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Page 1
Restriction of Flaviviruses by an Interferon-Stimulated Gene SHFL/C19orf66.
Suzuki Y, Murakawa T. Suzuki Y, et al. Int J Mol Sci. 2022 Oct 20;23(20):12619. doi: 10.3390/ijms232012619. Int J Mol Sci. 2022. PMID: 36293480 Free PMC article. Review.
Interestingly, SHFL functions as a broad-spectrum antiviral factor exhibiting suppressive activity against various types of RNA and DNA viruses. In this review, we summarize the current understanding of the molecular mechanisms by which SHFL inhibits flavivirus infe …
Interestingly, SHFL functions as a broad-spectrum antiviral factor exhibiting suppressive activity against various types of RNA and D …
SHFL inhibits enterovirus A71 infection by triggering degradation of viral 3D(pol) protein via the ubiquitin-proteasome pathway.
Tan C, Qin X, Tan Y, Dong X, Chen D, Liang L, Li J, Niu R, Cao K, He Z, Wei G, Huang M, Zhu X. Tan C, et al. J Med Virol. 2023 Aug;95(8):e29030. doi: 10.1002/jmv.29030. J Med Virol. 2023. PMID: 37565734
Although SHFL is widely acknowledged for its broad-spectrum antiviral activity, it remains elusive whether SHFL inhibits EV-A71. ...Furthermore, the zinc-finger domain and the 36 amino acids (164-199) of SHFL were crucial to the interaction between SHFL
Although SHFL is widely acknowledged for its broad-spectrum antiviral activity, it remains elusive whether SHFL inhibits EV-A7 …
The SARS-CoV-2 RNA interactome.
Lee S, Lee YS, Choi Y, Son A, Park Y, Lee KM, Kim J, Kim JS, Kim VN. Lee S, et al. Mol Cell. 2021 Jul 1;81(13):2838-2850.e6. doi: 10.1016/j.molcel.2021.04.022. Epub 2021 Apr 27. Mol Cell. 2021. PMID: 33989516 Free PMC article.
Transcriptome analyses and knockdown experiments delineated 17 antiviral RBPs, including ZC3HAV1, TRIM25, PARP12, and SHFL, and 8 proviral RBPs, such as EIF3D and CSDE1, which are responsible for co-opting multiple steps of the mRNA life cycle. ...
Transcriptome analyses and knockdown experiments delineated 17 antiviral RBPs, including ZC3HAV1, TRIM25, PARP12, and SHFL, and 8 pro …
Functional features of a novel interferon-stimulated gene SHFL: a comprehensive review.
Wang X, Zhang AM. Wang X, et al. Front Microbiol. 2023 Dec 11;14:1323231. doi: 10.3389/fmicb.2023.1323231. eCollection 2023. Front Microbiol. 2023. PMID: 38149274 Free PMC article. Review.
SHFL interacts with various viral and host molecules to inhibit viral life circle and activities, such as replication, translation, and ribosomal frameshifting, or regulates host pathways to degrade viral proteins. In this review, we summarized the functional features of
SHFL interacts with various viral and host molecules to inhibit viral life circle and activities, such as replication, translation, a
Shiftless, a Critical Piece of the Innate Immune Response to Viral Infection.
Rodriguez W, Muller M. Rodriguez W, et al. Viruses. 2022 Jun 20;14(6):1338. doi: 10.3390/v14061338. Viruses. 2022. PMID: 35746809 Free PMC article. Review.
Since its initial characterization in 2016, the interferon stimulated gene Shiftless (SHFL) has proven to be a critical piece of the innate immune response to viral infection. ...Recent literature has shown that SHFL expression also significantly impacts viral patho …
Since its initial characterization in 2016, the interferon stimulated gene Shiftless (SHFL) has proven to be a critical piece of the …
The antiviral protein Shiftless blocks p-body formation during KSHV infection.
