Semple G[au] - Search Results

Year	Number of Results
1996	1
1997	2
1998	2
2001	2
2002	1
2003	2
2005	4
2006	2
2007	8
2008	7
2009	4
2010	4
2011	4
2012	5
2014	3
2015	4
2016	2
2017	2
2018	2
2019	1
2020	1
2021	1
2022	1

1

Nicotinic acid receptor agonists.

Boatman PD, Richman JG, Semple G. Boatman PD, et al. Among authors: semple g. J Med Chem. 2008 Dec 25;51(24):7653-62. doi: 10.1021/jm800896z. J Med Chem. 2008. PMID: 18983141 Review. No abstract available.

2

Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT_2C receptor.

Schrader TO, Zhu X, Kasem M, Ren A, Liu C, Wu C, Dang H, Le M, Gatlin J, Chase K, Frazer J, Whelan KT, Grottick AJ, Hutton C, Barden J, Chen C, Ortiz A, Feichtinger K, Semple G. Schrader TO, et al. Among authors: semple g. Bioorg Med Chem Lett. 2021 Apr 15;38:127872. doi: 10.1016/j.bmcl.2021.127872. Epub 2021 Feb 23. Bioorg Med Chem Lett. 2021. PMID: 33636307

3

Recent progress in the discovery of niacin receptor agonists.

Semple G, Boatman PD, Richman JG. Semple G, et al. Curr Opin Drug Discov Devel. 2007 Jul;10(4):452-9. Curr Opin Drug Discov Devel. 2007. PMID: 17659487 Review.

4

Clinically validated peptides as templates for de novo peptidomimetic drug design at G-protein-coupled receptors.

Jones RM, Boatman PD, Semple G, Shin YJ, Tamura SY. Jones RM, et al. Among authors: semple g. Curr Opin Pharmacol. 2003 Oct;3(5):530-43. doi: 10.1016/j.coph.2003.06.003. Curr Opin Pharmacol. 2003. PMID: 14559100 Review.

5

International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B).

Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP. Offermanns S, et al. Among authors: semple g. Pharmacol Rev. 2011 Jun;63(2):269-90. doi: 10.1124/pr.110.003301. Epub 2011 Mar 31. Pharmacol Rev. 2011. PMID: 21454438 Review.

6

(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.

Buzard DJ, Lopez L, Moody J, Kawasaki A, Schrader TO, Kasem M, Johnson B, Zhu X, Thoresen L, Kim SH, Gharbaoui T, Sengupta D, Calvano L, Krishnan A, Gao Y, Semple G, Edwards J, Barden J, Morgan M, Usmani K, Chen C, Sadeque A, Chen W, Christopher RJ, Thatte J, Fu L, Solomon M, Whelan K, Al-Shamma H, Gatlin J, Gaidarov I, Anthony T, Le M, Unett DJ, Stirn S, Blackburn A, Behan DP, Jones RM. Buzard DJ, et al. Among authors: semple g. ACS Med Chem Lett. 2014 Nov 25;5(12):1334-9. doi: 10.1021/ml500422m. eCollection 2014 Dec 11. ACS Med Chem Lett. 2014. PMID: 25516794 Free PMC article.

7

Discovery of a lead series of potent benzodiazepine 5-HT_2C receptor agonists with high selectivity in functional and binding assays.

Ren A, Zhu X, Feichtinger K, Lehman J, Kasem M, Schrader TO, Wong A, Dang H, Le M, Frazer J, Unett DJ, Grottick AJ, Whelan KT, Morgan ME, Sage CR, Semple G. Ren A, et al. Among authors: semple g. Bioorg Med Chem Lett. 2020 Mar 1;30(5):126929. doi: 10.1016/j.bmcl.2019.126929. Epub 2019 Dec 26. Bioorg Med Chem Lett. 2020. PMID: 31952960

8

ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety.

Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y. Chaki S, et al. Among authors: semple g. CNS Drug Rev. 2005 Winter;11(4):341-52. doi: 10.1111/j.1527-3458.2005.tb00052.x. CNS Drug Rev. 2005. PMID: 16614734 Free PMC article. Review.

9

Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series.

Han S, Narayanan S, Kim SH, Calderon I, Zhu X, Kawasaki A, Yue D, Lehmann J, Wong A, Buzard DJ, Semple G, Carroll C, Chu ZL, Al-Sharmma H, Shu HH, Tung SF, Unett DJ, Behan DP, Yoon WH, Morgan M, Usmani KA, Chen C, Sadeque A, Leonard JN, Jones RM. Han S, et al. Among authors: semple g. Bioorg Med Chem Lett. 2015 Aug 1;25(15):3034-8. doi: 10.1016/j.bmcl.2015.04.102. Epub 2015 May 23. Bioorg Med Chem Lett. 2015. PMID: 26048791

10

Embelin and its derivatives unravel the signaling, proinflammatory and antiatherogenic properties of GPR84 receptor.

Gaidarov I, Anthony T, Gatlin J, Chen X, Mills D, Solomon M, Han S, Semple G, Unett DJ. Gaidarov I, et al. Among authors: semple g. Pharmacol Res. 2018 May;131:185-198. doi: 10.1016/j.phrs.2018.02.021. Epub 2018 Feb 19. Pharmacol Res. 2018. PMID: 29471103

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