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Page 1
Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes.
Kim DH, Choi HI, Park JS, Kim CS, Bae EH, Ma SK, Kim SW. Kim DH, et al. Redox Biol. 2022 Aug;54:102382. doi: 10.1016/j.redox.2022.102382. Epub 2022 Jun 23. Redox Biol. 2022. PMID: 35767918 Free PMC article.
Additionally, chromatin immunoprecipitation assays, using mice renal tissues, revealed that agonist-activated FXR could bind to its known target genes (Slc51a, Slc51b, Osgin1, and Mafg) and ferroptosis-related genes (Aifm2, Ggt6, and Gsta4). ...
Additionally, chromatin immunoprecipitation assays, using mice renal tissues, revealed that agonist-activated FXR could bind to its known ta …
Fat Malabsorption and Ursodeoxycholic Acid Treatment in Children With Reduced Organic Solute Transporter-alpha (SLC51A) Expression.
Tronstad RR, Berland S, Tjora E, El Jellas K, Aukrust I, Kristensen K, Tveitnes D, Molven A, Marschall HU, Rao A, Dawson PA. Tronstad RR, et al. JPGN Rep. 2022 Aug;3(3):e229. doi: 10.1097/pg9.0000000000000229. Epub 2022 Jul 25. JPGN Rep. 2022. PMID: 36148443 Free PMC article.
RESULTS: A novel homozygous variant of SLC51A, which encodes the bile acid carrier organic solute transporter (OST)-alpha, was identified in all affected children. ...The clinical presentation partially overlaps previous reports for 3 patients with OSTalpha or OSTbeta defi …
RESULTS: A novel homozygous variant of SLC51A, which encodes the bile acid carrier organic solute transporter (OST)-alpha, was identi …
The heteromeric organic solute transporter, OSTα-OSTβ/SLC51: a transporter for steroid-derived molecules.
Ballatori N, Christian WV, Wheeler SG, Hammond CL. Ballatori N, et al. Mol Aspects Med. 2013 Apr-Jun;34(2-3):683-92. doi: 10.1016/j.mam.2012.11.005. Mol Aspects Med. 2013. PMID: 23506901 Free PMC article. Review.
The transporter is composed of two gene products encoded by SLC51A and SLC51B that heterodimerize to form the functional transporter complex. SLC51A encodes OSTalpha, a predicted 340-amino acid, 7-transmembrane (TM) domain protein, whereas SLC51B encodes OSTbeta, a …
The transporter is composed of two gene products encoded by SLC51A and SLC51B that heterodimerize to form the functional transporter …
Cholangiocyte organoids to study drug-induced injury.
Wang Z, Xing C, van der Laan LJW, Verstegen MMA, Spee B, Masereeuw R. Wang Z, et al. Stem Cell Res Ther. 2024 Mar 13;15(1):78. doi: 10.1186/s13287-024-03692-6. Stem Cell Res Ther. 2024. PMID: 38475870 Free PMC article.
The drug also decreased expression of three main basolateral bile acid transporters, ABCC3 (ATP binding cassette subfamily C member 3), SLC51A/B (solute carrier family 51 subunit alpha/beta) and multidrug resistance transporter ABCB1 (ATP binding cassette subfamily B membe …
The drug also decreased expression of three main basolateral bile acid transporters, ABCC3 (ATP binding cassette subfamily C member 3), S …
Targeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology.
Kunst RF, Verkade HJ, Oude Elferink RPJ, van de Graaf SFJ. Kunst RF, et al. Hepatology. 2021 Jun;73(6):2577-2585. doi: 10.1002/hep.31651. Epub 2021 May 24. Hepatology. 2021. PMID: 33222321 Free PMC article. Review.
Starting from the intestinal lumen, conjugated bile salts cross the otherwise impermeable lipid bilayer of (primarily terminal ileal) enterocytes through the apical sodium-dependent bile acid transporter (gene SLC10A2) and leave the enterocyte through the basolateral heteromeric …
Starting from the intestinal lumen, conjugated bile salts cross the otherwise impermeable lipid bilayer of (primarily terminal ileal) entero …
A systems-level analysis of bile acids effects on rat colon epithelial cells.
