Thiazolopyridine ureas as novel antitubercular agents acting through inhibition of DNA Gyrase B.
Kale MG, Raichurkar A, P SH, Waterson D, McKinney D, Manjunatha MR, Kranthi U, Koushik K, Jena Lk, Shinde V, Rudrapatna S, Barde S, Humnabadkar V, Madhavapeddi P, Basavarajappa H, Ghosh A, Ramya VK, Guptha S, Sharma S, Vachaspati P, Kumar KN, Giridhar J, Reddy J, Panduga V, Ganguly S, Ahuja V, Gaonkar S, Kumar CN, Ogg D, Tucker JA, Boriack-Sjodin PA, de Sousa SM, Sambandamurthy VK, Ghorpade SR.
Kale MG, et al. Among authors: p sh.
J Med Chem. 2013 Nov 14;56(21):8834-48. doi: 10.1021/jm401268f. Epub 2013 Oct 18.
J Med Chem. 2013.
PMID: 24088190
A pharmacophore-based search led to the identification of thiazolopyridine ureas as a novel scaffold with antitubercular activity acting through inhibition of DNA Gyrase B (GyrB) ATPase. ...
A pharmacophore-based search led to the identification of thiazolopyridine ureas as a novel scaffold with antitubercular activity act …