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31 results

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Page 1
Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models.
Yang L, Han B, Zhang Z, Wang S, Bai Y, Zhang Y, Tang Y, Du L, Xu L, Wu F, Zuo L, Chen X, Lin Y, Liu K, Ye Q, Chen B, Li B, Tang T, Wang Y, Shen L, Wang G, Ju M, Yuan M, Jiang W, Zhang JH, Hu G, Wang J, Yao H. Yang L, et al. Circulation. 2020 Aug 11;142(6):556-574. doi: 10.1161/CIRCULATIONAHA.120.045765. Epub 2020 May 22. Circulation. 2020. PMID: 32441115
Lentivirus-based expression systems have been widely used in basic studies of circRNAs, but safety issues with such delivery systems have limited exploration of the potential therapeutic roles for circRNAs. METHODS: Circular RNA SCMH1 (circSCMH1) was screened from the plas …
Lentivirus-based expression systems have been widely used in basic studies of circRNAs, but safety issues with such delivery systems have li …
FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.
Li B, Xi W, Bai Y, Liu X, Zhang Y, Li L, Bian L, Liu C, Tang Y, Shen L, Yang L, Gu X, Xie J, Zhou Z, Wang Y, Yu X, Wang J, Chao J, Han B, Yao H. Li B, et al. Nat Commun. 2023 Jan 30;14(1):489. doi: 10.1038/s41467-023-36008-y. Nat Commun. 2023. PMID: 36717587 Free PMC article.
N(6)-methyladenosine (m(6)A), the most prevalent internal modification in eukaryotic mRNAs, functionally mediates vascular repair. However, whether circular RNA SCMH1 (circSCMH1) promotes vascular repair by m(6)A methylation after stroke remains to be elucidated. ...
N(6)-methyladenosine (m(6)A), the most prevalent internal modification in eukaryotic mRNAs, functionally mediates vascular repair. However, …
Blocking circ-SCMH1 (hsa_circ_0011946) suppresses acquired DDP resistance of oral squamous cell carcinoma (OSCC) cells both in vitro and in vivo by sponging miR-338-3p and regulating LIN28B.
Qiu F, Qiao B, Zhang N, Fang Z, Feng L, Zhang S, Qiu W. Qiu F, et al. Cancer Cell Int. 2021 Aug 5;21(1):412. doi: 10.1186/s12935-021-02110-8. Cancer Cell Int. 2021. PMID: 34353342 Free PMC article.
Notably, circ-SCMH1 was an EVs cargo, and DDP-resistant OSCC cells-derived EVs could provoke circ-SCMH1 upregulation in parental cells. CONCLUSION: Circ-SCMH1 contributes to chemoresistance of DDP-resistant OSCC cells partially via EVs secretion and circ-S …
Notably, circ-SCMH1 was an EVs cargo, and DDP-resistant OSCC cells-derived EVs could provoke circ-SCMH1 upregulation in parent …
Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4.
Yasunaga S, Ohtsubo M, Ohno Y, Saeki K, Kurogi T, Tanaka-Okamoto M, Ishizaki H, Shirai M, Mihara K, Brock HW, Miyoshi J, Takihara Y. Yasunaga S, et al. Mol Cell Biol. 2013 Feb;33(4):644-60. doi: 10.1128/MCB.00974-12. Epub 2012 Dec 3. Mol Cell Biol. 2013. PMID: 23207902 Free PMC article.
Scmh1 is unstable and regulated through the ubiquitin-proteasome system, but its molecular roles are unknown, so we generated Scmh1-deficient mice to elucidate its function. ...Age-related transcriptional downregulation of derepressed Hoxa9 also leads to geminin acc …
Scmh1 is unstable and regulated through the ubiquitin-proteasome system, but its molecular roles are unknown, so we generated Scmh …
Transcriptome sequencing of circular RNA reveals the involvement of hsa-SCMH1_0001 in the pathogenesis of Parkinson's disease.
Wang Q, Wang H, Zhao X, Han C, Liu C, Li Z, Du T, Sui Y, Zhang X, Zhang J, Xiao Y, Cai G, Meng F. Wang Q, et al. CNS Neurosci Ther. 2024 Mar;30(3):e14435. doi: 10.1111/cns.14435. Epub 2023 Sep 4. CNS Neurosci Ther. 2024. PMID: 37664885 Free PMC article.
RESULTS: According to the NGS, 62 upregulated and 37 downregulated circRNAs in the PD group were screened out. Correlation analysis revealed that hsa-SCMH1_0001 has strong clinical relevance. We identified 17 potential binding miRNAs of hsa-SCMH1_0001 with 149 poten …
RESULTS: According to the NGS, 62 upregulated and 37 downregulated circRNAs in the PD group were screened out. Correlation analysis revealed …
31 results