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34 results

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Page 1
SBNO2 is a critical mediator of STAT3-driven hematological malignancies.
Brandstoetter T, Schmoellerl J, Grausenburger R, Kollmann S, Doma E, Huuhtanen J, Klampfl T, Eder T, Grebien F, Hoermann G, Zuber J, Mustjoki S, Maurer B, Sexl V. Brandstoetter T, et al. Blood. 2023 Apr 13;141(15):1831-1845. doi: 10.1182/blood.2022018494. Blood. 2023. PMID: 36630607 Free PMC article.
Among these, strawberry notch homolog 2 (SBNO2) represents an essential transcriptional target, which was identified by a comparative genome-wide CRISPR/Cas9-based loss-of-function screen. ...In patients with NPM-ALK+ T-ALCL, high SBNO2 expression correlates with sh …
Among these, strawberry notch homolog 2 (SBNO2) represents an essential transcriptional target, which was identified by a comparative …
An isoform quantitative trait locus in SBNO2 links genetic susceptibility to Crohn's disease with defective antimicrobial activity.
Aschenbrenner D, Nassiri I, Venkateswaran S, Pandey S, Page M, Drowley L, Armstrong M, Kugathasan S, Fairfax B, Uhlig HH. Aschenbrenner D, et al. Nat Commun. 2024 May 28;15(1):4529. doi: 10.1038/s41467-024-47218-3. Nat Commun. 2024. PMID: 38806456 Free PMC article.
The SBNO2 locus is also differentially methylated in Crohn's disease but the functional mechanisms are unknown. ...The two isoforms of SBNO2 drive differential gene networks with isoform 2 dominantly impacting antimicrobial activity in macrophages. ...
The SBNO2 locus is also differentially methylated in Crohn's disease but the functional mechanisms are unknown. ...The two isoforms o …
Gender-specific SBNO2 and VPS13B as a potential driver of osteoporosis development in male ankylosing spondylitis.
Li T, Liu WB, Tian FF, Jiang JJ, Wang Q, Hu FQ, Hu WH, Zhang XS. Li T, et al. Osteoporos Int. 2021 Feb;32(2):311-320. doi: 10.1007/s00198-020-05593-9. Epub 2020 Aug 15. Osteoporos Int. 2021. PMID: 32803317
Analysis of the two modules revealed VPS13B and SBNO2 as key genes due to the high degree of correlation. Both genes play an important role in bone metabolism regulation in male AS. Two hub genes MYD88 in MEblue and NCK1 in MEred with high degree of connectivity were selec …
Analysis of the two modules revealed VPS13B and SBNO2 as key genes due to the high degree of correlation. Both genes play an importan …
Strawberry notch homolog 2 regulates the response to interleukin-6 in the central nervous system.
Syme TE, Grill M, Hayashida E, Viengkhou B, Campbell IL, Hofer MJ. Syme TE, et al. J Neuroinflammation. 2022 May 27;19(1):126. doi: 10.1186/s12974-022-02475-1. J Neuroinflammation. 2022. PMID: 35624480 Free PMC article.
METHODS: Mice with germline disruption of Sbno2 (Sbno2(-/-)) were generated and crossed with transgenic mice with chronic astrocyte production of IL-6 (GFAP-IL6). Phenotypic, molecular and transcriptomic analyses were performed on tissues and primary cell cultures t …
METHODS: Mice with germline disruption of Sbno2 (Sbno2(-/-)) were generated and crossed with transgenic mice with chronic astr …
Study of Strawberry Notch homolog 1 and 2 expression in human glioblastoma.
Coppieters N, Scalisi J, Digregorio M, Leparc L, Velazquez Saez L, Lombard A, Rogister B, Neirinckx V. Coppieters N, et al. J Neurooncol. 2023 Feb;161(3):515-523. doi: 10.1007/s11060-023-04240-7. Epub 2023 Jan 25. J Neurooncol. 2023. PMID: 36695974
We located SBNO1 and SBNO2 in different subcellular compartments. Finally, we observed that SBNO2 overexpression induces different phenotypes in different patient-derived GSCs. CONCLUSION: These results provide the first characterization of SBNO1 and SBNO2 ex …
We located SBNO1 and SBNO2 in different subcellular compartments. Finally, we observed that SBNO2 overexpression induces diffe …
Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.
