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1993 1
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44 results

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Page 1
SLITRK6 promotes the progression of lung adenocarcinoma by regulating PI3K/AKT/mTOR signaling and Warburg effect.
Yu F, Zhao X, Li M, Meng M. Yu F, et al. Apoptosis. 2023 Aug;28(7-8):1216-1225. doi: 10.1007/s10495-023-01838-0. Epub 2023 May 23. Apoptosis. 2023. PMID: 37219677
To investigate the role of SLITRK6 in lung adenocarcinoma (LUAD) and the underlying mechanism in it, clinical tissues and tissue microarray of LUAD were used to detect the expression of SLITRK6. ...SLITRK6 may serve as a potential therapeutic target for LUAD …
To investigate the role of SLITRK6 in lung adenocarcinoma (LUAD) and the underlying mechanism in it, clinical tissues and tissue micr …
The role of SLITRK6 in the pathogenesis of Tourette syndrome: From the conclusion of a family-based study in the Chinese Han population.
Liu W, Zhang X, Deng Z, Li G, Zhang R, Yang Z, Che F, Liu S, Li H. Liu W, et al. J Gene Med. 2020 Jun;22(6):e3173. doi: 10.1002/jgm.3173. Epub 2020 Mar 2. J Gene Med. 2020. PMID: 32037697
Studies in recent years have confirmed the association of SLITRK genes with sensory and neuropsychiatric diseases. To detect whether SLITRK6 is involved in the progress of TS, a family-based association study was performed to explore the possible genetic association betwee …
Studies in recent years have confirmed the association of SLITRK genes with sensory and neuropsychiatric diseases. To detect whether SLIT …
Differential expression of SLITRK6 gene as a potential therapeutic target for urothelial carcinoma in particular upper tract cancer.
Mir MA, Pandith AA, Mansoor S, Baba SM, Makhdoomi R, Ain QU, Anwar I, Para SA, Bhat AH, Koul AM, Manzoor U, Khan I, Beg A, Wani MS. Mir MA, et al. Gene. 2023 Aug 20;878:147583. doi: 10.1016/j.gene.2023.147583. Epub 2023 Jun 22. Gene. 2023. PMID: 37353040

RESULTS: Significantly more than 4-fold high mRNA expression of SLITRK6 was observed in UTUC against 1.2-fold in UBUC (p < 0.0001). The overall SLITRK6 expression by IHC was observed in 80% of the UBUC cases in comparison to 100% strong expression in UTUC patient

…

RESULTS: Significantly more than 4-fold high mRNA expression of SLITRK6 was observed in UTUC against 1.2-fold in UBUC (p < 0.0001)

