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SGIP1 in axons prevents internalization of desensitized CB1R and modifies its function.
Durydivka O, Mackie K, Blahos J. Durydivka O, et al. Front Neurosci. 2023 Jul 20;17:1213094. doi: 10.3389/fnins.2023.1213094. eCollection 2023. Front Neurosci. 2023. PMID: 37547151 Free PMC article. Review.
This review then focuses on a potential candidate for maintaining axonal CB1R at the cell surface, Src homology 3-domain growth factor receptor-bound 2-like endophilin interacting protein 1 (SGIP1). SGIP1 may contribute to the polarized distribution of CB1R and modi …
This review then focuses on a potential candidate for maintaining axonal CB1R at the cell surface, Src homology 3-domain growth factor recep …
A candidate loss-of-function variant in SGIP1 causes synaptic dysfunction and recessive parkinsonism.
Decet M, Scott P, Kuenen S, Meftah D, Swerts J, Calatayud C, Gallego SF, Kaempf N, Nachman E, Praschberger R, Schoovaerts N, Tang CC, Eidelberg D, Al Adawi S, Al Asmi A, Nandhagopal R, Verstreken P. Decet M, et al. Cell Rep Med. 2024 Oct 15;5(10):101749. doi: 10.1016/j.xcrm.2024.101749. Epub 2024 Sep 26. Cell Rep Med. 2024. PMID: 39332416 Free PMC article.
We have identified a candidate causative mutation in synaptic "SH3GL2 Interacting Protein 1" (SGIP1), linked to early-onset parkinsonism in a consanguineous Arab family. Additionally, affected siblings display intellectual, cognitive, and behavioral dysfunction. Metabolic …
We have identified a candidate causative mutation in synaptic "SH3GL2 Interacting Protein 1" (SGIP1), linked to early-onset parkinson …
SGIP1 binding to the alpha-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression.
Fletcher-Jones A, Spackman E, Craig TJ, Nakamura Y, Wilkinson KA, Henley JM. Fletcher-Jones A, et al. J Cell Sci. 2024 Jun 1;137(11):jcs261551. doi: 10.1242/jcs.261551. Epub 2024 Jun 12. J Cell Sci. 2024. PMID: 38864427 Free PMC article.
Conversely, SGIP1 knockdown reduces axonal surface expression of CB1R but does not affect CB1RdeltaH9. Furthermore, SGIP1 knockdown diminishes CB1R-mediated inhibition of presynaptic Ca2+ influx in response to neuronal activity. ...
Conversely, SGIP1 knockdown reduces axonal surface expression of CB1R but does not affect CB1RdeltaH9. Furthermore, SGIP1 knoc …
Multiple Sgip1 splice variants inhibit cannabinoid receptor 1 internalization.
Durydivka O, Gazdarica M, Vecerkova K, Radenkovic S, Blahos J. Durydivka O, et al. Gene. 2024 Jan 20;892:147851. doi: 10.1016/j.gene.2023.147851. Epub 2023 Sep 30. Gene. 2024. PMID: 37783296 Free article.
Several research groups have studied the physiological importance of Sgip1, and four Sgip1 protein isoforms have been described to date, while the NCBI Gene database predicts the expression of 20 splice variants from the Sgip1 gene in mice. ...None of the iso …
Several research groups have studied the physiological importance of Sgip1, and four Sgip1 protein isoforms have been describe …
SGIP1 modulates kinetics and interactions of the cannabinoid receptor 1 and G protein-coupled receptor kinase 3 signalosome.
Gazdarica M, Noda J, Durydivka O, Novosadova V, Mackie K, Pin JP, Prezeau L, Blahos J. Gazdarica M, et al. J Neurochem. 2022 Mar;160(6):625-642. doi: 10.1111/jnc.15569. Epub 2022 Jan 11. J Neurochem. 2022. PMID: 34970999 Free PMC article.
Furthermore, CB1R signaling is regulated by the protein Src homology 3-domain growth factor receptor-bound 2-like (SGIP1) that hinders receptor internalization, while enhancing CB1R association with beta-arrestin. ...Altogether, our data suggest that the CB1R signalosome c …
Furthermore, CB1R signaling is regulated by the protein Src homology 3-domain growth factor receptor-bound 2-like (SGIP1) that hinder …
SGIP1 dimerizes via intermolecular disulfide bond in muHD domain during cellular endocytosis.