Yde J, Wu Q, Borg JF, Fenton RA, Moeller HB. Yde J, et al. Am J Physiol Gastrointest Liver Physiol. 2022 Jan 1;322(1):G34-G48. doi: 10.1152/ajpgi.00178.2021. Epub 2021 Oct 13. Am J Physiol Gastrointest Liver Physiol. 2022. PMID: 34643455 Free article.
Among the altered genes were genes associated with electrolyte and water transport (including Slc12a7, Clca4, and Aqp3) and genes associated with bile acid transport (Slc2b1, Abcg2, Slc51a, Slc51b, and Fabps). Correlation analysis showed a significant positive correlation …
Among the altered genes were genes associated with electrolyte and water transport (including Slc12a7, Clca4, and Aqp3) and genes associated …
A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos.
Feofanova EV, Chen H, Dai Y, Jia P, Grove ML, Morrison AC, Qi Q, Daviglus M, Cai J, North KE, Laurie CC, Kaplan RC, Boerwinkle E, Yu B. Feofanova EV, et al. Am J Hum Genet. 2020 Nov 5;107(5):849-863. doi: 10.1016/j.ajhg.2020.09.003. Epub 2020 Oct 7. Am J Hum Genet. 2020. PMID: 33031748 Free PMC article.
We identified co-localization with the expression quantitative trait loci at 105 discovered and 151 known loci-metabolites sets. rs5855544, upstream of SLC51A, was associated with higher levels of three steroid sulfates and co-localized with expression levels of SLC51A …
We identified co-localization with the expression quantitative trait loci at 105 discovered and 151 known loci-metabolites sets. rs5855544, …
Organic solute transporter-β (SLC51B) deficiency in two brothers with congenital diarrhea and features of cholestasis.
Sultan M, Rao A, Elpeleg O, Vaz FM, Abu-Libdeh B, Karpen SJ, Dawson PA. Sultan M, et al. Hepatology. 2018 Aug;68(2):590-598. doi: 10.1002/hep.29516. Epub 2018 May 11. Hepatology. 2018. PMID: 28898457 Free PMC article.
Another major transporter involved in the intestinal reclamation of bile acids is the heteromeric organic solute transporter alpha-beta (OSTalpha-OSTbeta; SLC51A-SLC51B), which exports bile acid across the basolateral membrane. Here we report the first patients with OSTbet …
Another major transporter involved in the intestinal reclamation of bile acids is the heteromeric organic solute transporter alpha-beta (OST …
Organic solute transporter OSTα/β is overexpressed in nonalcoholic steatohepatitis and modulated by drugs associated with liver injury.
Malinen MM, Ali I, Bezençon J, Beaudoin JJ, Brouwer KLR. Malinen MM, et al. Am J Physiol Gastrointest Liver Physiol. 2018 May 1;314(5):G597-G609. doi: 10.1152/ajpgi.00310.2017. Epub 2018 Feb 8. Am J Physiol Gastrointest Liver Physiol. 2018. PMID: 29420067 Free PMC article.
The heteromeric steroid transporter organic solute transporter alpha/beta (OSTalpha/beta, SLC51A/B) was discovered over a decade ago, but its physiological significance in the liver remains uncertain. ...
The heteromeric steroid transporter organic solute transporter alpha/beta (OSTalpha/beta, SLC51A/B) was discovered over a decade ago, …
Selective agonism of liver and gut FXR prevents cholestasis and intestinal atrophy in parenterally fed neonatal pigs.
Jiang Y, Fang Z, Guthrie G, Stoll B, Chacko S, Lin S, Hartmann B, Holst JJ, Dawson H, Pastor JJ, Ipharraguerre IR, Burrin DG. Jiang Y, et al. J Lipid Res. 2025 Nov;66(11):100919. doi: 10.1016/j.jlr.2025.100919. Epub 2025 Oct 1. J Lipid Res. 2025. PMID: 41043692 Free PMC article.
Both CDCA and OCA increased plasma FGF19 and OCA increased intestinal FGF19, FABP6, and SLC51A. Both CDCA and OCA increased intestinal mucosal growth, whereas CDCA increased the plasma GLP-2, GLP-1 and GIP. ...
Both CDCA and OCA increased plasma FGF19 and OCA increased intestinal FGF19, FABP6, and SLC51A. Both CDCA and OCA increased intestina …
35 results