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A role for zinc transporter gene SLC39A12 in the nervous system and beyond.
Davis DN, Strong MD, Chambers E, Hart MD, Bettaieb A, Clarke SL, Smith BJ, Stoecker BJ, Lucas EA, Lin D, Chowanadisai W. Davis DN, et al. Gene. 2021 Oct 5;799:145824. doi: 10.1016/j.gene.2021.145824. Epub 2021 Jul 9. Gene. 2021. PMID: 34252531 Free PMC article. Review.
The SLC39A12 gene encodes the zinc transporter protein ZIP12, which is expressed across many tissues and is highly abundant in the vertebrate nervous system. ...
The SLC39A12 gene encodes the zinc transporter protein ZIP12, which is expressed across many tissues and is highly abundant in the ve …
Loss of Slc39a12 in hippocampal neurons is responsible for anxiety-like behavior caused by temporomandibular joint osteoarthritis.
Shen Z, Fan C, Ding C, Xu M, Wu X, Wang Y, Xing T. Shen Z, et al. Heliyon. 2024 Feb 10;10(4):e26271. doi: 10.1016/j.heliyon.2024.e26271. eCollection 2024 Feb 29. Heliyon. 2024. PMID: 38375280 Free PMC article.
Increased Nox4 expression, decreased SOD2 expression, elevated MDA level, and reduced GSH level were detected in serum and hippocampal neurons in the MIA group, with nuclear pyknosis and reduced Nissl bodies observed in neurons. The expression of Slc39a12 in hippocampal ne …
Increased Nox4 expression, decreased SOD2 expression, elevated MDA level, and reduced GSH level were detected in serum and hippocampal neuro …
A Post-GWAS Functional Analysis Confirming Effects of Three BTA13 Genes CACNB2, SLC39A12, and ZEB1 on Dairy Cattle Reproduction.
Sammad A, Zhang H, Shi R, Dong Y, Luo H, Chen Z, Liu L, Guo G, Liu A, Wang Y. Sammad A, et al. Front Genet. 2022 Jun 8;13:882951. doi: 10.3389/fgene.2022.882951. eCollection 2022. Front Genet. 2022. PMID: 35754833 Free PMC article.
In our previous GWAS of Chinese and Nordic dairy cattle, genes CACNB2, SLC39A12, and ZEB1 locating on BTA 13 were suggested as candidate genes for reproduction. ...This study successfully demonstrated the associations of three BTA 13 genes CACNB2, SLC39A12, and ZEB1 …
In our previous GWAS of Chinese and Nordic dairy cattle, genes CACNB2, SLC39A12, and ZEB1 locating on BTA 13 were suggested as candid …
Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12).
Chowanadisai W, Graham DM, Keen CL, Rucker RB, Messerli MA. Chowanadisai W, et al. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9903-8. doi: 10.1073/pnas.1222142110. Epub 2013 May 28. Proc Natl Acad Sci U S A. 2013. PMID: 23716681 Free PMC article.
Systematic analysis of tissue-profiling microarray data showed that the zinc transporter ZIP12 (slc39a12) is highly expressed in the human brain. In the work reported here, we confirmed that ZIP12 is a Zn(2+) uptake transporter with a conserved pattern of high expression i …
Systematic analysis of tissue-profiling microarray data showed that the zinc transporter ZIP12 (slc39a12) is highly expressed in the …
Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia.
Scarr E, Udawela M, Greenough MA, Neo J, Suk Seo M, Money TT, Upadhyay A, Bush AI, Everall IP, Thomas EA, Dean B. Scarr E, et al. NPJ Schizophr. 2016 Mar 9;2:16002. doi: 10.1038/npjschz.2016.2. eCollection 2016. NPJ Schizophr. 2016. PMID: 27336053 Free PMC article.
