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Structure-based inhibitors of tau aggregation.

Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS. Seidler PM, et al. Among authors: sawaya mr. Nat Chem. 2018 Feb;10(2):170-176. doi: 10.1038/nchem.2889. Epub 2017 Nov 20. Nat Chem. 2018. PMID: 29359764 Free PMC article.

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Cryo-EM structures of four polymorphic TDP-43 amyloid cores.

Cao Q, Boyer DR, Sawaya MR, Ge P, Eisenberg DS. Cao Q, et al. Among authors: sawaya mr. Nat Struct Mol Biol. 2019 Jul;26(7):619-627. doi: 10.1038/s41594-019-0248-4. Epub 2019 Jun 24. Nat Struct Mol Biol. 2019. PMID: 31235914 Free PMC article.

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Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core.

Glynn C, Sawaya MR, Ge P, Gallagher-Jones M, Short CW, Bowman R, Apostol M, Zhou ZH, Eisenberg DS, Rodriguez JA. Glynn C, et al. Among authors: sawaya mr. Nat Struct Mol Biol. 2020 May;27(5):417-423. doi: 10.1038/s41594-020-0403-y. Epub 2020 Apr 13. Nat Struct Mol Biol. 2020. PMID: 32284600 Free PMC article.

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Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.

Kato M, Han TW, Xie S, Shi K, Du X, Wu LC, Mirzaei H, Goldsmith EJ, Longgood J, Pei J, Grishin NV, Frantz DE, Schneider JW, Chen S, Li L, Sawaya MR, Eisenberg D, Tycko R, McKnight SL. Kato M, et al. Among authors: sawaya mr. Cell. 2012 May 11;149(4):753-67. doi: 10.1016/j.cell.2012.04.017. Cell. 2012. PMID: 22579281 Free PMC article.

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Structural Studies of Amyloid Proteins at the Molecular Level.

Eisenberg DS, Sawaya MR. Eisenberg DS, et al. Among authors: sawaya mr. Annu Rev Biochem. 2017 Jun 20;86:69-95. doi: 10.1146/annurev-biochem-061516-045104. Epub 2017 Jan 3. Annu Rev Biochem. 2017. PMID: 28125289 Review.

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Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils.

Cao Q, Boyer DR, Sawaya MR, Ge P, Eisenberg DS. Cao Q, et al. Among authors: sawaya mr. Nat Struct Mol Biol. 2020 Jul;27(7):653-659. doi: 10.1038/s41594-020-0435-3. Epub 2020 Jun 15. Nat Struct Mol Biol. 2020. PMID: 32541896

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Structure-based inhibitors of amyloid beta core suggest a common interface with tau.

Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS. Griner SL, et al. Among authors: sawaya mr. Elife. 2019 Oct 15;8:e46924. doi: 10.7554/eLife.46924. Elife. 2019. PMID: 31612856 Free PMC article.

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Structure of the toxic core of α-synuclein from invisible crystals.

Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS. Rodriguez JA, et al. Among authors: sawaya mr. Nature. 2015 Sep 24;525(7570):486-90. doi: 10.1038/nature15368. Epub 2015 Sep 9. Nature. 2015. PMID: 26352473 Free PMC article.

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Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs.

Boyer DR, Li B, Sun C, Fan W, Sawaya MR, Jiang L, Eisenberg DS. Boyer DR, et al. Among authors: sawaya mr. Nat Struct Mol Biol. 2019 Nov;26(11):1044-1052. doi: 10.1038/s41594-019-0322-y. Epub 2019 Nov 6. Nat Struct Mol Biol. 2019. PMID: 31695184 Free PMC article.

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Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel.

Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer DR, Ye S, Eisenberg DS, Zhou ZH, Jiang L. Li B, et al. Among authors: sawaya mr. Nat Commun. 2018 Sep 6;9(1):3609. doi: 10.1038/s41467-018-05971-2. Nat Commun. 2018. PMID: 30190461 Free PMC article.

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