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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 3
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209 results

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Page 1
Distinct effects of SDC3 and FGFRL1 on selective neurodegeneration in AD and PD.
Wang J, Chen P, Hu B, Cai F, Xu Q, Pan S, Wu Y, Song W. Wang J, et al. FASEB J. 2023 Feb;37(2):e22773. doi: 10.1096/fj.202201359R. FASEB J. 2023. PMID: 36629784
Finally, the knockdown of SDC3 and FGFRL1 attenuated oxidative stress-induced cell death in SN56-APP(SWE) and MN9D-SNCAA53T cells. ...Our study suggests that SDC3 and FGFRL1 could be potential targets to alleviate the selective neurodegeneration in AD and PD....
Finally, the knockdown of SDC3 and FGFRL1 attenuated oxidative stress-induced cell death in SN56-APP(SWE) and MN9D-SNCAA53T cells. .. …
Spatial transcriptomics identifies enriched gene expression and cell types in human liver fibrosis.
Chung BK, Øgaard J, Reims HM, Karlsen TH, Melum E. Chung BK, et al. Hepatol Commun. 2022 Sep;6(9):2538-2550. doi: 10.1002/hep4.2001. Epub 2022 Jun 20. Hepatol Commun. 2022. PMID: 35726350 Free PMC article.
Deconvolution and enumeration of parenchymal and fibrotic gene content as measured by spatial transcriptomics into distinct cell states revealed significantly higher frequencies of ACTA2+ FABP4+ and COL3A1+ mesenchymal cells, IL17RA+ S100A8+ and FCER1G+ tissue monocytes, VCAM1+ …
Deconvolution and enumeration of parenchymal and fibrotic gene content as measured by spatial transcriptomics into distinct cell states reve …
Syndecan-3 positively regulates the pro-inflammatory function of macrophages.
Lee SY, Prieto-Fernández E, Egia-Mendikute L, Antoñana-Vildosola A, Velasco-Beltrán P, Bosch A, Jimenez-Lasheras B, de Blas A, Etxaniz-Diaz de Durana J, Valdaliso-Díez E, Bozal-Basterra L, Ercilla A, Martin JE, Carracedo A, Gros A, Aransay AM, Palazón A, Pérez-Gutiérrez L. Lee SY, et al. Cell Mol Life Sci. 2025 Apr 7;82(1):145. doi: 10.1007/s00018-025-05649-1. Cell Mol Life Sci. 2025. PMID: 40192763 Free PMC article.
Here, we demonstrated that pro-inflammatory cytokines drive the expression of SDC3 on the cell surface of macrophages. Genetic ablation of SDC3 in macrophages led to aberrant proliferation, adhesion and expression of CD40 and CD86 surface markers. ...Mechanistically …
Here, we demonstrated that pro-inflammatory cytokines drive the expression of SDC3 on the cell surface of macrophages. Genetic ablati …
The Role of the Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 in Breast Cancer Pathophysiology.
Habenicht L, Hassan N, Espinoza-Sànchez NA, Onyeisi JOS, Győrffy B, Hanker L, Greve B, Götte M. Habenicht L, et al. Cells. 2025 Oct 17;14(20):1612. doi: 10.3390/cells14201612. Cells. 2025. PMID: 41148827 Free PMC article.
The heparan sulfate proteoglycan syndecan-3 (SDC3) is a critical regulator of cell-matrix interactions. While other syndecan family members contribute to the progression of multiple cancers, SDC3's functional contributions to tumor biology remain largely unexplored. …
The heparan sulfate proteoglycan syndecan-3 (SDC3) is a critical regulator of cell-matrix interactions. While other syndecan family m …
A genome-wide association study identifies a novel association between SDC3 and apparent treatment-resistant hypertension.
Xiao X, Li R, Wu C, Yan Y, Yuan M, Cui B, Zhang Y, Zhang C, Zhang X, Zhang W, Hui R, Wang Y. Xiao X, et al. BMC Med. 2022 Nov 30;20(1):463. doi: 10.1186/s12916-022-02665-x. BMC Med. 2022. PMID: 36447229 Free PMC article.
