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Page 1
The Good and the Bad of SHROOM3 in Kidney Development and Disease: A Narrative Review.
Paul A, Lawlor A, Cunanan K, Gaheer PS, Kalra A, Napoleone M, Lanktree MB, Bridgewater D. Paul A, et al. Can J Kidney Health Dis. 2023 Dec 13;10:20543581231212038. doi: 10.1177/20543581231212038. eCollection 2023. Can J Kidney Health Dis. 2023. PMID: 38107159 Free PMC article. Review.
Yet, an understanding of the molecular mechanisms behind the association of SHROOM3 and kidney disease remains poorly communicated. We conducted a narrative review to summarize the current state of literature regarding the genetic and molecular relationships between SHR …
Yet, an understanding of the molecular mechanisms behind the association of SHROOM3 and kidney disease remains poorly communicated. W …
Shroom3, a Gene Associated with CKD, Modulates Epithelial Recovery after AKI.
Li A, Cunanan J, Khalili H, Plageman T, Ask K, Khan A, Hunjan A, Drysdale T, Bridgewater D. Li A, et al. Kidney360. 2021 Nov 3;3(1):51-62. doi: 10.34067/KID.0003802021. eCollection 2022 Jan 27. Kidney360. 2021. PMID: 35368578 Free PMC article.
Here, we sought to further understand the associations of Shroom3 in CKD. METHODS: Kidney ischemia was induced in wild-type (WT) and Shroom3 heterozygous null mice (Shroom3(Gt/+) ) and the mechanisms of cellular recovery and repair were examined. ...CONCLUSIO …
Here, we sought to further understand the associations of Shroom3 in CKD. METHODS: Kidney ischemia was induced in wild-type (WT) and …
Minimal Kidney Disease Phenotype in Shroom3 Heterozygous Null Mice.
Lawlor A, Cunanan K, Cunanan J, Paul A, Khalili H, Ko D, Khan A, Gros R, Drysdale T, Bridgewater D. Lawlor A, et al. Can J Kidney Health Dis. 2023 Jun 7;10:20543581231165716. doi: 10.1177/20543581231165716. eCollection 2023. Can J Kidney Health Dis. 2023. PMID: 37313360 Free PMC article.
OBJECTIVE: Characterize the phenotypic abnormalities associated with reduced Shroom3 expression in postnatal day 3-, 1-month and 3-month-old mice. METHODS: The Shroom3 protein expression pattern was determined by immunofluorescence. We generated Shroom3 heter …
OBJECTIVE: Characterize the phenotypic abnormalities associated with reduced Shroom3 expression in postnatal day 3-, 1-month and 3-mo …
SHROOM3, the gene associated with chronic kidney disease, affects the podocyte structure.
Matsuura R, Hiraishi A, Holzman LB, Hanayama H, Harano K, Nakamura E, Hamasaki Y, Doi K, Nangaku M, Noiri E. Matsuura R, et al. Sci Rep. 2020 Dec 3;10(1):21103. doi: 10.1038/s41598-020-77952-9. Sci Rep. 2020. PMID: 33273487 Free PMC article.
Chronic kidney disease is a public health burden and it remains unknown which genetic loci are associated with kidney function in the Japanese population, our genome-wide association study using the Biobank Japan dataset (excluding secondary kidney diseases, such as diabetes mell …
Chronic kidney disease is a public health burden and it remains unknown which genetic loci are associated with kidney function in the Japane …
SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects.
Durbin MD, O'Kane J, Lorentz S, Firulli AB, Ware SM. Durbin MD, et al. Dev Biol. 2020 Aug 15;464(2):124-136. doi: 10.1016/j.ydbio.2020.05.013. Epub 2020 Jun 5. Dev Biol. 2020. PMID: 32511952 Free PMC article.
We previously implicated a novel CHD candidate gene, SHROOM3, in a patient with CHD. Using a Shroom3 gene trap knockout mouse (Shroom3(gt/gt)) we demonstrate that SHROOM3 is downstream of the noncanonical Wnt planar cell polarity signaling pathway (PCP …
We previously implicated a novel CHD candidate gene, SHROOM3, in a patient with CHD. Using a Shroom3 gene trap knockout mouse …
SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts.
