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85 results

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Page 1
BET bromodomain inhibitors.
Schwalm MP, Knapp S. Schwalm MP, et al. Curr Opin Chem Biol. 2022 Jun;68:102148. doi: 10.1016/j.cbpa.2022.102148. Epub 2022 Apr 21. Curr Opin Chem Biol. 2022. PMID: 35462054 Review.
Inhibitors supercharge kinase turnover through native proteolytic circuits.
Scholes NS, Bertoni M, Comajuncosa-Creus A, Kladnik K, Guo X, Frommelt F, Hinterndorfer M, Razumkov H, Prokofeva P, Schwalm MP, Born F, Roehm S, Imrichova H, Santini BL, Barone E, Schätz C, Muñoz I Ordoño M, Lechner S, Rukavina A, Serrano I, Abele M, Koren A, Kubicek S, Knapp S, Gray NS, Superti-Furga G, Kuster B, Shi Y, Aloy P, Winter GE. Scholes NS, et al. Among authors: schwalm mp. Nature. 2025 Nov 26. doi: 10.1038/s41586-025-09763-9. Online ahead of print. Nature. 2025. PMID: 41299171
Texaphyrin-Based Calcium Sensor for Multimodal Imaging.
Thiabaud GD, Schwalm M, Sen S, Barandov A, Simon J, Harvey P, Spanoudaki V, Müller P, Sessler JL, Jasanoff A. Thiabaud GD, et al. Among authors: schwalm m. ACS Sens. 2023 Oct 27;8(10):3855-3861. doi: 10.1021/acssensors.3c01387. Epub 2023 Oct 9. ACS Sens. 2023. PMID: 37812688 Free PMC article.
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets.
Schwalm MP, Dopfer J, Kumar A, Greco FA, Bauer N, Löhr F, Heering J, Cano-Franco S, Lechner S, Hanke T, Jaser I, Morasch V, Lenz C, Fearon D, Marples PG, Tomlinson CWE, Brunello L, Saxena K, Adams NBP, von Delft F, Müller S, Stolz A, Proschak E, Kuster B, Knapp S, Rogov VV. Schwalm MP, et al. Nat Commun. 2024 Nov 25;15(1):10204. doi: 10.1038/s41467-024-54409-5. Nat Commun. 2024. PMID: 39587067 Free PMC article.
Type II kinase inhibitors that target Parkinson's disease-associated LRRK2.
Raig ND, Surridge KJ, Sanz-Murillo M, Dederer V, Krämer A, Schwalm MP, Lattal NM, Elson L, Chatterjee D, Mathea S, Hanke T, Leschziner AE, Reck-Peterson SL, Knapp S. Raig ND, et al. Among authors: schwalm mp. Sci Adv. 2025 Jun 6;11(23):eadt2050. doi: 10.1126/sciadv.adt2050. Epub 2025 Jun 4. Sci Adv. 2025. PMID: 40465731 Free PMC article.
A chemical probe to modulate human GID4 Pro/N-degron interactions.
Owens DDG, Maitland MER, Khalili Yazdi A, Song X, Reber V, Schwalm MP, Machado RAC, Bauer N, Wang X, Szewczyk MM, Dong C, Dong A, Loppnau P, Calabrese MF, Dowling MS, Lee J, Montgomery JI, O'Connell TN, Subramanyam C, Wang F, Adamson EC, Schapira M, Gstaiger M, Knapp S, Vedadi M, Min J, Lajoie GA, Barsyte-Lovejoy D, Owen DR, Schild-Poulter C, Arrowsmith CH. Owens DDG, et al. Among authors: schwalm mp. Nat Chem Biol. 2024 Sep;20(9):1164-1175. doi: 10.1038/s41589-024-01618-0. Epub 2024 May 21. Nat Chem Biol. 2024. PMID: 38773330
Workflow for E3 Ligase Ligand Validation for PROTAC Development.
Miletić N, Weckesser J, Mosler T, Rathore R, Hoffmann ME, Gehrtz P, Schlesiger S, Hartung IV, Berner N, Wilhelm S, Müller J, Adhikari B, Němec V, Sivashanmugam SA, Elson L, Holzmann H, Schwalm MP, Hoffmann L, Abdul Azeez KR, Müller S, Kuster B, Wolf E, Đikić I, Knapp S. Miletić N, et al. Among authors: schwalm mp. ACS Chem Biol. 2025 Feb 21;20(2):507-521. doi: 10.1021/acschembio.4c00812. Epub 2025 Feb 11. ACS Chem Biol. 2025. PMID: 39932098 Free PMC article.
Inhibition of DYRK1B BY C81 impedes inflammatory processes in leukocytes by reducing STAT3 activity.
Ciurus S, Elewa MAF, Palmer MA, Wolf A, Hector M, Fuhrmann DC, Thomas D, Gurke R, Schwalm MP, Berger L, Zech TJ, Burgers LD, Marschalek R, Geisslinger G, Knapp S, Langmann T, Bracher F, Weigert A, Fürst R. Ciurus S, et al. Among authors: schwalm mp. Cell Mol Life Sci. 2025 Feb 22;82(1):85. doi: 10.1007/s00018-025-05579-y. Cell Mol Life Sci. 2025. PMID: 39985685 Free PMC article.
85 results