The 23 significant SNPs were in or near LAPTM5, SDC3, UGT2A1, FTMT, and NIPA1. eQTL analysis uncovered 14 SNPs in 1p35 locus all had same regulation directions for SDC3 and LAPTM5. ...RT-qPCR assay further verified the lower expression of SDC3 in aTRH. CONCLU …
The 23 significant SNPs were in or near LAPTM5, SDC3, UGT2A1, FTMT, and NIPA1. eQTL analysis uncovered 14 SNPs in 1p35 locus all had …
Leukocyte-epithelial interactions.
Zen K, Parkos CA. Zen K, et al. Curr Opin Cell Biol. 2003 Oct;15(5):557-64. doi: 10.1016/s0955-0674(03)00103-0. Curr Opin Cell Biol. 2003. PMID: 14519390 Review.
Co-Aggregation of Syndecan-3 with β-Amyloid Aggravates Neuroinflammation and Cognitive Impairment in 5×FAD Mice.
Ye F, Li M, Liu M, Wu X, Tian F, Gong Y, Cao Y, Zhang J, Zhang X, Qin C, Zhang L. Ye F, et al. Int J Mol Sci. 2025 Jun 8;26(12):5502. doi: 10.3390/ijms26125502. Int J Mol Sci. 2025. PMID: 40564963 Free PMC article.
In this study, a 5 FAD mouse model with downregulated SDC3 expression was constructed. Behavioral assessments and synaptic function tests were performed to explore the effects of SDC3 on cognition in 5 FAD mice. ...This study reveals that SDC3 co-localizes wi …
In this study, a 5 FAD mouse model with downregulated SDC3 expression was constructed. Behavioral assessments and synaptic function t …
LncRNA TRPM2-AS promotes ovarian cancer progression and cisplatin resistance by sponging miR-138-5p to release SDC3 mRNA.
Ding Y, Tan X, Abasi A, Dai Y, Wu R, Zhang T, Li K, Yan M, Huang X. Ding Y, et al. Aging (Albany NY). 2021 Feb 17;13(5):6832-6848. doi: 10.18632/aging.202541. Epub 2021 Feb 17. Aging (Albany NY). 2021. PMID: 33621194 Free PMC article.
The western blot assay was utilized to detect the SDC3 protein expression and cell-apoptosis markers. Luciferase reporter gene assay, RIP, and RNA pull-down assays were performed to identify the association between TRPM2-AS, miR-138-5p and SDC3. ...Unlike miR-138-5p …
The western blot assay was utilized to detect the SDC3 protein expression and cell-apoptosis markers. Luciferase reporter gene assay, …
CircRNA SCARB1 Promotes Renal Cell Carcinoma Progression Via Mir- 510-5p/SDC3 Axis.
Sun J, Pan S, Cui H, Li H. Sun J, et al. Curr Cancer Drug Targets. 2020;20(6):461-470. doi: 10.2174/1568009620666200409130032. Curr Cancer Drug Targets. 2020. PMID: 32271695
MiR-510-5p was confirmed to be a target of Circ-SCARB1; inhibition of cell progression by silencing Circ-SCARB1 was mediated by a direct interaction between Circ-SCARB1 and miR-510-5p. SDC3 was verified to be a gene target of miR-510-5p; transfection of miR-510-5p mimic no …
MiR-510-5p was confirmed to be a target of Circ-SCARB1; inhibition of cell progression by silencing Circ-SCARB1 was mediated by a direct int …
Syndecan-3 in Inflammation and Angiogenesis.
Arokiasamy S, Balderstone MJM, De Rossi G, Whiteford JR. Arokiasamy S, et al. Front Immunol. 2020 Jan 9;10:3031. doi: 10.3389/fimmu.2019.03031. eCollection 2019. Front Immunol. 2020. PMID: 31998313 Free PMC article. Review.
SDC3 null mice grow and develop normally, all be it with subtle anatomical phenotypes in the brain. ...The purpose of this review article is to explore these new biological insights into SDC3 functions in inflammatory disease....
SDC3 null mice grow and develop normally, all be it with subtle anatomical phenotypes in the brain. ...The purpose of this review art …
209 results