Maruyama K, Uematsu S, Kondo T, Takeuchi O, Martino MM, Kawasaki T, Akira S. Maruyama K, et al. J Exp Med. 2013 Sep 23;210(10):1947-60. doi: 10.1084/jem.20130512. Epub 2013 Aug 26. J Exp Med. 2013. PMID: 23980096 Free PMC article.
We found that RANKL induced expression of the DExD/H helicase family corepressor strawberry notch homologue 2 (Sbno2). Previous in vitro studies showed that Sbno2 is induced by IL-10 and is involved in NF-kappaB repression. However, the role of Sbno2 in vivo …
We found that RANKL induced expression of the DExD/H helicase family corepressor strawberry notch homologue 2 (Sbno2). Previous in vi …
Systematic Identification of Key Functional Modules and Genes in Gastric Cancer.
Wu R, Sun JY, Zhao LL, Fan ZN, Yang C. Wu R, et al. Biomed Res Int. 2020 Nov 16;2020:8853348. doi: 10.1155/2020/8853348. eCollection 2020. Biomed Res Int. 2020. PMID: 33282955 Free PMC article.
The purple module was identified as the hub module in WGCNA. SBNO2 was identified as the hub gene, which was upregulated in tumour tissues. Moreover, patients with GC and higher SBNO2 expression had worse prognoses. In addition, SBNO2 was suggested to play an …
The purple module was identified as the hub module in WGCNA. SBNO2 was identified as the hub gene, which was upregulated in tumour ti …
Utilizing systematic Mendelian randomization to identify potential therapeutic targets for mania.
Xu FB, Hu S, Wang JJ, Wang XZ. Xu FB, et al. Front Psychiatry. 2024 Mar 5;15:1375209. doi: 10.3389/fpsyt.2024.1375209. eCollection 2024. Front Psychiatry. 2024. PMID: 38505796 Free PMC article.
MR revealed phenylalanine to be the only key substance that has a unidirectional causal relationship with mania. In the end, SBNO2, PBX2, RAMP3, and QPCT, which are significantly associated with the phenylalanine metabolism pathway, were identified as drug target genes. CO …
MR revealed phenylalanine to be the only key substance that has a unidirectional causal relationship with mania. In the end, SBNO2, P …
Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system.
Grill M, Syme TE, Noçon AL, Lu AZ, Hancock D, Rose-John S, Campbell IL. Grill M, et al. Glia. 2015 Oct;63(10):1738-52. doi: 10.1002/glia.22841. Epub 2015 Apr 22. Glia. 2015. PMID: 25903009 Free PMC article.
These changes were reflected by corresponding alterations in the level of the SBNO2 protein. Inhibiting protein synthesis resulted in higher Sbno2 mRNA and did not abolish the upregulation of Sbno2 mRNA mediated by hyper-IL-6. Inhibition of transcription led …
These changes were reflected by corresponding alterations in the level of the SBNO2 protein. Inhibiting protein synthesis resulted in …
Single-cell analysis of CD4+ tissue residency memory cells (TRMs) in adult atopic dermatitis: A new potential mechanism.
Bai W, Yang L, Qiu J, Zhu Z, Wang S, Li P, Zhou D, Wang H, Liao Y, Yu Y, Yang Z, Wen P, Zhang D. Bai W, et al. Genomics. 2024 Jul;116(4):110870. doi: 10.1016/j.ygeno.2024.110870. Epub 2024 May 29. Genomics. 2024. PMID: 38821220 Free article.
The significant relationship between CD4(+) TRM and AD was assessed through further analyses. FOXO1 and SBNO2, two of the 13 hub genes, were characteristically expressed in the CD4(+) TRM, but down-regulated in IFN-gamma/TNF-alpha-induced HaCaT cells, as shown using quanti …
The significant relationship between CD4(+) TRM and AD was assessed through further analyses. FOXO1 and SBNO2, two of the 13 hub gene …
34 results