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Urotensin II activates the ferroptosis pathway through circ0004372/miR-124/SERTAD4 to promote the activation of vascular adventitial fibroblasts.
Hu YC, Han T, Fan YJ, Zhang CY, Zhang Y, Ma WD, Wang CX. Hu YC, et al. Gen Physiol Biophys. 2022 Sep;41(5):381-392. doi: 10.4149/gpb_2022027. Gen Physiol Biophys. 2022. PMID: 36222337
UII inhibited miR-124 expression through up-regulating circ0004372 expression, thereby promoting SERTAD4 expression. UII significantly promoted the generation of ROS, MDA and 4-HNE, reduced the activities of SOD, GST and GR, increased Fe2+ concentration and inhibited GPX4 …
UII inhibited miR-124 expression through up-regulating circ0004372 expression, thereby promoting SERTAD4 expression. UII significantl …
Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.
Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MPY, Haldar SM, Lin CY, McKinsey TA. Stratton MS, et al. Circ Res. 2019 Sep 13;125(7):662-677. doi: 10.1161/CIRCRESAHA.119.315125. Epub 2019 Aug 14. Circ Res. 2019. PMID: 31409188 Free PMC article.
Chromatin immunoprecipitation-sequencing revealed that BRD4 undergoes stimulus-dependent, genome-wide redistribution in cardiac fibroblasts, becoming enriched on a subset of enhancers and super-enhancers, and leading to RNA polymerase II activation and expression of downstream ta …
Chromatin immunoprecipitation-sequencing revealed that BRD4 undergoes stimulus-dependent, genome-wide redistribution in cardiac fibroblasts, …
Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength.
Al-Barghouthi BM, Mesner LD, Calabrese GM, Brooks D, Tommasini SM, Bouxsein ML, Horowitz MC, Rosen CJ, Nguyen K, Haddox S, Farber EA, Onengut-Gumuscu S, Pomp D, Farber CR. Al-Barghouthi BM, et al. Nat Commun. 2021 Jun 7;12(1):3408. doi: 10.1038/s41467-021-23649-0. Nat Commun. 2021. PMID: 34099702 Free PMC article.
We apply a network approach to cortical bone RNA-seq data to discover 66 genes likely to be causal for human BMD GWAS associations, including the genes SERTAD4 and GLT8D2. We also perform GWAS in the DO for a wide-range of bone traits and identify Qsox1 as a gene influenci …
We apply a network approach to cortical bone RNA-seq data to discover 66 genes likely to be causal for human BMD GWAS associations, includin …
Identification of novel susceptibility loci for non-syndromic cleft lip with or without cleft palate.
Ma L, Lou S, Miao Z, Yao S, Yu X, Kan S, Zhu G, Yang F, Zhang C, Zhang W, Wang M, Wang L, Pan Y. Ma L, et al. J Cell Mol Med. 2020 Dec;24(23):13669-13678. doi: 10.1111/jcmm.15878. Epub 2020 Oct 27. J Cell Mol Med. 2020. PMID: 33108691 Free PMC article.
Here, we performed an in-depth analysis of our previously published Chinese GWAS cohort study with replication in an extra dbGaP case-parent trios and another in-house Nanjing cohort, and finally identified five novel significant association signals (rs11119445: 3' of SERTAD4
Here, we performed an in-depth analysis of our previously published Chinese GWAS cohort study with replication in an extra dbGaP case-parent …
Neuroprotective effects of acteoside in a glaucoma mouse model by targeting Serta domain-containing protein 4.
Hao HJ, Li YH, Yu B, Liu X, Zhang Y, Xing XL. Hao HJ, et al. Int J Ophthalmol. 2024 Apr 18;17(4):625-637. doi: 10.18240/ijo.2024.04.04. eCollection 2024. Int J Ophthalmol. 2024. PMID: 38638260 Free PMC article.
RESULTS: Proteomics analysis suggested that Sertad4 was the most significantly differentially expressed protein. ...CONCLUSION: Sertad4 is differentially expressed in DBA/2J mice. Acteoside can protect RGCs from damage, possibly through the downregulation of Sert
RESULTS: Proteomics analysis suggested that Sertad4 was the most significantly differentially expressed protein. ...CONCLUSION: Se
The Interferon Gamma-Related Long Noncoding RNA Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Colon Adenocarcinoma.
