. Eur J Med Chem. 2019 Jan 15;162:810-824. doi: 10.1016/j.ejmech.2018.11.019. Epub 2018 Nov 19. Eur J Med Chem. 2019. PMID: 30544077 Free PMC article.

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Anion binding modes in meso-substituted hexapyrrolic calix[4]pyrrole isomers.

Chang KC, Minami T, Koutnik P, Savechenkov PY, Liu Y, Anzenbacher P Jr. Chang KC, et al. Among authors: savechenkov py. J Am Chem Soc. 2014 Jan 29;136(4):1520-5. doi: 10.1021/ja411391c. Epub 2014 Jan 17. J Am Chem Soc. 2014. PMID: 24392650

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Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α1β3γ2 GABA_AR Transmembrane Domain.

Jayakar SS, Zhou X, Chiara DC, Jarava-Barrera C, Savechenkov PY, Bruzik KS, Tortosa M, Miller KW, Cohen JB. Jayakar SS, et al. Among authors: savechenkov py. Mol Pharmacol. 2019 Jun;95(6):615-628. doi: 10.1124/mol.118.114975. Epub 2019 Apr 5. Mol Pharmacol. 2019. PMID: 30952799 Free PMC article.

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Binding site location on GABA_A receptors determines whether mixtures of intravenous general anaesthetics interact synergistically or additively in vivo.

Kent DE, Savechenkov PY, Bruzik KS, Miller KW. Kent DE, et al. Among authors: savechenkov py. Br J Pharmacol. 2019 Dec;176(24):4760-4772. doi: 10.1111/bph.14843. Epub 2019 Dec 11. Br J Pharmacol. 2019. PMID: 31454409 Free PMC article.

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p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol.

Stewart DS, Savechenkov PY, Dostalova Z, Chiara DC, Ge R, Raines DE, Cohen JB, Forman SA, Bruzik KS, Miller KW. Stewart DS, et al. Among authors: savechenkov py. J Med Chem. 2011 Dec 8;54(23):8124-35. doi: 10.1021/jm200943f. Epub 2011 Nov 10. J Med Chem. 2011. PMID: 22029276 Free PMC article.

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General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type A Receptors (GABAARs).

Chiara DC, Jounaidi Y, Zhou X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB. Chiara DC, et al. Among authors: savechenkov py. J Biol Chem. 2016 Dec 16;291(51):26529-26539. doi: 10.1074/jbc.M116.753335. Epub 2016 Nov 7. J Biol Chem. 2016. PMID: 27821594 Free PMC article.

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Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.

Savechenkov PY, Zhang X, Chiara DC, Stewart DS, Ge R, Zhou X, Raines DE, Cohen JB, Forman SA, Miller KW, Bruzik KS. Savechenkov PY, et al. J Med Chem. 2012 Jul 26;55(14):6554-65. doi: 10.1021/jm300631e. Epub 2012 Jul 17. J Med Chem. 2012. PMID: 22734650 Free PMC article.

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