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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1951 1
1965 1
1966 1
1967 1
1968 1
1970 1
1971 6
1972 4
1973 3
1974 1
1975 1
1976 2
1979 1
1980 3
1981 1
1983 3
1985 2
1986 1
1987 1
1988 2
1989 1
1991 3
1994 2
1996 1
1998 3
1999 7
2000 4
2001 4
2002 4
2003 1
2004 1
2005 2
2006 6
2007 10
2008 11
2009 11
2010 8
2011 13
2012 18
2013 21
2014 16
2015 12
2016 17
2017 15
2018 15
2019 17
2020 16
2021 21
2022 24
2023 18
2024 10

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321 results

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Page 1
Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates.
Brown CR, Gupta S, Qin J, Racie T, He G, Lentini S, Malone R, Yu M, Matsuda S, Shulga-Morskaya S, Nair AV, Theile CS, Schmidt K, Shahraz A, Goel V, Parmar RG, Zlatev I, Schlegel MK, Nair JK, Jayaraman M, Manoharan M, Brown D, Maier MA, Jadhav V. Brown CR, et al. Among authors: schlegel mk. Nucleic Acids Res. 2020 Dec 2;48(21):11827-11844. doi: 10.1093/nar/gkaa670. Nucleic Acids Res. 2020. PMID: 32808038 Free PMC article.
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.
Brown KM, Nair JK, Janas MM, Anglero-Rodriguez YI, Dang LTH, Peng H, Theile CS, Castellanos-Rizaldos E, Brown C, Foster D, Kurz J, Allen J, Maganti R, Li J, Matsuda S, Stricos M, Chickering T, Jung M, Wassarman K, Rollins J, Woods L, Kelin A, Guenther DC, Mobley MW, Petrulis J, McDougall R, Racie T, Bombardier J, Cha D, Agarwal S, Johnson L, Jiang Y, Lentini S, Gilbert J, Nguyen T, Chigas S, LeBlanc S, Poreci U, Kasper A, Rogers AB, Chong S, Davis W, Sutherland JE, Castoreno A, Milstein S, Schlegel MK, Zlatev I, Charisse K, Keating M, Manoharan M, Fitzgerald K, Wu JT, Maier MA, Jadhav V. Brown KM, et al. Among authors: schlegel mk. Nat Biotechnol. 2022 Oct;40(10):1500-1508. doi: 10.1038/s41587-022-01334-x. Epub 2022 Jun 2. Nat Biotechnol. 2022. PMID: 35654979
Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates.
Foster DJ, Brown CR, Shaikh S, Trapp C, Schlegel MK, Qian K, Sehgal A, Rajeev KG, Jadhav V, Manoharan M, Kuchimanchi S, Maier MA, Milstein S. Foster DJ, et al. Among authors: schlegel mk. Mol Ther. 2018 Mar 7;26(3):708-717. doi: 10.1016/j.ymthe.2017.12.021. Epub 2018 Jan 4. Mol Ther. 2018. PMID: 29456020 Free PMC article.
Evolution of mammals and their gut microbes.
Ley RE, Hamady M, Lozupone C, Turnbaugh PJ, Ramey RR, Bircher JS, Schlegel ML, Tucker TA, Schrenzel MD, Knight R, Gordon JI. Ley RE, et al. Among authors: schlegel ml. Science. 2008 Jun 20;320(5883):1647-51. doi: 10.1126/science.1155725. Epub 2008 May 22. Science. 2008. PMID: 18497261 Free PMC article.
Myocardial infarction accelerates breast cancer via innate immune reprogramming.
Koelwyn GJ, Newman AAC, Afonso MS, van Solingen C, Corr EM, Brown EJ, Albers KB, Yamaguchi N, Narke D, Schlegel M, Sharma M, Shanley LC, Barrett TJ, Rahman K, Mezzano V, Fisher EA, Park DS, Newman JD, Quail DF, Nelson ER, Caan BJ, Jones LW, Moore KJ. Koelwyn GJ, et al. Among authors: schlegel m. Nat Med. 2020 Sep;26(9):1452-1458. doi: 10.1038/s41591-020-0964-7. Epub 2020 Jul 13. Nat Med. 2020. PMID: 32661390 Free PMC article.
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.
Schlegel MK, Janas MM, Jiang Y, Barry JD, Davis W, Agarwal S, Berman D, Brown CR, Castoreno A, LeBlanc S, Liebow A, Mayo T, Milstein S, Nguyen T, Shulga-Morskaya S, Hyde S, Schofield S, Szeto J, Woods LB, Yilmaz VO, Manoharan M, Egli M, Charissé K, Sepp-Lorenzino L, Haslett P, Fitzgerald K, Jadhav V, Maier MA. Schlegel MK, et al. Nucleic Acids Res. 2022 Jul 8;50(12):6656-6670. doi: 10.1093/nar/gkac539. Nucleic Acids Res. 2022. PMID: 35736224 Free PMC article.
Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression.
Sharma M, Schlegel MP, Afonso MS, Brown EJ, Rahman K, Weinstock A, Sansbury BE, Corr EM, van Solingen C, Koelwyn GJ, Shanley LC, Beckett L, Peled D, Lafaille JJ, Spite M, Loke P, Fisher EA, Moore KJ. Sharma M, et al. Among authors: schlegel mp. Circ Res. 2020 Jul 17;127(3):335-353. doi: 10.1161/CIRCRESAHA.119.316461. Epub 2020 Apr 27. Circ Res. 2020. PMID: 32336197 Free PMC article.
Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.
Janas MM, Schlegel MK, Harbison CE, Yilmaz VO, Jiang Y, Parmar R, Zlatev I, Castoreno A, Xu H, Shulga-Morskaya S, Rajeev KG, Manoharan M, Keirstead ND, Maier MA, Jadhav V. Janas MM, et al. Among authors: schlegel mk. Nat Commun. 2018 Feb 19;9(1):723. doi: 10.1038/s41467-018-02989-4. Nat Commun. 2018. PMID: 29459660 Free PMC article.
RNAs Containing Carbocyclic Ribonucleotides.
Akabane-Nakata M, Chickering T, Harp JM, Schlegel MK, Matsuda S, Egli M, Manoharan M. Akabane-Nakata M, et al. Among authors: schlegel mk. Org Lett. 2022 Jan 21;24(2):525-530. doi: 10.1021/acs.orglett.1c03936. Epub 2021 Dec 27. Org Lett. 2022. PMID: 34958225
321 results