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Page 1
SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism.
Kory N, Wyant GA, Prakash G, Uit de Bos J, Bottanelli F, Pacold ME, Chan SH, Lewis CA, Wang T, Keys HR, Guo YE, Sabatini DM. Kory N, et al. Science. 2018 Nov 16;362(6416):eaat9528. doi: 10.1126/science.aat9528. Science. 2018. PMID: 30442778 Free PMC article.
Cells lacking SFXN1 and one of its four homologs, SFXN3, have more severe defects, including being auxotrophic for glycine. Purified SFXN1 transports serine in vitro. ...
Cells lacking SFXN1 and one of its four homologs, SFXN3, have more severe defects, including being auxotrophic for glycine. Purified …
SFXN3 is a Prognostic Marker and Promotes the Growth of Acute Myeloid Leukemia.
Jin F, He L, Wang J, Zhang Y, Yang M. Jin F, et al. Cell Biochem Biophys. 2024 Sep;82(3):2195-2204. doi: 10.1007/s12013-024-01326-5. Epub 2024 Jun 14. Cell Biochem Biophys. 2024. PMID: 38877336 Free PMC article.
SFXN3 is expressed at higher levels in AML, and high SFXN3 level is associated with decreased overall survival rate (OSR) in AML. ...Finally, SFXN3 may related to the immunosuppressive state of AML. Increased SFXN3 expression is detected in AML, which …
SFXN3 is expressed at higher levels in AML, and high SFXN3 level is associated with decreased overall survival rate (OSR) in A …
SFXN3 is Associated with Poor Clinical Outcomes and Sensitivity to the Hypomethylating Therapy in Non-M3 Acute Myeloid Leukemia Patients.
Dong Y, Jin F, Wang J, Li Q, Huang Z, Xia L, Yang M. Dong Y, et al. Curr Gene Ther. 2023;23(5):410-418. doi: 10.2174/1566523223666230724121515. Curr Gene Ther. 2023. PMID: 37491851 Free PMC article.
RESULTS: Through the TCGA and GEPIA databases, we found that SFXN3 was enriched in AML patients, predicting shorter survival. Furthermore, we confirmed that SFXN3 was primarily overexpressed in AML patients, especially non-M3 patients, and that high SFXN3 in …
RESULTS: Through the TCGA and GEPIA databases, we found that SFXN3 was enriched in AML patients, predicting shorter survival. Further …
The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo.
Ledahawsky LM, Terzenidou ME, Edwards R, Kline RA, Graham LC, Eaton SL, van der Hoorn D, Chaytow H, Huang YT, Groen EJN, Motyl AAL, Lamont DJ, Tokatlidis K, Wishart TM, Gillingwater TH. Ledahawsky LM, et al. FEBS J. 2022 Jul;289(13):3894-3914. doi: 10.1111/febs.16377. Epub 2022 Feb 6. FEBS J. 2022. PMID: 35092170 Free PMC article.
We first show that SFXN3 uses the carrier import pathway to insert into the inner mitochondrial membrane. ...In contrast, the loss of SFXN3 was insufficient to trigger neurodegeneration in mice, indicating an anti- rather than pro-neurodegeneration role for SFXN3 …
We first show that SFXN3 uses the carrier import pathway to insert into the inner mitochondrial membrane. ...In contrast, the loss of …
Non-coding RNA-mediated high expression of SFXN3 as a prognostic biomarker associated with paclitaxel resistance and immunosuppressive microenvironment in head and neck cancer.
Chen K, Gong S, Fang X, Li Q, Ye M, Li J, Huang S, Zhao Y, Liu N, Li Y, Ma J. Chen K, et al. Front Immunol. 2022 Sep 8;13:920136. doi: 10.3389/fimmu.2022.920136. eCollection 2022. Front Immunol. 2022. PMID: 36159813 Free PMC article.
However, the specific role of SFXN3 in HNSC remains unknown. In this study, we performed expression and survival analysis for SFXN3 in pan-cancer using data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) and found that SFXN3 served …
However, the specific role of SFXN3 in HNSC remains unknown. In this study, we performed expression and survival analysis for SFXN …
Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice.
