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15 results

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Page 1
CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation.
Fang H, Tronco AR, Bonora G, Nguyen T, Thakur J, Berletch JB, Filippova GN, Henikoff S, Shendure J, Noble WS, Duan Z, Disteche CM, Deng X. Fang H, et al. BMC Biol. 2025 Mar 3;23(1):68. doi: 10.1186/s12915-025-02137-7. BMC Biol. 2025. PMID: 40025499 Free PMC article.
Indeed, deletion but not inversion of a CTCF binding site at the boundary between the facultative escapee Car5b and its silent neighbor Siah1b results in a dramatic reduction of Car5b escape. This is associated with reduced CTCF and cohesin binding, which indicates loss of …
Indeed, deletion but not inversion of a CTCF binding site at the boundary between the facultative escapee Car5b and its silent neighbor S …
Normal p53 function in primary cells deficient for Siah genes.
Frew IJ, Dickins RA, Cuddihy AR, Del Rosario M, Reinhard C, O'Connell MJ, Bowtell DD. Frew IJ, et al. Mol Cell Biol. 2002 Dec;22(23):8155-64. doi: 10.1128/MCB.22.23.8155-8164.2002. Mol Cell Biol. 2002. PMID: 12417719 Free PMC article.
Primary thymocytes deficient for Siah1a, Siah2, or both Siah2 and Siah1a, E1A-transformed MEFs lacking Siah1a, Siah1b, or Siah2, and Siah1b-null ES cells all underwent normal p53-mediated apoptosis. Finally, inhibition of Siah1b expression in Siah2 Siah1a dou …
Primary thymocytes deficient for Siah1a, Siah2, or both Siah2 and Siah1a, E1A-transformed MEFs lacking Siah1a, Siah1b, or Siah2, and …
CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation.
Fang H, Tronco AR, Bonora G, Nguyen T, Thakur J, Berletch JB, Filippova GN, Henikoff S, Shendure J, Noble WS, Disteche CM, Deng X. Fang H, et al. bioRxiv [Preprint]. 2023 May 4:2023.05.04.539469. doi: 10.1101/2023.05.04.539469. bioRxiv. 2023. Update in: BMC Biol. 2025 Mar 03;23(1):68. doi: 10.1186/s12915-025-02137-7. PMID: 37205597 Free PMC article. Updated. Preprint.
Concordantly, deletion but not inversion of a CTCF binding site at the boundary between the facultative escape gene Car5b and its silent neighbor Siah1b resulted in loss of Car5b escape. Reduced CTCF binding and enrichment of a repressive mark over Car5b in cells with a bo …
Concordantly, deletion but not inversion of a CTCF binding site at the boundary between the facultative escape gene Car5b and its silent nei …
[In silico and systematic molecular evolutionary analysis of human SIAH1b inactivation].
Yano M, Imagawa E, Tada M, Moriuchi T. Yano M, et al. Hokkaido Igaku Zasshi. 2005 Mar;80(2):201-9. Hokkaido Igaku Zasshi. 2005. PMID: 15835302 Japanese.
It is reported that mice have three SIAH homolog genes, Siah1a, Siah1b and Siah2, while men have SIAH1 and SIAH2 genes. It has recently been reported that, among these genes, mouse Siah1b gene is a direct target of p53. However, the nature of human "SIAH1b" g …
It is reported that mice have three SIAH homolog genes, Siah1a, Siah1b and Siah2, while men have SIAH1 and SIAH2 genes. It has recent …
Genomic DNA hypomethylation is associated with neural tube defects induced by methotrexate inhibition of folate metabolism.
Wang X, Guan Z, Chen Y, Dong Y, Niu Y, Wang J, Zhang T, Niu B. Wang X, et al. PLoS One. 2015 Mar 30;10(3):e0121869. doi: 10.1371/journal.pone.0121869. eCollection 2015. PLoS One. 2015. PMID: 25822193 Free PMC article.
Methylation levels of genomic DNA decreased significantly in the embryonic neural tube tissue of NTD samples. 132 differentially methylated regions (35 low methylated regions and 97 high methylated regions) were selected by microarray. Two genes (Siah1b, Prkx) in Wnt signa …
Methylation levels of genomic DNA decreased significantly in the embryonic neural tube tissue of NTD samples. 132 differentially methylated …
Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung.
Favre CJ, Mancuso M, Maas K, McLean JW, Baluk P, McDonald DM. Favre CJ, et al. Am J Physiol Heart Circ Physiol. 2003 Nov;285(5):H1917-38. doi: 10.1152/ajpheart.00983.2002. Epub 2003 Jul 3. Am J Physiol Heart Circ Physiol. 2003. PMID: 12842817 Free article.
Also enriched were genes in semaphorin/neuropilin (Sema3c and Nrp1), ephrin/Eph (ephrin A1, B1, B2, and EphB4), delta/notch (Hey1, Jagged 2, Notch 1, Notch 4, Numb, and Siah1b), and Wingless (Frizzled-4 and Tle1) signaling pathways involved in vascular development and angi …
Also enriched were genes in semaphorin/neuropilin (Sema3c and Nrp1), ephrin/Eph (ephrin A1, B1, B2, and EphB4), delta/notch (Hey1, Jagged 2, …
Characterization of human homologs of the Drosophila seven in absentia (sina) gene.
Hu G, Chung YL, Glover T, Valentine V, Look AT, Fearon ER. Hu G, et al. Genomics. 1997 Nov 15;46(1):103-11. doi: 10.1006/geno.1997.4997. Genomics. 1997. PMID: 9403064 Free article.
However, one of three murine homologs, Siah1B, was strongly induced in fibroblasts undergoing apoptotic cell death. While a previous study suggested that SINA was a nuclear protein, epitope-tagged SINA and SIAH1 proteins were found in the cytoplasm of Drosophila and mammal …
However, one of three murine homologs, Siah1B, was strongly induced in fibroblasts undergoing apoptotic cell death. While a previous …
Identification and preliminary functional analysis of alternative splicing of Siah1 in Xenopus laevis.
Wen L, Liu J, Chen Y, Wu D. Wen L, et al. Biochem Biophys Res Commun. 2010 May 28;396(2):419-24. doi: 10.1016/j.bbrc.2010.04.107. Epub 2010 Apr 22. Biochem Biophys Res Commun. 2010. PMID: 20417182
In this study, we characterized two splicing forms, Siah1a and Siah1b, of the Xenopus seven in absentia homolog 1 gene (Siah1). Overexpression of xSiah1a led to severe suppression of embryo cleavage, while that of xSiah1b was not effective even at a high dose. ...
In this study, we characterized two splicing forms, Siah1a and Siah1b, of the Xenopus seven in absentia homolog 1 gene (Siah1). Overe …
15 results