Zhang Y, Feng Y, Xin Y, Liu X. Zhang Y, et al. Biochem Biophys Res Commun. 2018 Oct 20;505(1):99-105. doi: 10.1016/j.bbrc.2018.09.075. Epub 2018 Sep 18. Biochem Biophys Res Commun. 2018. PMID: 30236986
Along with its homologs FCHo1 and FCHo2, SGIP1 plays an important role in clathrin-mediated endocytosis. The highly conserved C-terminal muHD domains in these proteins are the critical regions interacting with adapter molecules such as Eps15. The crystal structure of muHD …
Along with its homologs FCHo1 and FCHo2, SGIP1 plays an important role in clathrin-mediated endocytosis. The highly conserved C-termi …
SGIP1 Deletion in Mice Attenuates Mechanical Hypersensitivity Elicited by Inflammation.
Durydivka O, Kuchar M, Blahos J. Durydivka O, et al. Cannabis Cannabinoid Res. 2025 Apr;10(2):247-257. doi: 10.1089/can.2024.0020. Epub 2024 Jul 9. Cannabis Cannabinoid Res. 2025. PMID: 38979622
Following THC or WIN treatment in male mice, SGIP1 knock-out males exhibited PWT lower than wild-type males. THC treatment in SGIP1 knock-out females resulted in PWT higher than after THC treatment of wild-type females. However, SGIP1 knock-out and wild-type …
Following THC or WIN treatment in male mice, SGIP1 knock-out males exhibited PWT lower than wild-type males. THC treatment in SGIP …
SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB(1) receptors.
Dvorakova M, Kubik-Zahorodna A, Straiker A, Sedlacek R, Hajkova A, Mackie K, Blahos J. Dvorakova M, et al. Br J Pharmacol. 2021 Apr;178(7):1588-1604. doi: 10.1111/bph.15383. Epub 2021 Feb 27. Br J Pharmacol. 2021. PMID: 33491188 Free PMC article.
EXPERIMENTAL APPROACH: Using a battery of behavioural tests, we investigated the consequences of SGIP1 deletion in tasks regulated by the ECS in SGIP1 constitutive knockout (SGIP1(-/-) ) mice. ...SGIP1 deletion also reduces acute nociception, and SG …
EXPERIMENTAL APPROACH: Using a battery of behavioural tests, we investigated the consequences of SGIP1 deletion in tasks regulated by …
SGIP1alpha, but Not SGIP1, is an Ortholog of FCHo Proteins and Functions as an Endocytic Regulator.
Lee SE, Cho E, Jeong S, Song Y, Kang S, Chang S. Lee SE, et al. Front Cell Dev Biol. 2021 Dec 24;9:801420. doi: 10.3389/fcell.2021.801420. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 35004694 Free PMC article.
Thus, our results indicate that SGIP1alpha, but not SGIP1, is the functional ortholog of FCHos, and SGIP1 and SGIP1alpha are not functionally redundant. These findings suggest that caution should be taken in interpreting the role of SGIP1 in endocytosis....
Thus, our results indicate that SGIP1alpha, but not SGIP1, is the functional ortholog of FCHos, and SGIP1 and SGIP1alpha are n …
Plasma SGIP1 methylation in diagnosis and prognosis prediction in hepatocellular carcinoma.
Xie GF, Xu YX, Xu F, Sun LY, Ye ZL, Ma JJ, Wang HY, Shao JY. Xie GF, et al. Neoplasma. 2021 Jan;68(1):62-70. doi: 10.4149/neo_2020_200623N657. Epub 2020 Oct 30. Neoplasma. 2021. PMID: 33118832
This study aimed to investigate the diagnostic and prognostic value of plasma SGIP1 methylation in HCC. The study included a total of 269 subjects, of which 129 were with HCC, 45 with liver cirrhosis (LC), 45 with chronic hepatitis B (CHB), and 50 were healthy controls (HC …
This study aimed to investigate the diagnostic and prognostic value of plasma SGIP1 methylation in HCC. The study included a total of …
47 results