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72 results

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SH3BP5-AS1/IGF2BP2/VDAC2 Axis Promotes the Apoptosis and Ferroptosis of Bladder Cancer Cells.
Shao Y, Chan Y, Zhao R. Shao Y, et al. Bladder Cancer. 2023 Mar 31;9(1):29-40. doi: 10.3233/BLC-211629. eCollection 2023. Bladder Cancer. 2023. PMID: 38994477 Free PMC article.
SH3BP5-AS1 was also found to facilitate the ferroptosis of BC cells. Additionally, SH3BP5-AS1 was confirmed to recruit IGF2BP2 to regulate VDAC2 expression in the m(6)A-dependent manner. ...Moreover, it was indicated from rescue assays that SH3BP5-AS1 could m …
SH3BP5-AS1 was also found to facilitate the ferroptosis of BC cells. Additionally, SH3BP5-AS1 was confirmed to recruit IGF2BP2 …
LncRNA SH3BP5-AS1 promotes hepatocellular carcinoma progression by sponging miR-6838-5p and activation of PTPN4.
Zhao X, Zhu X, Xiao C, Hu Z. Zhao X, et al. Aging (Albany NY). 2024 May 16;16(10):8511-8523. doi: 10.18632/aging.205811. Epub 2024 May 16. Aging (Albany NY). 2024. PMID: 38761175 Free PMC article.
In this work, we sought to determine LncRNA SH3BP5-AS1's function and mechanism in the emergence of HCC. RESULTS: First, we discovered that the advanced tumor stage was strongly correlated with high levels of LncRNA SH3BP5-AS1 expression in HCC. MiR-6838-5p expressi …
In this work, we sought to determine LncRNA SH3BP5-AS1's function and mechanism in the emergence of HCC. RESULTS: First, we discovere …
METTL3 suppresses invasion of lung cancer via SH3BP5 m6A modification.
Zhang B, Qian R, Li X. Zhang B, et al. Arch Biochem Biophys. 2024 Feb;752:109876. doi: 10.1016/j.abb.2023.109876. Epub 2023 Dec 21. Arch Biochem Biophys. 2024. PMID: 38141906
Furthermore, SH3 domain binding protein 5 (SH3BP5) was identified as a downstream target of METTL3. Overexpression of SH3BP5 suppressed the invasive capacity of lung cancer cells, and this regulation was m6A-dependent. ...We demonstrated that METTL3 regulates the mR …
Furthermore, SH3 domain binding protein 5 (SH3BP5) was identified as a downstream target of METTL3. Overexpression of SH3BP5 s …
N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway.
Lin C, Wang Y, Dong Y, Lai S, Wang L, Weng S, Zhang X. Lin C, et al. Biol Direct. 2022 Nov 17;17(1):33. doi: 10.1186/s13062-022-00347-5. Biol Direct. 2022. PMID: 36397058 Free PMC article.
SH3BP5-AS1 stability was regulated by ALKBH5/IGF2BP1-mediated m6A modification. Loss of SH3BP5-AS1 reduced PC cell migration and invasion and enhanced the sensitivity of PC to GEM, as confirmed by gain- and loss-of-function assays in vitro and in vivo. ...SH3BP5 …
SH3BP5-AS1 stability was regulated by ALKBH5/IGF2BP1-mediated m6A modification. Loss of SH3BP5-AS1 reduced PC cell migration a …
Novel blood-based hypomethylation of SH3BP5 is associated with very early-stage lung adenocarcinoma.
Qiao R, Zhong R, Liu C, Di F, Zhang Z, Wang L, Xu T, Wang Y, Dai L, Gu W, Han B, Yang R. Qiao R, et al. Genes Genomics. 2022 Apr;44(4):445-453. doi: 10.1007/s13258-021-01190-0. Epub 2021 Nov 16. Genes Genomics. 2022. PMID: 34783986
OBJECTIVE: We applied a candidate approach and assess the association between blood-based SH3BP5 methylation and the risk of lung adenocarcinoma (LUAD) in a case-control cohort. ...Moreover, the lower quartile of SH3BP5_CpG_4 methylation was correlated with increase …
OBJECTIVE: We applied a candidate approach and assess the association between blood-based SH3BP5 methylation and the risk of lung ade …
Elevated SH3BP5 Correlates with Poor Outcome and Contributes to the Growth of Acute Myeloid Leukemia Cells.
Li M, Hao S, Li C, Xiao H, Sun L, Yu Z, Zhang N, Xiong Y, Zhao D, Yin Y. Li M, et al. Biomolecules. 2019 Sep 19;9(9):505. doi: 10.3390/biom9090505. Biomolecules. 2019. PMID: 31546831 Free PMC article.
Herein, we report that the elevated expression of SH3 domain-binding protein 5 (SH3BP5) significantly correlates with poor outcomes of AML patients. To test whether SH3BP5 contributes to the growth and survival of AML cells, we use the shRNA-encoding lentivirus syst …
Herein, we report that the elevated expression of SH3 domain-binding protein 5 (SH3BP5) significantly correlates with poor outcomes o …
REI/SH3BP5 protein family: New GEFs for Rab11.
Sato K, Sakaguchi A, Sato M. Sato K, et al. Cell Cycle. 2016;15(6):767-9. doi: 10.1080/15384101.2015.1137710. Cell Cycle. 2016. PMID: 26745340 Free PMC article. No abstract available.
Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure.
Torres S, Baulies A, Insausti-Urkia N, Alarcón-Vila C, Fucho R, Solsona-Vilarrasa E, Núñez S, Robles D, Ribas V, Wakefield L, Grompe M, Lucena MI, Andrade RJ, Win S, Aung TA, Kaplowitz N, García-Ruiz C, Fernández-Checa JC. Torres S, et al. Gastroenterology. 2019 Aug;157(2):552-568. doi: 10.1053/j.gastro.2019.04.023. Epub 2019 Apr 25. Gastroenterology. 2019. PMID: 31029706 Free article.
BACKGROUND & AIMS: Acetaminophen (APAP) overdose is a major cause of acute liver failure (ALF). Mitochondrial SH3BP5 (also called SAB) and phosphorylation of c-Jun N-terminal kinase (JNK) mediate the hepatotoxic effects of APAP. ...CONCLUSIONS: In studies of mice, we f …
BACKGROUND & AIMS: Acetaminophen (APAP) overdose is a major cause of acute liver failure (ALF). Mitochondrial SH3BP5 (also called …
Structural basis of guanine nucleotide exchange for Rab11 by SH3BP5.
Goto-Ito S, Morooka N, Yamagata A, Sato Y, Sato K, Fukai S. Goto-Ito S, et al. Life Sci Alliance. 2019 Mar 14;2(2):e201900297. doi: 10.26508/lsa.201900297. Print 2019 Apr. Life Sci Alliance. 2019. PMID: 30872413 Free PMC article.
Here, we report the crystal structures of the SH3BP5 GEF domain alone and its complex with Rab11a. SH3BP5 exhibits a V-shaped structure comprising two coiled coils. ...SH3BP5 interacts with the N-terminal region, switch I, interswitch, and switch II of Rab11a …
Here, we report the crystal structures of the SH3BP5 GEF domain alone and its complex with Rab11a. SH3BP5 exhibits a V-shaped …
72 results