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2008 2
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60 results

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SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8+ T cells.
Wu Z, Huang H, Han Q, Hu Z, Teng XL, Ding R, Ye Y, Yu X, Zhao R, Wang Z, Zou Q. Wu Z, et al. J Clin Invest. 2022 Apr 1;132(7):e155224. doi: 10.1172/JCI155224. J Clin Invest. 2022. PMID: 35143421 Free PMC article.
SENP7-deficient CD8+ T cells exhibited decreased glycolysis and oxidative phosphorylation, resulting in attenuated proliferation in vitro and dampened antitumor functions in vivo. Mechanistically, CD8+ T cell-derived ROS triggered cytosolic SENP7-mediated PTEN deSUM
SENP7-deficient CD8+ T cells exhibited decreased glycolysis and oxidative phosphorylation, resulting in attenuated proliferation in v
SENP7 deSUMOylase-governed transcriptional program coordinates sarcomere assembly and is targeted in muscle atrophy.
Amrute-Nayak M, Gand LV, Khan B, Holler T, Kefalakes E, Kosanke M, Kraft T, Nayak A. Amrute-Nayak M, et al. Cell Rep. 2022 Nov 22;41(8):111702. doi: 10.1016/j.celrep.2022.111702. Cell Rep. 2022. PMID: 36417853 Free article.
We identify SENP7-dependent deSUMOylation of flightless-1 (Fli-I) as a signal for Fli-I association with scaffold attachment factor b1 (Safb1). ...We propose a SENP7-driven distinct transcription program as paramount for muscle cell function, which was found targete …
We identify SENP7-dependent deSUMOylation of flightless-1 (Fli-I) as a signal for Fli-I association with scaffold attachment factor b …
SENP7 knockdown inhibited pyroptosis and NF-kappaB/NLRP3 inflammasome pathway activation in Raw 264.7 cells.
Li X, Jiao F, Hong J, Yang F, Wang L, Gong Z. Li X, et al. Sci Rep. 2020 Oct 1;10(1):16265. doi: 10.1038/s41598-020-73400-w. Sci Rep. 2020. PMID: 33004957 Free PMC article.
We evaluated the effect of SENP7 knockdown on pyroptosis, NF-kappaB signaling pathway, and NLRP3 inflammasome in Raw 264.7 cells. ...The mechanism may be associated with the over SUMOylation of proteins induced by SENP7 knockdown....
We evaluated the effect of SENP7 knockdown on pyroptosis, NF-kappaB signaling pathway, and NLRP3 inflammasome in Raw 264.7 cells. ... …
Deregulation of SPOP in Cancer.
Zhang H, Jin X, Huang H. Zhang H, et al. Cancer Res. 2023 Feb 15;83(4):489-499. doi: 10.1158/0008-5472.CAN-22-2801. Cancer Res. 2023. PMID: 36512624 Review.
SPOP can mediate both degradable and nondegradable polyubiquitination of a number of substrates with diverse biological functions such as androgen receptor (AR), SRC-3, TRIM24, BRD4, PD-L1, 53BP1, GLP/G9a, c-Myc, SENP7, among others. Cancer-associated SPOP mutants often im …
SPOP can mediate both degradable and nondegradable polyubiquitination of a number of substrates with diverse biological functions such as an …
Structural Basis for the SUMO2 Isoform Specificity of SENP7.
Li Y, De Bolòs A, Amador V, Reverter D. Li Y, et al. J Mol Biol. 2022 Dec 30;434(24):167875. doi: 10.1016/j.jmb.2022.167875. Epub 2022 Nov 2. J Mol Biol. 2022. PMID: 36334780 Free article.
Here, we present the crystal structure of the catalytic domain of human SENP7 bound to SUMO2, revealing structural key elements for the SUMO2 isoform specificity of SENP7. ...Our data give insight into an evolutionary adaptation to restrict the deSUMOylating activit …
Here, we present the crystal structure of the catalytic domain of human SENP7 bound to SUMO2, revealing structural key elements for t …
DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells.
Suhail A, Rizvi ZA, Mujagond P, Ali SA, Gaur P, Singh M, Ahuja V, Awasthi A, Srikanth CV. Suhail A, et al. Cell Rep. 2019 Dec 10;29(11):3522-3538.e7. doi: 10.1016/j.celrep.2019.11.028. Cell Rep. 2019. PMID: 31825833 Free article.
In steady state, but not IBD, SENP7 expression was negatively regulated by a direct interaction and ubiquitination by SIAH2. ...Strong statistical correlations between upregulated SENP7 and high clinical disease indices were observed in IBD patients. ...
In steady state, but not IBD, SENP7 expression was negatively regulated by a direct interaction and ubiquitination by SIAH2. ...Stron …
Maternal SENP7 programs meiosis architecture and embryo survival in mouse.
Huang CJ, Wu D, Jiao XF, Khan FA, Xiong CL, Liu XM, Yang J, Yin TL, Huo LJ. Huang CJ, et al. Biochim Biophys Acta Mol Cell Res. 2017 Jul;1864(7):1195-1206. doi: 10.1016/j.bbamcr.2017.03.005. Epub 2017 Mar 16. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28315713 Free article.
Understanding the mechanisms underlying abnormal egg production and pregnancy loss is significant for human fertility. SENP7, a SUMO poly-chain editing enzyme, has been regarded as a mitotic regulator of heterochromatin integrity and DNA repair. Herein, we report the roles …
Understanding the mechanisms underlying abnormal egg production and pregnancy loss is significant for human fertility. SENP7, a SUMO …
Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation.
Pei J, Zou D, Li L, Kang L, Sun M, Li X, Chen Q, Chen D, Qu B, Gao X, Lin Z. Pei J, et al. J Biol Chem. 2024 Apr 25;300(6):107319. doi: 10.1016/j.jbc.2024.107319. Online ahead of print. J Biol Chem. 2024. PMID: 38677512 Free article.
Several members of the small ubiquitin-like modifier (SUMO)-specific protease (SENP) family have been reported as the regulators of lipid homeostasis. However, the function of Senp7 in lipid metabolism remains unclear. In this study, we generated both conventional and adip …
Several members of the small ubiquitin-like modifier (SUMO)-specific protease (SENP) family have been reported as the regulators of lipid ho …
SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing.
Cui Y, Yu H, Zheng X, Peng R, Wang Q, Zhou Y, Wang R, Wang J, Qu B, Shen N, Guo Q, Liu X, Wang C. Cui Y, et al. PLoS Pathog. 2017 Jan 17;13(1):e1006156. doi: 10.1371/journal.ppat.1006156. eCollection 2017 Jan. PLoS Pathog. 2017. PMID: 28095500 Free PMC article.
SENP7 reversed this inhibition via catalyzing the cGAS de-SUMOylation. ...SENP7-knockdown mice were more susceptible to herpes simplex virus 1 (HSV-1) infection. ...
SENP7 reversed this inhibition via catalyzing the cGAS de-SUMOylation. ...SENP7-knockdown mice were more susceptible to herpes
60 results