Liu C, Liu D, Wang F, Xie J, Liu Y, Wang H, Rong J, Xie J, Wang J, Zeng R, Xie Y. Liu C, et al. Front Oncol. 2022 Jun 7;12:876660. doi: 10.3389/fonc.2022.876660. eCollection 2022. Front Oncol. 2022. PMID: 35747790 Free PMC article.
Thirteen lncRNAs (AC025165.8, AC091633.3, FENDRR, LINC00882, LINC01828, LINC01829, MYOSLID, RP11-154H23.4, RP11-20J15.3, RP11-324L17.1, RP11-342A23.2, RP11-805I24.3, SERTAD4-AS1) were identified to construct an IFN-gamma-related lncRNA prognostic signature in TCGA training …
Thirteen lncRNAs (AC025165.8, AC091633.3, FENDRR, LINC00882, LINC01828, LINC01829, MYOSLID, RP11-154H23.4, RP11-20J15.3, RP11-324L17.1, RP11 …
I-mfa domain proteins specifically interact with SERTA domain proteins and repress their transactivating functions.
Kusano S, Shiimura Y, Eizuru Y. Kusano S, et al. Biochimie. 2011 Sep;93(9):1555-64. doi: 10.1016/j.biochi.2011.05.016. Epub 2011 May 31. Biochimie. 2011. PMID: 21664411
In addition, I-mfa also specifically interacts with other SERTA domain-containing proteins, including SEI-2, SEI-3, SERTAD3 and SERTAD4, through its I-mfa domain in vivo. This interaction also affects the intracellular localization of I-mfa and represses the intrinsic tran …
In addition, I-mfa also specifically interacts with other SERTA domain-containing proteins, including SEI-2, SEI-3, SERTAD3 and SERTAD4
The impact of PSRC1 overexpression on gene and transcript expression profiling in the livers of ApoE-/- mice fed a high-fat diet.
Wei M, Li P, Guo K. Wei M, et al. Mol Cell Biochem. 2020 Feb;465(1-2):125-139. doi: 10.1007/s11010-019-03673-x. Epub 2019 Dec 14. Mol Cell Biochem. 2020. PMID: 31838625
A total of 1892 significant DEGs were identified: 1431 were upregulated (e.g., Cyp2a4, Obp2a, and Sertad4), and 461 were downregulated (e.g., Moxd1, Egr1, and Elovl3). ...
A total of 1892 significant DEGs were identified: 1431 were upregulated (e.g., Cyp2a4, Obp2a, and Sertad4), and 461 were downregulate …
Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP).
Bennetts JS, Fowles LF, Berkman JL, van Bueren KL, Richman JM, Simpson F, Wicking C. Bennetts JS, et al. Gene. 2006 Jun 7;374:153-65. doi: 10.1016/j.gene.2006.01.027. Epub 2006 Mar 20. Gene. 2006. PMID: 16546331
Using in silico database mining we have extended the number of evolutionarily conserved orthologues of known SERTA domain proteins and identified an uncharacterised member of the SERTA domain family, SERTAD4, with orthologues to date in human, mouse, rat, dog, cow, Tetraod …
Using in silico database mining we have extended the number of evolutionarily conserved orthologues of known SERTA domain proteins and ident …
The transcriptional response of mouse spleen B cells to IL-4: Comparison to the response of human peripheral blood B cells.
Ruiz-Lafuente N, Muro M, Minguela A, Parrado A. Ruiz-Lafuente N, et al. Biochem Biophys Rep. 2018 Oct 6;16:56-61. doi: 10.1016/j.bbrep.2018.09.007. eCollection 2018 Dec. Biochem Biophys Rep. 2018. PMID: 30302405 Free PMC article.
We detected an mSBC-specific response (including novel genes, e.g., Sertad4, Lifr, Pmepa1, Epcam, Tbxas1; and common genes, e.g., Usp2, Cst7, Grtp1, and Casp6), an hPBBC-specific response (e.g., CCL17, MTCL1, GCSAM, HOMER2, IL2RA), and a common mSBC/hPBBC response (e.g., C …
We detected an mSBC-specific response (including novel genes, e.g., Sertad4, Lifr, Pmepa1, Epcam, Tbxas1; and common genes, e.g., Usp …