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SLC41A1 knockout mice display normal magnesium homeostasis.
Ilenwabor BP, Franken GAC, Sponder G, Bos C, Racay P, Kolisek M, Hoenderop JGJ, de Baaij JHF. Ilenwabor BP, et al. Am J Physiol Renal Physiol. 2022 Nov 1;323(5):F553-F563. doi: 10.1152/ajprenal.00101.2022. Epub 2022 Sep 1. Am J Physiol Renal Physiol. 2022. PMID: 36049064 Free article.
In this study, we generated a SLC41A1 knockout mouse model to examine the role of SLC41A1 in Mg(2+) homeostasis. Slc41a1(-/-) mice exhibited similar serum and urine Mg(2+) levels as their wild-type littermates. ...This study investigated the role of SLC41A …
In this study, we generated a SLC41A1 knockout mouse model to examine the role of SLC41A1 in Mg(2+) homeostasis. Slc41a1 …
SLC41A1 is essential for magnesium homeostasis in vivo.
Arjona FJ, Latta F, Mohammed SG, Thomassen M, van Wijk E, Bindels RJM, Hoenderop JGJ, de Baaij JHF. Arjona FJ, et al. Pflugers Arch. 2019 Jun;471(6):845-860. doi: 10.1007/s00424-018-2234-9. Epub 2018 Nov 12. Pflugers Arch. 2019. PMID: 30417250 Free PMC article.
However, the physiological function of SLC41A1 remains to be elucidated. In this study, cellular Mg(2+) transport assays combined with zebrafish slc41a1 knockdown experiments were performed to disclose SLC41A1 function and its physiological relevance. ...Impo …
However, the physiological function of SLC41A1 remains to be elucidated. In this study, cellular Mg(2+) transport assays combined wit …
SLC41A1 overexpression correlates with immune cell infiltration in HCC and promotes its malignant progression.
Chen G, Du Z, Rao C. Chen G, et al. Int J Med Sci. 2024 Nov 11;21(15):3069-3082. doi: 10.7150/ijms.100155. eCollection 2024. Int J Med Sci. 2024. PMID: 39628683 Free PMC article.
Recent studies revealed SLC41A3 acted as an oncogene and predicted poor survival for hepatocellular carcinoma (HCC) patients. However, the potential function of SLC41A1 in HCC remains unclear. In our study, we focused on the levels and putative mechanisms of SLC41A1 …
Recent studies revealed SLC41A3 acted as an oncogene and predicted poor survival for hepatocellular carcinoma (HCC) patients. However, the p …
SLC41A1 Mg(2+) transport is regulated via Mg(2+)-dependent endosomal recycling through its N-terminal cytoplasmic domain.
Mandt T, Song Y, Scharenberg AM, Sahni J. Mandt T, et al. Biochem J. 2011 Oct 1;439(1):129-39. doi: 10.1042/BJ20110807. Biochem J. 2011. PMID: 21696366
SLC41A1 (solute carrier family 41, member A1) is a recently described vertebrate member of the MgtE family of Mg(2+) transporters. ...Taken together, our results indicate that SLC41A1 proteins are a central component of vertebrate Mg(2+) transport systems, and that …
SLC41A1 (solute carrier family 41, member A1) is a recently described vertebrate member of the MgtE family of Mg(2+) transporters. .. …
SLC41A1 is a novel mammalian Mg2+ carrier.
Kolisek M, Launay P, Beck A, Sponder G, Serafini N, Brenkus M, Froschauer EM, Martens H, Fleig A, Schweigel M. Kolisek M, et al. J Biol Chem. 2008 Jun 6;283(23):16235-47. doi: 10.1074/jbc.M707276200. Epub 2008 Mar 25. J Biol Chem. 2008. PMID: 18367447 Free PMC article.