Wei C, Banu K, Garzon F, Basgen JM, Philippe N, Yi Z, Liu R, Choudhuri J, Fribourg M, Liu T, Cumpelik A, Wong J, Khan M, Das B, Keung K, Salem F, Campbell KN, Kaufman L, Cravedi P, Zhang W, O'Connell PJ, He JC, Murphy B, Menon MC. Wei C, et al. J Am Soc Nephrol. 2018 Nov;29(11):2641-2657. doi: 10.1681/ASN.2018060573. Epub 2018 Oct 19. J Am Soc Nephrol. 2018. PMID: 30341149 Free PMC article.
However, other evidence suggests Shroom3 may have a protective role in glomerular development. METHODS: We used human data, Shroom3 knockdown podocytes, and inducible shRNA-mediated knockdown mice to study the role of Shroom3 in adult glomeruli. ...Although o …
However, other evidence suggests Shroom3 may have a protective role in glomerular development. METHODS: We used human data, Shroom …
Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity.
Yeo NC, O'Meara CC, Bonomo JA, Veth KN, Tomar R, Flister MJ, Drummond IA, Bowden DW, Freedman BI, Lazar J, Link BA, Jacob HJ. Yeo NC, et al. Genome Res. 2015 Jan;25(1):57-65. doi: 10.1101/gr.182881.114. Epub 2014 Oct 1. Genome Res. 2015. PMID: 25273069 Free PMC article.
Here we used an integrated approach combining zebrafish, rat, and human data to interrogate the function of an established GWAS locus (SHROOM3) lacking prior functional support for chronic kidney disease (CKD). Congenic mapping and sequence analysis in rats suggested Sh …
Here we used an integrated approach combining zebrafish, rat, and human data to interrogate the function of an established GWAS locus (SH …
Shroom3-Rock interaction and profibrotic function: Resolving mechanism of an intronic CKD risk allele.
Reghuvaran A, Kumar A, Lin Q, Rajeevan N, Sun Z, Shi H, Barsotti G, Tanvir EM, Pell J, Perincheri S, Wei C, Planoutene M, Eichmann A, Mas V, Zhang W, Das B, Cantley L, Xu L, He CJ, Menon MC. Reghuvaran A, et al. bioRxiv [Preprint]. 2024 Nov 23:2024.11.22.624409. doi: 10.1101/2024.11.22.624409. bioRxiv. 2024. PMID: 39605692 Free PMC article. Preprint.
However, beneficial roles for Shroom3 in proteinuria have also been reported suggesting pleiotropic effects. Here we focused on identifying the specific profibrotic Shroom3 motif. ...Importantly, ASD2delta-Sh3 did not develop albuminuria vs WT-Sh3, while mutating a …
However, beneficial roles for Shroom3 in proteinuria have also been reported suggesting pleiotropic effects. Here we focused on ident …
Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling.
Nishimura T, Takeichi M. Nishimura T, et al. Development. 2008 Apr;135(8):1493-502. doi: 10.1242/dev.019646. Epub 2008 Mar 13. Development. 2008. PMID: 18339671
Remodeling of epithelial sheets plays important roles in animal morphogenesis. Shroom3 is known to regulate the apical constriction of epithelial cells. Here, we show that Shroom3 binds ROCKs and recruits them to the epithelial apical junctions. We identified the …
Remodeling of epithelial sheets plays important roles in animal morphogenesis. Shroom3 is known to regulate the apical constriction o …
Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD.
Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy LG, Meijer FA, Geurts AM, Rauscher FJ 3rd, Ramaker R, Flister MJ, Jacob HJ, Mendenhall EM, Lazar J. Prokop JW, et al. J Am Soc Nephrol. 2018 May;29(5):1525-1535. doi: 10.1681/ASN.2017080856. Epub 2018 Feb 23. J Am Soc Nephrol. 2018. PMID: 29476007 Free PMC article.
Background Interpreting genetic variants is one of the greatest challenges impeding analysis of rapidly increasing volumes of genomic data from patients. For example, SHROOM3 is an associated risk gene for CKD, yet causative mechanism(s) of SHROOM3 allele(s) are unk …
Background Interpreting genetic variants is one of the greatest challenges impeding analysis of rapidly increasing volumes of genomic data f …
107 results