In addition, we determined whether inducing the expression of SLC39A12 resulted in an increased cellular zinc uptake. SLC39A12 variant 1 and 2 mRNA was measured using quantitative PCR. Zinc uptake was measured in CHO cells transfected with human SLC39A12 vari …
In addition, we determined whether inducing the expression of SLC39A12 resulted in an increased cellular zinc uptake. SLC39A12 …
Changes in levels of the zinc transporter SLC39A12 in Brodmann's area 44: Effects of sex, suicide, CNS pH and schizophrenia.
Dean B, Hopper S, Scarr E. Dean B, et al. J Psychiatr Res. 2024 Sep;177:177-184. doi: 10.1016/j.jpsychires.2024.07.017. Epub 2024 Jul 14. J Psychiatr Res. 2024. PMID: 39024742
For the first time, in our study cohort as a whole, we report levels of both splice variants of SLC39A12 are lower in females compared to males and there are correlations between levels of SLC39A12 a and b and CNS pH. ...Accounting for these factors, we showed level …
For the first time, in our study cohort as a whole, we report levels of both splice variants of SLC39A12 are lower in females compare …
Comparative genomic analysis of slc39a12/ZIP12: insight into a zinc transporter required for vertebrate nervous system development.
Chowanadisai W. Chowanadisai W. PLoS One. 2014 Nov 6;9(11):e111535. doi: 10.1371/journal.pone.0111535. eCollection 2014. PLoS One. 2014. PMID: 25375179 Free PMC article.
The zinc transporter ZIP12, which is encoded by the gene slc39a12, has previously been shown to be important for neuronal differentiation in mouse Neuro-2a neuroblastoma cells and primary mouse neurons and necessary for neurulation during Xenopus tropicalis embryogenesis. …
The zinc transporter ZIP12, which is encoded by the gene slc39a12, has previously been shown to be important for neuronal differentia …
Identification of autosomal recessive novel genes and retinal phenotypes in members of the solute carrier (SLC) superfamily.
Millo T, Rivera A, Obolensky A, Marks-Ohana D, Xu M, Li Y, Wilhelm E, Gopalakrishnan P, Gross M, Rosin B, Hanany M, Webster A, Tracewska AM, Koenekoop RK, Chen R, Arno G, Schueler-Furman O, Roosing S, Banin E, Sharon D. Millo T, et al. Genet Med. 2022 Jul;24(7):1523-1535. doi: 10.1016/j.gim.2022.03.020. Epub 2022 Apr 29. Genet Med. 2022. PMID: 35486108 Free article.
RESULTS: Comprehensive analysis of 433 SLC genes in 913 exome sequencing IRD samples revealed homozygous pathogenic variants in 6 SLC genes, including 2 candidate novel genes, which were 2 variants in SLC66A1, causing autosomal recessive retinitis pigmentosa (ARRP), and a variant …
RESULTS: Comprehensive analysis of 433 SLC genes in 913 exome sequencing IRD samples revealed homozygous pathogenic variants in 6 SLC genes, …
Role of zinc transporter ZIP12 in susceptibility-weighted brain magnetic resonance imaging (MRI) phenotypes and mitochondrial function.
Strong MD, Hart MD, Tang TZ, Ojo BA, Wu L, Nacke MR, Agidew WT, Hwang HJ, Hoyt PR, Bettaieb A, Clarke SL, Smith BJ, Stoecker BJ, Lucas EA, Lin D, Chowanadisai W. Strong MD, et al. FASEB J. 2020 Sep;34(9):10702-12725. doi: 10.1096/fj.202000772R. Epub 2020 Jul 27. FASEB J. 2020. PMID: 32716562
Coding ZIP12 polymorphisms in zinc transporter ZIP12 (SLC39A12) were associated with altered brain susceptibility weighted MRI (swMRI). Conditional and joint association analyses revealed independent GWAS signals in linkage disequilibrium with 2 missense ZIP12 polymorphism …
Coding ZIP12 polymorphisms in zinc transporter ZIP12 (SLC39A12) were associated with altered brain susceptibility weighted MRI (swMRI …
29 results