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UPF1/SMG7-dependent microRNA-mediated gene regulation.
Park J, Seo JW, Ahn N, Park S, Hwang J, Nam JW. Park J, et al. Nat Commun. 2019 Sep 13;10(1):4181. doi: 10.1038/s41467-019-12123-7. Nat Commun. 2019. PMID: 31519907 Free PMC article.
The destabilization of miRNA targets is accomplished by the combination of Ago2 and UPF1/SMG7, which may recruit the CCR4-NOT deadenylase complex. Indeed, loss of the SMG7-deadenylase complex interaction increases the levels of transcripts regulated by UPF1-SMG7 …
The destabilization of miRNA targets is accomplished by the combination of Ago2 and UPF1/SMG7, which may recruit the CCR4-NOT deadeny …
SMG7-AS1 as a prognostic biomarker and predictor of immunotherapy responses for skin cutaneous melanoma.
Xu X, Ju Y, Zhao X, Yang P, Zhu F, Fang B. Xu X, et al. Genomics. 2023 May;115(3):110614. doi: 10.1016/j.ygeno.2023.110614. Epub 2023 Mar 15. Genomics. 2023. PMID: 36931476 Free article.
In this study, microarray analysis was performed to screen for differentially expressed lncRNAs between SKCM and normal tissues, and SMG7-AS1 was identified as an upregulated lncRNA in SKCM. Subsequently, bioinformatic analysis revealed that dysregulation of SMG7-AS …
In this study, microarray analysis was performed to screen for differentially expressed lncRNAs between SKCM and normal tissues, and SMG7 …
SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity.
Boehm V, Kueckelmann S, Gerbracht JV, Kallabis S, Britto-Borges T, Altmüller J, Krüger M, Dieterich C, Gehring NH. Boehm V, et al. Nat Commun. 2021 Jun 25;12(1):3965. doi: 10.1038/s41467-021-24046-3. Nat Commun. 2021. PMID: 34172724 Free PMC article.
Transcriptome-wide analyses of SMG5-SMG7-depleted cells confirm exhaustive NMD inhibition resulting in massive transcriptomic alterations. Intriguingly, we find that the functionally underestimated SMG5 can substitute the role of SMG7 and individually activate NMD. …
Transcriptome-wide analyses of SMG5-SMG7-depleted cells confirm exhaustive NMD inhibition resulting in massive transcriptomic alterat …
Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress.
Ho K, Luo H, Zhu W, Tang Y. Ho K, et al. Sci Rep. 2021 Apr 5;11(1):7502. doi: 10.1038/s41598-021-86957-x. Sci Rep. 2021. PMID: 33820915 Free PMC article.
CHK1 is a crucial DNA damage checkpoint kinase and its activation, which requires ATR and RAD17, leads to inhibition of DNA replication and cell cycle progression. Recently, we reported that SMG7 stabilizes and activates p53 to induce G(1) arrest upon DNA damage; here we s …
CHK1 is a crucial DNA damage checkpoint kinase and its activation, which requires ATR and RAD17, leads to inhibition of DNA replication and …
Characterization of SMG7 14-3-3-like domain reveals phosphoserine binding-independent regulation of p53 and UPF1.
Cowen LE, Luo H, Tang Y. Cowen LE, et al. Sci Rep. 2019 Sep 11;9(1):13097. doi: 10.1038/s41598-019-49229-3. Sci Rep. 2019. PMID: 31511540 Free PMC article.
The 14-3-3-related protein SMG7 plays critical roles in regulation of DNA damage response and nonsense-mediated mRNA decay (NMD). Like 14-3-3, SMG7 engages phosphoserine-dependent protein interactions; however, the precise role of phosphorylation-mediated SMG7 …
The 14-3-3-related protein SMG7 plays critical roles in regulation of DNA damage response and nonsense-mediated mRNA decay (NMD). Lik …
SNPs at SMG7 Associated with Time from Biochemical Recurrence to Prostate Cancer Death.
