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A role for zinc transporter gene SLC39A12 in the nervous system and beyond.
Davis DN, Strong MD, Chambers E, Hart MD, Bettaieb A, Clarke SL, Smith BJ, Stoecker BJ, Lucas EA, Lin D, Chowanadisai W. Davis DN, et al. Gene. 2021 Oct 5;799:145824. doi: 10.1016/j.gene.2021.145824. Epub 2021 Jul 9. Gene. 2021. PMID: 34252531 Free PMC article. Review.
The SLC39A12 gene encodes the zinc transporter protein ZIP12, which is expressed across many tissues and is highly abundant in the vertebrate nervous system. ...
The SLC39A12 gene encodes the zinc transporter protein ZIP12, which is expressed across many tissues and is highly abundant in the ve …
Loss of Slc39a12 in hippocampal neurons is responsible for anxiety-like behavior caused by temporomandibular joint osteoarthritis.
Shen Z, Fan C, Ding C, Xu M, Wu X, Wang Y, Xing T. Shen Z, et al. Heliyon. 2024 Feb 10;10(4):e26271. doi: 10.1016/j.heliyon.2024.e26271. eCollection 2024 Feb 29. Heliyon. 2024. PMID: 38375280 Free PMC article.
Increased Nox4 expression, decreased SOD2 expression, elevated MDA level, and reduced GSH level were detected in serum and hippocampal neurons in the MIA group, with nuclear pyknosis and reduced Nissl bodies observed in neurons. The expression of Slc39a12 in hippocampal ne …
Increased Nox4 expression, decreased SOD2 expression, elevated MDA level, and reduced GSH level were detected in serum and hippocampal neuro …
Changes in levels of the zinc transporter SLC39A12 in Brodmann's area 44: Effects of sex, suicide, CNS pH and schizophrenia.
Dean B, Hopper S, Scarr E. Dean B, et al. J Psychiatr Res. 2024 Sep;177:177-184. doi: 10.1016/j.jpsychires.2024.07.017. Epub 2024 Jul 14. J Psychiatr Res. 2024. PMID: 39024742
For the first time, in our study cohort as a whole, we report levels of both splice variants of SLC39A12 are lower in females compared to males and there are correlations between levels of SLC39A12 a and b and CNS pH. ...Accounting for these factors, we showed level …
For the first time, in our study cohort as a whole, we report levels of both splice variants of SLC39A12 are lower in females compare …
A Post-GWAS Functional Analysis Confirming Effects of Three BTA13 Genes CACNB2, SLC39A12, and ZEB1 on Dairy Cattle Reproduction.
Sammad A, Zhang H, Shi R, Dong Y, Luo H, Chen Z, Liu L, Guo G, Liu A, Wang Y. Sammad A, et al. Front Genet. 2022 Jun 8;13:882951. doi: 10.3389/fgene.2022.882951. eCollection 2022. Front Genet. 2022. PMID: 35754833 Free PMC article.
In our previous GWAS of Chinese and Nordic dairy cattle, genes CACNB2, SLC39A12, and ZEB1 locating on BTA 13 were suggested as candidate genes for reproduction. ...This study successfully demonstrated the associations of three BTA 13 genes CACNB2, SLC39A12, and ZEB1 …
In our previous GWAS of Chinese and Nordic dairy cattle, genes CACNB2, SLC39A12, and ZEB1 locating on BTA 13 were suggested as candid …
Comparative genomic analysis of slc39a12/ZIP12: insight into a zinc transporter required for vertebrate nervous system development.
Chowanadisai W. Chowanadisai W. PLoS One. 2014 Nov 6;9(11):e111535. doi: 10.1371/journal.pone.0111535. eCollection 2014. PLoS One. 2014. PMID: 25375179 Free PMC article.
The zinc transporter ZIP12, which is encoded by the gene slc39a12, has previously been shown to be important for neuronal differentiation in mouse Neuro-2a neuroblastoma cells and primary mouse neurons and necessary for neurulation during Xenopus tropicalis embryogenesis. …
The zinc transporter ZIP12, which is encoded by the gene slc39a12, has previously been shown to be important for neuronal differentia …
Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12).
Chowanadisai W, Graham DM, Keen CL, Rucker RB, Messerli MA. Chowanadisai W, et al. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9903-8. doi: 10.1073/pnas.1222142110. Epub 2013 May 28. Proc Natl Acad Sci U S A. 2013. PMID: 23716681 Free PMC article.
Systematic analysis of tissue-profiling microarray data showed that the zinc transporter ZIP12 (slc39a12) is highly expressed in the human brain. In the work reported here, we confirmed that ZIP12 is a Zn(2+) uptake transporter with a conserved pattern of high expression i …
Systematic analysis of tissue-profiling microarray data showed that the zinc transporter ZIP12 (slc39a12) is highly expressed in the …
Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia.
Scarr E, Udawela M, Greenough MA, Neo J, Suk Seo M, Money TT, Upadhyay A, Bush AI, Everall IP, Thomas EA, Dean B. Scarr E, et al. NPJ Schizophr. 2016 Mar 9;2:16002. doi: 10.1038/npjschz.2016.2. eCollection 2016. NPJ Schizophr. 2016. PMID: 27336053 Free PMC article.
In addition, we determined whether inducing the expression of SLC39A12 resulted in an increased cellular zinc uptake. SLC39A12 variant 1 and 2 mRNA was measured using quantitative PCR. Zinc uptake was measured in CHO cells transfected with human SLC39A12 vari …
In addition, we determined whether inducing the expression of SLC39A12 resulted in an increased cellular zinc uptake. SLC39A12 …
Identification of genes underlying nigrostriatal iron accumulation: transcriptome-wide association study of iron-sensitive brain MRI.
Welton T, Saw WT, Zhou Z, Sun Q, Mai AS, Teo TWJ, Chan LL, Tan LCS, Tan EK. Welton T, et al. EBioMedicine. 2026 Jan;123:106076. doi: 10.1016/j.ebiom.2025.106076. Epub 2025 Dec 10. EBioMedicine. 2026. PMID: 41380477 Free PMC article.
Replicated genes converged on metal ion transport and inflammatory pathways, with notable associations involving calcium channel (CACNB2), zinc transporter (SLC39A12/ZIP12), and sorting nexin (SNX31) genes. SMR + HEIDI and colocalisation highlighted several putatively caus …
Replicated genes converged on metal ion transport and inflammatory pathways, with notable associations involving calcium channel (CACNB2), z …
Genome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins.
Liu A, Wang Y, Sahana G, Zhang Q, Liu L, Lund MS, Su G. Liu A, et al. Sci Rep. 2017 Aug 16;7(1):8487. doi: 10.1038/s41598-017-09170-9. Sci Rep. 2017. PMID: 28814769 Free PMC article.
Furthermore, multiple novel variants identified in Chinese Holsteins were validated with Nordic data as well as meta-analyses. The genes IL6R, SLC39A12, CACNB2, ZEB1, ZMIZ1 and FAM213A were concluded to be strong candidate genes for female fertility in Holsteins....
Furthermore, multiple novel variants identified in Chinese Holsteins were validated with Nordic data as well as meta-analyses. The genes IL6 …
32 results