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Advancing therapies for viral infections using mechanistic computational models of the dynamic interplay between the virus and host immune response.

Zarnitsyna VI, Gianlupi JF, Hagar A, Sego TJ, Glazier JA. Zarnitsyna VI, et al. Among authors: sego tj. Curr Opin Virol. 2021 Oct;50:103-109. doi: 10.1016/j.coviro.2021.07.007. Epub 2021 Aug 24. Curr Opin Virol. 2021. PMID: 34450519 Free PMC article. Review.

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Compartmental Model Suggests Importance of Innate Immune Response to COVID-19 Infection in Rhesus Macaques.

Mochan E, Sego TJ, Gaona L, Rial E, Ermentrout GB. Mochan E, et al. Among authors: sego tj. Bull Math Biol. 2021 May 26;83(7):79. doi: 10.1007/s11538-021-00909-0. Bull Math Biol. 2021. PMID: 34037874 Free PMC article.

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Computational fluid dynamic analysis of bioprinted self-supporting perfused tissue models.

Sego TJ, Prideaux M, Sterner J, McCarthy BP, Li P, Bonewald LF, Ekser B, Tovar A, Jeshua Smith L. Sego TJ, et al. Biotechnol Bioeng. 2020 Mar;117(3):798-815. doi: 10.1002/bit.27238. Epub 2019 Dec 18. Biotechnol Bioeng. 2020. PMID: 31788785 Free PMC article.

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Multicellular spatial model of RNA virus replication and interferon responses reveals factors controlling plaque growth dynamics.

Aponte-Serrano JO, Weaver JJA, Sego TJ, Glazier JA, Shoemaker JE. Aponte-Serrano JO, et al. Among authors: sego tj. PLoS Comput Biol. 2021 Oct 25;17(10):e1008874. doi: 10.1371/journal.pcbi.1008874. eCollection 2021 Oct. PLoS Comput Biol. 2021. PMID: 34695114 Free PMC article.

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Generation of multicellular spatiotemporal models of population dynamics from ordinary differential equations, with applications in viral infection.

Sego TJ, Aponte-Serrano JO, Gianlupi JF, Glazier JA. Sego TJ, et al. BMC Biol. 2021 Sep 8;19(1):196. doi: 10.1186/s12915-021-01115-z. BMC Biol. 2021. PMID: 34496857 Free PMC article.

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Unification of aggregate growth models by emergence from cellular and intracellular mechanisms.

Sego TJ, Glazier JA, Tovar A. Sego TJ, et al. R Soc Open Sci. 2020 Aug 12;7(8):192148. doi: 10.1098/rsos.192148. eCollection 2020 Aug. R Soc Open Sci. 2020. PMID: 32968501 Free PMC article.

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Modeling Progressive Damage Accumulation in Bone Remodeling Explains the Thermodynamic Basis of Bone Resorption by Overloading.

Sego TJ, Hsu YT, Chu TM, Tovar A. Sego TJ, et al. Bull Math Biol. 2020 Oct 10;82(10):134. doi: 10.1007/s11538-020-00808-w. Bull Math Biol. 2020. PMID: 33037933

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Building digital twins of the human immune system: toward a roadmap.

Laubenbacher R, Niarakis A, Helikar T, An G, Shapiro B, Malik-Sheriff RS, Sego TJ, Knapp A, Macklin P, Glazier JA. Laubenbacher R, et al. Among authors: sego tj. NPJ Digit Med. 2022 May 20;5(1):64. doi: 10.1038/s41746-022-00610-z. NPJ Digit Med. 2022. PMID: 35595830 Free PMC article. Review.

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A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness.

Sego TJ, Aponte-Serrano JO, Ferrari Gianlupi J, Heaps SR, Breithaupt K, Brusch L, Crawshaw J, Osborne JM, Quardokus EM, Plemper RK, Glazier JA. Sego TJ, et al. PLoS Comput Biol. 2020 Dec 21;16(12):e1008451. doi: 10.1371/journal.pcbi.1008451. eCollection 2020 Dec. PLoS Comput Biol. 2020. PMID: 33347439 Free PMC article.

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A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness: A multiscale model of viral infection in epithelial tissues.

Sego TJ, Aponte-Serrano JO, Gianlupi JF, Heaps SR, Breithaupt K, Brusch L, Crawshaw J, Osborne JM, Quardokus EM, Plemper RK, Glazier JA. Sego TJ, et al. bioRxiv. 2020 Sep 26:2020.04.27.064139. doi: 10.1101/2020.04.27.064139. Preprint. bioRxiv. 2020. PMID: 32511367 Free PMC article. Updated.

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