The G-Protein-Coupled Estrogen Receptor Agonist Prevents Cardiac Lipid Accumulation by Stimulating Cardiac Peroxisome Proliferator-Activated Receptor α: A Preclinical Study in Ovariectomized-Diabetic Rat Model.
Jafarynezhad F, Shahbazian M, Farhadi Z, Yadeghari M, Rezvani ME, Safari F, Azizian H.
Jafarynezhad F, et al.
Int J Endocrinol Metab. 2022 Jul 12;20(3):e123560. doi: 10.5812/ijem-123560. eCollection 2022 Jul.
Int J Endocrinol Metab. 2022.
PMID: 36407026
Free PMC article.
METHODS: Female Wistar rats were divided into 5 groups (n = 7 in each group): Sham-control (Sh-Ctl), T2DM, ovariectomized-T2DM (OVX-T2DM), OVX-T2DM-G1 (GPER-agonist), and OVX-T2DM-vehicle (OVX-T2DM-Veh). ...Then, the levels of free fatty acids (FFAs), CD36, peroxisome prol …
METHODS: Female Wistar rats were divided into 5 groups (n = 7 in each group): Sham-control (Sh-Ctl), T2DM, ovariectomized-T2DM (OVX-T …