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117 results

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Page 1
Mutations in the spliceosomal gene SNW1 cause neurodevelopment disorders with microcephaly.
Ji L, Yan J, Losurdo NA, Wang H, Liu L, Li K, Liu Z, Guo Z, Xu J, Bibo A, Ren D, Yang K, Luo Y, Yang F, Wang G, Xiang Z, Wang Y, Zhan H, Pan H, Hu J, Zhong J, Abou Jamra R, Zacher P, Musante L, Faletra F, Costa P, Zanus C, