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The thymidine phosphorylase inhibitor 5'-O-tritylinosine (KIN59) is an antiangiogenic multitarget fibroblast growth factor-2 antagonist.
Liekens S, Bronckaers A, Belleri M, Bugatti A, Sienaert R, Ribatti D, Nico B, Gigante A, Casanova E, Opdenakker G, Pérez-Pérez MJ, Balzarini J, Presta M. Liekens S, et al. Among authors: sienaert r. Mol Cancer Ther. 2012 Apr;11(4):817-29. doi: 10.1158/1535-7163.MCT-11-0738. Epub 2012 Feb 1. Mol Cancer Ther. 2012. PMID: 22302099
Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus.
McGuigan C, Pathirana RN, Migliore M, Adak R, Luoni G, Jones AT, Díez-Torrubia A, Camarasa MJ, Velázquez S, Henson G, Verbeken E, Sienaert R, Naesens L, Snoeck R, Andrei G, Balzarini J. McGuigan C, et al. Among authors: sienaert r. J Antimicrob Chemother. 2007 Dec;60(6):1316-30. doi: 10.1093/jac/dkm376. Epub 2007 Oct 22. J Antimicrob Chemother. 2007. PMID: 17956908
Metabolic and pharmacological characteristics of the bicyclic nucleoside analogues (BCNAs) as highly selective inhibitors of varicella-zoster virus (VZV).
Sienaert R, Naesens L, Brancale A, Carangio A, Andrei G, Snoeck R, Van Kuilenburg A, De Clercq E, McGuigan C, Balzarini J. Sienaert R, et al. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):995-7. doi: 10.1081/NCN-120022721. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565329 No abstract available.