Thus, we have identified human SLC41A1 as being a bona fide magnesium transporter. Most importantly, overexpressed SLC41A1 provide HEK293 cells with an increased magnesium efflux capacity. ...Taken together, these data functionally identify SLC41A1 as a mamma …
Thus, we have identified human SLC41A1 as being a bona fide magnesium transporter. Most importantly, overexpressed SLC41A1 pro …
SLC41A1, a Na(+)/Mg(2+) exchanger, is downregulated during exercise.
Tseng AP, Wei H, Hsiung N, Chen SH, Chen HY, Cheng FC. Tseng AP, et al. Biomed Rep. 2014 Jul;2(4):599-601. doi: 10.3892/br.2014.289. Epub 2014 May 21. Biomed Rep. 2014. PMID: 24944816 Free PMC article.
The purpose of this study was to examine the gene expression of SLC41A1, a Na(+)/Mg(2+) exchanger, during exercise. In the present study, male C57BL/6JNarl mice (n=16, 8 weeks old) were subjected to 3 h forced exercise on a treadmill. ...Blood samples were obtained at thre …
The purpose of this study was to examine the gene expression of SLC41A1, a Na(+)/Mg(2+) exchanger, during exercise. In the present st …
SLC41A1 knockdown inhibits angiotensin II-induced cardiac fibrosis by preventing Mg(2+) efflux and Ca(2+) signaling in cardiac fibroblasts.
Yu N, Jiang J, Yu Y, Li H, Huang X, Ma Y, Zhang L, Zou J, Zhang B, Chen S, Liu P. Yu N, et al. Arch Biochem Biophys. 2014 Dec 15;564:74-82. doi: 10.1016/j.abb.2014.09.013. Epub 2014 Sep 27. Arch Biochem Biophys. 2014. PMID: 25263961
Na(+)/Mg(2+) exchanger plays an important role in cardiovascular system, but the molecular mechanisms still largely remain unknown. The Solute Carrier family 41A1 (SLC41A1), a novel Mg(2+) transporter, recently was found to function as Na(+)/Mg(2+) exchanger, which mainly …
Na(+)/Mg(2+) exchanger plays an important role in cardiovascular system, but the molecular mechanisms still largely remain unknown. The Solu …
Magnesium and Drugs.
Gröber U. Gröber U. Int J Mol Sci. 2019 Apr 28;20(9):2094. doi: 10.3390/ijms20092094. Int J Mol Sci. 2019. PMID: 31035385 Free PMC article. Review.
SLC41A1 and TRPM7 in magnesium homeostasis and genetic risk for Parkinson's disease.
Sturgeon M, Wu P, Cornell R. Sturgeon M, et al. J Neurol Neuromedicine. 2016;1(9):23-28. Epub 2016 Dec 30. J Neurol Neuromedicine. 2016. PMID: 31187092 Free PMC article.
First, the gene encoding magnesium transporter SLC41A1 is, among others, a candidate for the causative gene in the PARK16 locus where variation is associated with risk for idiopathic Parkinsonian disease. Studies of the function of SLC41A1 in animal models are neede …
First, the gene encoding magnesium transporter SLC41A1 is, among others, a candidate for the causative gene in the PARK16 locus where …
Nature of SLC41A1 complexes: report on the split-ubiquitin yeast two hybrid assay.
Nestler A, Sponder G, Rutschmann K, Mastrototaro L, Weise C, Vormann J, Schweigel-Röntgen M, Kolisek M. Nestler A, et al. Magnes Res. 2013 Apr-Jun;26(2):56-66. doi: 10.1684/mrh.2013.0339. Magnes Res. 2013. PMID: 23823179 Free article.
Among the singletons, we identified SLC31A2, SLC35B1, SLC39A13, CRACM1, and MTCH2 as putative binding partners of SLC41A1. Interestingly, we did not identify interactions among SLC41A1 molecules. Most of the identified interactors are integral proteins localized in …
Among the singletons, we identified SLC31A2, SLC35B1, SLC39A13, CRACM1, and MTCH2 as putative binding partners of SLC41A1. Interestin …
94 results