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Ancestry-based differences in the immune phenotype are associated with lupus activity.
Slight-Webb S, Thomas K, Smith M, Wagner CA, Macwana S, Bylinska A, Donato M, Dvorak M, Chang SE, Kuo A, Cheung P, Kalesinskas L, Ganesan A, Dermadi D, Guthridge CJ, DeJager W, Wright C, Foecke MH, Merrill JT, Chakravarty E, Arriens C, Maecker HT, Khatri P, Utz PJ, James JA, Guthridge JM. Slight-Webb S, et al. JCI Insight. 2023 Aug 22;8(16):e169584. doi: 10.1172/jci.insight.169584. JCI Insight. 2023. PMID: 37606045 Free PMC article.
Autoantibody-positive healthy individuals with lower lupus risk display a unique immune endotype.
Slight-Webb S, Smith M, Bylinska A, Macwana S, Guthridge C, Lu R, Merrill JT, Chakravarty E, Arriens C, Munroe ME, Maecker HT, Utz PJ, Guthridge JM, James JA. Slight-Webb S, et al. J Allergy Clin Immunol. 2020 Dec;146(6):1419-1433. doi: 10.1016/j.jaci.2020.04.047. Epub 2020 May 22. J Allergy Clin Immunol. 2020. PMID: 32446964 Free PMC article. Clinical Trial.