Song X, Ru M, Steinsnyder Z, Tkachuk K, Kopp RP, Sullivan J, Gümüş ZH, Offit K, Joseph V, Klein RJ. Song X, et al. Cancer Epidemiol Biomarkers Prev. 2022 Jul 1;31(7):1466-1472. doi: 10.1158/1055-9965.EPI-22-0053. Cancer Epidemiol Biomarkers Prev. 2022. PMID: 35511739 Free PMC article.
SNP rs2702185 was further tested for association with time to biochemical recurrence and time from biochemical recurrence to death with a multi-state model. RESULTS: SNP rs2702185 at SMG7 was associated with prostate cancer-specific survival time, specifically the time fro …
SNP rs2702185 was further tested for association with time to biochemical recurrence and time from biochemical recurrence to death with a mu …
Nonsense-mediated decay factor SMG7 sensitizes cells to TNFalpha-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1.
Yang L, Kraft VAN, Pfeiffer S, Merl-Pham J, Bao X, An Y, Hauck SM, Schick JA. Yang L, et al. Mol Oncol. 2020 Oct;14(10):2420-2435. doi: 10.1002/1878-0261.12754. Epub 2020 Jul 13. Mol Oncol. 2020. PMID: 32602581 Free PMC article.
In this study, we show that loss of Smg7 leads to unrestricted expression of long noncoding RNAs (lncRNAs) in addition to NMD targets. ...The data highlight a novel and specific regulation of oncogenic factors by SMG7 and pinpoint a composite tumor suppressor role i …
In this study, we show that loss of Smg7 leads to unrestricted expression of long noncoding RNAs (lncRNAs) in addition to NMD targets …
SMG7 acts as a molecular link between mRNA surveillance and mRNA decay.
Unterholzner L, Izaurralde E. Unterholzner L, et al. Mol Cell. 2004 Nov 19;16(4):587-96. doi: 10.1016/j.molcel.2004.10.013. Mol Cell. 2004. PMID: 15546618 Free article.
Here we show that SMG5 and SMG7 colocalize in cytoplasmic mRNA decay bodies, while SMG6 forms separate cytoplasmic foci. ...This activity is mediated by the C-terminal domain of SMG7. In contrast, SMG5 requires SMG7 to trigger mRNA decay and to localize to de …
Here we show that SMG5 and SMG7 colocalize in cytoplasmic mRNA decay bodies, while SMG6 forms separate cytoplasmic foci. ...This acti …
Functional Characterization of SMG7 Paralogs in Arabidopsis thaliana.
Capitao C, Shukla N, Wandrolova A, Mittelsten Scheid O, Riha K. Capitao C, et al. Front Plant Sci. 2018 Nov 6;9:1602. doi: 10.3389/fpls.2018.01602. eCollection 2018. Front Plant Sci. 2018. PMID: 30459790 Free PMC article.
Here we characterized SMG7 and SMG7-like (SMG7L) paralogs in Arabidopsis thaliana. SMG7 retained its role in NMD and additionally appears to have acquired another function in meiosis. We inactivated SMG7 by CRISPR/Cas9 mutagenesis and showed that, in c …
Here we characterized SMG7 and SMG7-like (SMG7L) paralogs in Arabidopsis thaliana. SMG7 retained its role in NMD and ad …
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway.
Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E. Fukuhara N, et al. Mol Cell. 2005 Feb 18;17(4):537-47. doi: 10.1016/j.molcel.2005.01.010. Mol Cell. 2005. PMID: 15721257 Free article.
UPF1 is targeted for dephosphorylation by three related proteins, SMG5, SMG6, and SMG7. We report here the crystal structure of the N-terminal domain of SMG7. The structure reveals that SMG7 contains a 14-3-3-like domain. Residues that bind phosphoserine-cont …
UPF1 is targeted for dephosphorylation by three related proteins, SMG5, SMG6, and SMG7. We report here the crystal structure of the N …
94 results