Hatfield D, Rodriguez W, Mehrmann T, Muller M. Hatfield D, et al. bioRxiv [Preprint]. 2023 Nov 16:2023.11.16.567185. doi: 10.1101/2023.11.16.567185. bioRxiv. 2023. PMID: 38014318 Free PMC article. Preprint.
Mutational approaches revealed that SHFL RNA binding activity is not required for its PB disassembly function. ...SHFL-mediated PB disassembly also leads to increased expression of key anti-viral cytokines, further expanding SHFL dependent anti-viral state. . …
Mutational approaches revealed that SHFL RNA binding activity is not required for its PB disassembly function. ...SHFL-mediate …
Shiftless Restricts Viral Gene Expression and Influences RNA Granule Formation during Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication.
Rodriguez W, Mehrmann T, Hatfield D, Muller M. Rodriguez W, et al. J Virol. 2022 Nov 23;96(22):e0146922. doi: 10.1128/jvi.01469-22. Epub 2022 Nov 3. J Virol. 2022. PMID: 36326276 Free PMC article.
We next show that SHFL affects cytoplasmic RNA granule formation, triggering the disassembly of processing bodies. ...In this study, we set out to determine the mechanism by which SHFL restricts KSHV infection. We demonstrate that SHFL impacts all classes of …
We next show that SHFL affects cytoplasmic RNA granule formation, triggering the disassembly of processing bodies. ...In this study, …
TRIM5 Promotes Systemic Lupus Erythematosus Through CD4(+) T Cells and Macrophage.
Pan Z, Yang Q, Zhang X, Xu X, Sun Y, Zhou F, Wen L. Pan Z, et al. Int J Gen Med. 2023 Aug 18;16:3567-3580. doi: 10.2147/IJGM.S416493. eCollection 2023. Int J Gen Med. 2023. PMID: 37614552 Free PMC article.
Flow cytometry was used for verifying the proportion of naive CD4(+) T cells and M2 macrophages in PBMCs from 5 cases and 4 HCs. RESULTS: We found 14 genes (TRIM5, FAM8A1, SHFL, LHFPL2, PARP14, IFIT5, PARP12, DDX60, IRF7, IF144, OAS1, OAS3, RHBDF2, and RSAD2) that were dif …
Flow cytometry was used for verifying the proportion of naive CD4(+) T cells and M2 macrophages in PBMCs from 5 cases and 4 HCs. RESULTS: We …
Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses.
Zhang Y, Kinast V, Sheldon J, Frericks N, Todt D, Zimmer M, Caliskan N, Brown RJP, Steinmann E, Pietschmann T. Zhang Y, et al. Microbiol Spectr. 2023 Aug 17;11(4):e0128423. doi: 10.1128/spectrum.01284-23. Epub 2023 Jun 21. Microbiol Spectr. 2023. PMID: 37341610 Free PMC article.
To investigate whether liver intrinsic host factors can exhibit broad restriction against these distantly related hepaciviruses, we focused on Shiftless (Shfl), an interferon (IFN)-regulated gene (IRG) which restricts HCV in humans. ...Colocalization of mSHFL protein with …
To investigate whether liver intrinsic host factors can exhibit broad restriction against these distantly related hepaciviruses, we focused …
All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes.
Yang E, Li MMH. Yang E, et al. Front Immunol. 2020 Dec 9;11:605024. doi: 10.3389/fimmu.2020.605024. eCollection 2020. Front Immunol. 2020. PMID: 33362792 Free PMC article. Review.
While the OAS/RNase L pathway globally degrades RNA and arrests translation, ISG20 and ZAP employ targeted RNA degradation and translation inhibition to block viral replication. Meanwhile, SHFL targets translation by inhibiting -1 ribosomal frameshifting, which is required …
While the OAS/RNase L pathway globally degrades RNA and arrests translation, ISG20 and ZAP employ targeted RNA degradation and translation i …
24 results