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Page 1
The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis.
He X, Ge C, Xia J, Xia Z, Zhao L, Huang S, Wang R, Pan J, Cheng T, Xu PF, Wang F, Min J. He X, et al. Adv Sci (Weinh). 2023 Jun;10(17):e2205345. doi: 10.1002/advs.202205345. Epub 2023 Apr 17. Adv Sci (Weinh). 2023. PMID: 37068188 Free PMC article.
The role of zinc in hematopoiesis is currently unclear. Here, SLC39A10 (ZIP10) is identified as a key zinc transporter in hematopoiesis. The results show that in zebrafish, Slc39a10 is a key regulator of the response to zinc deficiency. ...Together, these findings i …
The role of zinc in hematopoiesis is currently unclear. Here, SLC39A10 (ZIP10) is identified as a key zinc transporter in hematopoies …
SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways.
Ren X, Feng C, Wang Y, Chen P, Wang S, Wang J, Cao H, Li Y, Ji M, Hou P. Ren X, et al. Exp Mol Med. 2023 Aug;55(8):1757-1769. doi: 10.1038/s12276-023-01062-5. Epub 2023 Aug 1. Exp Mol Med. 2023. PMID: 37524874 Free PMC article.
Previous studies have reported that its upregulation promotes breast cancer metastasis by enhancing the influx of zinc ions (Zn(2+)); however, its role in gastric cancer remains totally unclear. Here, we found that SLC39A10 expression was frequently increased in gastric ad …
Previous studies have reported that its upregulation promotes breast cancer metastasis by enhancing the influx of zinc ions (Zn(2+)); howeve …
SLC39A10 Upregulation Predicts Poor Prognosis, Promotes Proliferation and Migration, and Correlates with Immune Infiltration in Hepatocellular Carcinoma.
Ma Z, Li Z, Wang S, Zhou Q, Ma Z, Liu C, Huang B, Zheng Z, Yang L, Zou Y, Zhang C, Huang S, Hou B. Ma Z, et al. J Hepatocell Carcinoma. 2021 Aug 7;8:899-912. doi: 10.2147/JHC.S320326. eCollection 2021. J Hepatocell Carcinoma. 2021. PMID: 34395329 Free PMC article.
BACKGROUND: Recent evidence has shown that Solute Carrier Family 39 Member 10 (SLC39A10) promoted tumor progression in several cancer types. The study intended to explore the expression and function of SLC39A10 in hepatocellular carcinoma (HCC). METHODS: Multiple bi …
BACKGROUND: Recent evidence has shown that Solute Carrier Family 39 Member 10 (SLC39A10) promoted tumor progression in several cancer …
SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease.
Shao Y, Mu Q, Wang R, Luo H, Song Z, Wang P, Song J, Ge C, Zhang J, Min J, Wang F. Shao Y, et al. Sci China Life Sci. 2025 Jul;68(7):1855-1870. doi: 10.1007/s11427-024-2817-y. Epub 2025 Jan 22. Sci China Life Sci. 2025. PMID: 39862347
We previously reported that the zinc transporter SLC39A10, located in the cell membrane, critically regulates the susceptibility of macrophages to inflammatory stimuli; however, the functional role of SLC39A10 in T cells is currently unknown. ...Mechanistically, we …
We previously reported that the zinc transporter SLC39A10, located in the cell membrane, critically regulates the susceptibility of m …
Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival.
Gao H, Zhao L, Wang H, Xie E, Wang X, Wu Q, Yu Y, He X, Ji H, Rink L, Min J, Wang F. Gao H, et al. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12940-12945. doi: 10.1073/pnas.1708018114. Epub 2017 Nov 27. Proc Natl Acad Sci U S A. 2017. PMID: 29180421 Free PMC article.
Compared with Slc39a10(fl/fl) mice, Slc39a10(fl/fl);LysM-Cre(+) mice had significantly lower mortality following LPS stimulation as well as reduced liver damage and lower levels of circulating inflammatory cytokines. ...Concomitant knockout of p53 largely rescued th …
Compared with Slc39a10(fl/fl) mice, Slc39a10(fl/fl);LysM-Cre(+) mice had significantly lower mortality following LPS stimulati …
Dual inhibition of MYC and SLC39A10 by a novel natural product STAT3 inhibitor derived from Chaetomium globosum suppresses tumor growth and metastasis in gastric cancer.
Guan X, Yang J, Wang W, Zhao B, Hu S, Yu D, Yuan L, Shi Y, Xu J, Dong J, Wang J, Cheng XD, Qin JJ. Guan X, et al. Pharmacol Res. 2023 Mar;189:106703. doi: 10.1016/j.phrs.2023.106703. Epub 2023 Feb 17. Pharmacol Res. 2023. PMID: 36804016 Free article.
The molecular mechanism studies based on transcriptomics and proteomics analyses indicated that XYA-2 might exert its anticancer activity by synergistically inhibiting the expression of MYC and SLC39A10, two downstream genes of STAT3 in vitro and in vivo. Together, these f …
The molecular mechanism studies based on transcriptomics and proteomics analyses indicated that XYA-2 might exert its anticancer activity by …
Endometrial zinc transporter Slc39a10/Zip10 is indispensable for progesterone responsiveness and successful pregnancy in mice.
Kawata Y, Terakawa J, Takeshita A, Namiki T, Kageyama A, Noguchi M, Murakami H, Fukada T, Ito J, Kashiwazaki N. Kawata Y, et al. PNAS Nexus. 2025 Feb 10;4(2):pgaf047. doi: 10.1093/pnasnexus/pgaf047. eCollection 2025 Feb. PNAS Nexus. 2025. PMID: 39967682 Free PMC article.
We observed that a uterine-specific genetic deletion of Slc39a10/Zip10, which encodes one of the zinc transporters to elevate the cytoplasmic level of zinc, results in female infertility due to failure of embryo invasion into the endometrium and subsequent embryonic loss. …
We observed that a uterine-specific genetic deletion of Slc39a10/Zip10, which encodes one of the zinc transporters to elevate the cyt …
Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength.
Hojyo S, Miyai T, Fujishiro H, Kawamura M, Yasuda T, Hijikata A, Bin BH, Irié T, Tanaka J, Atsumi T, Murakami M, Nakayama M, Ohara O, Himeno S, Yoshida H, Koseki H, Ikawa T, Mishima K, Fukada T. Hojyo S, et al. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11786-91. doi: 10.1073/pnas.1323557111. Epub 2014 Jul 29. Proc Natl Acad Sci U S A. 2014. PMID: 25074919 Free PMC article.
Here, we show that the Zn transporter SLC39A10/ZIP10 plays an important role in B-cell antigen receptor (BCR) signal transduction. ...
Here, we show that the Zn transporter SLC39A10/ZIP10 plays an important role in B-cell antigen receptor (BCR) signal transduction. .. …
63 results