…
Slitrk6 expression profile in the mouse embryo and its relationship to that of Nlrr3.
Aruga J. Aruga J. Gene Expr Patterns. 2003 Dec;3(6):727-33. doi: 10.1016/s1567-133x(03)00141-8. Gene Expr Patterns. 2003. PMID: 14643680
Here, I show that Slitrk6 is uniquely expressed in various organs, different from other Slitrk genes which are predominantly expressed in neural tissues. ...The expression compartment in the thalamus in which Slitrk6 was expressed was closely related to the Gbx2-exp …
Here, I show that Slitrk6 is uniquely expressed in various organs, different from other Slitrk genes which are predominantly expresse …
SLITRK6 mutations cause myopia and deafness in humans and mice.
Tekin M, Chioza BA, Matsumoto Y, Diaz-Horta O, Cross HE, Duman D, Kokotas H, Moore-Barton HL, Sakoori K, Ota M, Odaka YS, Foster J 2nd, Cengiz FB, Tokgoz-Yilmaz S, Tekeli O, Grigoriadou M, Petersen MB, Sreekantan-Nair A, Gurtz K, Xia XJ, Pandya A, Patton MA, Young JI, Aruga J, Crosby AH. Tekin M, et al. J Clin Invest. 2013 May;123(5):2094-102. doi: 10.1172/JCI65853. Epub 2013 Apr 1. J Clin Invest. 2013. PMID: 23543054 Free PMC article.
High-resolution MRI of WT and Slitrk6-deficient mouse eyes revealed axial length increase in the mutant (the endophenotype of myopia). Additionally, mutant mice exhibited auditory function deficits that mirrored the human phenotype. Histological investigation of WT and …
High-resolution MRI of WT and Slitrk6-deficient mouse eyes revealed axial length increase in the mutant (the endophenotype of myopia) …
Human cytomegalovirus downregulates SLITRK6 expression through IE2.
Liao H, Sato H, Chiba R, Kawai T, Nakabayashi K, Hata K, Akutsu H, Fujiwara S, Nakamura H. Liao H, et al. J Neurovirol. 2017 Feb;23(1):79-86. doi: 10.1007/s13365-016-0475-y. Epub 2016 Aug 16. J Neurovirol. 2017. PMID: 27530937
Congenital human cytomegalovirus (HCMV) infection causes sensorineural hearing loss (SNHL) and other neurological disorders, although the neuropathogenesis of HCMV infection is not well understood. Here, we show that the expression of SLITRK6, one of causative genes for he …
Congenital human cytomegalovirus (HCMV) infection causes sensorineural hearing loss (SNHL) and other neurological disorders, although the ne …
Deafness and Myopia Syndrome.
Ordonez JL, Tekin M. Ordonez JL, et al. 2015 Jan 15 [updated 2017 Sep 14]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. 2015 Jan 15 [updated 2017 Sep 14]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. PMID: 25590127 Free Books & Documents. Review.
Evaluation of relatives at risk: If the SLITRK6 pathogenic variants in the family are known, molecular genetic testing can be used to clarify the genetic status of at-risk sibs. ...Carrier testing for at-risk relatives and prenatal testing for a pregnancy at increased risk …
Evaluation of relatives at risk: If the SLITRK6 pathogenic variants in the family are known, molecular genetic testing can be used to …
Identification of SLITRK6 as a Novel Biomarker in hepatocellular carcinoma by comprehensive bioinformatic analysis.
Liu X, Liu Y, Liu Z, Zhang Y, Ma Y, Bai J, Yao H, Wang Y, Zhao X, Li R, Song X, Chen Y, Feng Z, Wang L. Liu X, et al. Biochem Biophys Rep. 2021 Oct 27;28:101157. doi: 10.1016/j.bbrep.2021.101157. eCollection 2021 Dec. Biochem Biophys Rep. 2021. PMID: 34754951 Free PMC article.
In addition, SLITRK6 was found to be low expressed in tumor cells. To summarize, SLITRK6 mutation was found to significantly affect the occurrence and prognosis of HCC. SLITRK6 was confirmed as a new potential gene target for HCC, which may provide a new theo …
In addition, SLITRK6 was found to be low expressed in tumor cells. To summarize, SLITRK6 mutation was found to significantly a …
Linking transcriptomes with morphological and functional phenotypes in mammalian retinal ganglion cells.
Huang W, Xu Q, Su J, Tang L, Hao ZZ, Xu C, Liu R, Shen Y, Sang X, Xu N, Tie X, Miao Z, Liu X, Xu Y, Liu F, Liu Y, Liu S. Huang W, et al. Cell Rep. 2022 Sep 13;40(11):111322. doi: 10.1016/j.celrep.2022.111322. Cell Rep. 2022. PMID: 36103830 Free article.
We also identify differentially expressed genes among ON, OFF, and ON-OFF RGCs such as Vat1l, Slitrk6, and Lmo7, providing candidate marker genes for functional studies. Our research suggests that the molecularly distinct clusters may also differ in their roles of encoding …
We also identify differentially expressed genes among ON, OFF, and ON-OFF RGCs such as Vat1l, Slitrk6, and Lmo7, providing candidate …
A homozygous SLITRK6 nonsense mutation is associated with progressive auditory neuropathy in humans.
Morlet T, Rabinowitz MR, Looney LR, Riegner T, Greenwood LA, Sherman EA, Achilly N, Zhu A, Yoo E, O'Reilly RC, Jinks RN, Puffenberger EG, Heaps A, Morton H, Strauss KA. Morlet T, et al. Laryngoscope. 2014 Mar;124(3):E95-103. doi: 10.1002/lary.24361. Epub 2013 Dec 17. Laryngoscope. 2014. PMID: 23946138 Free PMC article.
OBJECTIVES/HYPOTHESIS: SLITRK family proteins control neurite outgrowth and regulate synaptic development. In mice, Slitrk6 plays a role in the survival and innervation of sensory neurons in the inner ear, vestibular apparatus, and retina, and also influences axial eye len …
OBJECTIVES/HYPOTHESIS: SLITRK family proteins control neurite outgrowth and regulate synaptic development. In mice, Slitrk6 plays a r …
44 results