Shepard RL[au] - Search Results

Year	Number of Results
1987	1
1989	1
1994	2
1996	1
1997	1
1998	1
1999	3
2001	1
2002	4
2003	2
2004	1
2005	2
2012	1
2013	3
2015	1
2021	0

1

Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells.

Pratt SE, Durland-Busbice S, Shepard RL, Heinz-Taheny K, Iversen PW, Dantzig AH. Pratt SE, et al. Among authors: shepard rl. Clin Cancer Res. 2013 Mar 1;19(5):1159-68. doi: 10.1158/1078-0432.CCR-12-1184. Epub 2013 Jan 16. Clin Cancer Res. 2013. PMID: 23325581 Free article.

2

Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, Leads to Altered Carbohydrate Metabolism in Cancer Cells.

Tan B, Dong S, Shepard RL, Kays L, Roth KD, Geeganage S, Kuo MS, Zhao G. Tan B, et al. Among authors: shepard rl. J Biol Chem. 2015 Jun 19;290(25):15812-15824. doi: 10.1074/jbc.M114.632141. Epub 2015 May 5. J Biol Chem. 2015. PMID: 25944913 Free PMC article.

3

Efficacy of low-dose oral metronomic dosing of the prodrug of gemcitabine, LY2334737, in human tumor xenografts.

Pratt SE, Durland-Busbice S, Shepard RL, Donoho GP, Starling JJ, Wickremsinhe ER, Perkins EJ, Dantzig AH. Pratt SE, et al. Among authors: shepard rl. Mol Cancer Ther. 2013 Apr;12(4):481-90. doi: 10.1158/1535-7163.MCT-12-0654. Epub 2013 Jan 31. Mol Cancer Ther. 2013. PMID: 23371859 Free article.

4

Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.

Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA. Ekins S, et al. Among authors: shepard rl. Mol Pharmacol. 2002 May;61(5):964-73. doi: 10.1124/mol.61.5.964. Mol Pharmacol. 2002. PMID: 11961113

5

Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications.

Tan B, Young DA, Lu ZH, Wang T, Meier TI, Shepard RL, Roth K, Zhai Y, Huss K, Kuo MS, Gillig J, Parthasarathy S, Burkholder TP, Smith MC, Geeganage S, Zhao G. Tan B, et al. Among authors: shepard rl. J Biol Chem. 2013 Feb 1;288(5):3500-11. doi: 10.1074/jbc.M112.394510. Epub 2012 Dec 13. J Biol Chem. 2013. PMID: 23239881 Free PMC article.

6

Pharmacological characterization of LY335979: a potent cyclopropyldibenzosuberane modulator of P-glycoprotein.

Starling JJ, Shepard RL, Cao J, Law KL, Norman BH, Kroin JS, Ehlhardt WJ, Baughman TM, Winter MA, Bell MG, Shih C, Gruber J, Elmquist WF, Dantzig AH. Starling JJ, et al. Among authors: shepard rl. Adv Enzyme Regul. 1997;37:335-47. doi: 10.1016/s0065-2571(96)00021-0. Adv Enzyme Regul. 1997. PMID: 9381979

7

Modulation of P-glycoprotein but not MRP1- or BCRP-mediated drug resistance by LY335979.

Shepard RL, Cao J, Starling JJ, Dantzig AH. Shepard RL, et al. Int J Cancer. 2003 Jan 1;103(1):121-5. doi: 10.1002/ijc.10792. Int J Cancer. 2003. PMID: 12455064 Free article.

8

The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.

Pratt S, Shepard RL, Kandasamy RA, Johnston PA, Perry W 3rd, Dantzig AH. Pratt S, et al. Among authors: shepard rl. Mol Cancer Ther. 2005 May;4(5):855-63. doi: 10.1158/1535-7163.MCT-04-0291. Mol Cancer Ther. 2005. PMID: 15897250 Free article.

9

Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates.

Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA. Ekins S, et al. Among authors: shepard rl. Mol Pharmacol. 2002 May;61(5):974-81. doi: 10.1124/mol.61.5.974. Mol Pharmacol. 2002. PMID: 11961114

10

Association of intestinal peptide transport with a protein related to the cadherin superfamily.

Dantzig AH, Hoskins JA, Tabas LB, Bright S, Shepard RL, Jenkins IL, Duckworth DC, Sportsman JR, Mackensen D, Rosteck PR Jr, et al. Dantzig AH, et al. Among authors: shepard rl. Science. 1994 Apr 15;264(5157):430-3. doi: 10.1126/science.8153632. Science. 1994. PMID: 8153632

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