Chen B, Aredo B, Ding Y, Zhong X, Zhu Y, Zhao CX, Kumar A, Xing C, Gautron L, Lyon S, Russell J, Li X, Tang M, Anderton P, Ludwig S, Moresco EMY, Beutler B, Ufret-Vincenty RL. Chen B, et al. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12931-12942. doi: 10.1073/pnas.1921224117. Epub 2020 May 26. Proc Natl Acad Sci U S A. 2020. PMID: 32457148 Free PMC article.
Furthermore, pathway analysis suggests that Sfxn3 may be associated with synaptic homeostasis. Importantly, electron microscopy analysis showed disruption of synapses and synaptic ribbons in the outer plexiform layer of Sfxn3(-/-) mice. Our work describes a previous …
Furthermore, pathway analysis suggests that Sfxn3 may be associated with synaptic homeostasis. Importantly, electron microscopy analy …
Sideroflexin 3 is a Mitochondrial Protein Enriched in Neurons.
Rivell A, Petralia RS, Wang YX, Mattson MP, Yao PJ. Rivell A, et al. Neuromolecular Med. 2019 Sep;21(3):314-321. doi: 10.1007/s12017-019-08553-7. Epub 2019 Jun 8. Neuromolecular Med. 2019. PMID: 31177362 Free PMC article.
Similarly, in cultured hippocampal neurons, Sfxn3 protein level is low in young neurons but increases as neurons mature. Sfxn3 protein level is much higher in neurons than in astrocytes. Within neurons, Sfxn3 localizes to mitochondria in all major neuronal co …
Similarly, in cultured hippocampal neurons, Sfxn3 protein level is low in young neurons but increases as neurons mature. Sfxn3 …
Roles of CTPL/Sfxn3 and Sfxn family members in pancreatic islet.
Yoshikumi Y, Mashima H, Ueda N, Ohno H, Suzuki J, Tanaka S, Hayashi M, Sekine N, Ohnishi H, Yasuda H, Iiri T, Omata M, Fujita T, Kojima I. Yoshikumi Y, et al. J Cell Biochem. 2005 Aug 15;95(6):1157-68. doi: 10.1002/jcb.20481. J Cell Biochem. 2005. PMID: 15864810
Recently sideroflexin 1 (Sfxn1) was shown to be a susceptible gene of flexed-tail (f/f) mice, and CTPL has turned out to be a rat orthologous protein of Sfxn3, a member of sideroflexin family. CTPL/Sfxn3 was targeted to mitochondrial membrane like Sfxn1. The express …
Recently sideroflexin 1 (Sfxn1) was shown to be a susceptible gene of flexed-tail (f/f) mice, and CTPL has turned out to be a rat orthologou …
SFXN3 Serves as a Predictive Biomarker for Cisplatin Response and Survival in Head and Neck Squamous Cell Carcinoma.
Jeong EJ, Kim YS, Lee Y, Ryu JS, Choi YH, Kim E. Jeong EJ, et al. Oncol Res. 2026 May 21;34(6):22. doi: 10.32604/or.2026.078376. eCollection 2026. Oncol Res. 2026. PMID: 42232609 Free PMC article.
This study aims to delineate the clinical and functional significance of SFXN3 in HNSCC. Methods: We interrogated SFXN3 expression patterns, patient survival outcomes, and immune cell infiltration characteristics utilizing multiple independent repositories, includin …
This study aims to delineate the clinical and functional significance of SFXN3 in HNSCC. Methods: We interrogated SFXN3 expres …
Sideroflexins enable mitochondrial transport of polar neutral amino acids.
Block S, Chi F, Rosen PC, Pineda SS, Darnell AM, Abbott KL, Pena IA, Heiman M, Yilmaz ÖH, Kory N, Vander Heiden MG. Block S, et al. bioRxiv [Preprint]. 2025 Jul 2:2025.06.18.660357. doi: 10.1101/2025.06.18.660357. bioRxiv. 2025. PMID: 40631095 Free PMC article. Preprint.
Furthermore, the SFXN1 paralogues SFXN2 and SFXN3 partially complement loss of SFXN1 to enable glycine transport, while SFXN2 and SFXN5 partially complement loss of SFXN1 to enable GABA transport. ...
Furthermore, the SFXN1 paralogues SFXN2 and SFXN3 partially complement loss of SFXN1 to enable glycine transport, while SFXN2 and SFX …
26 results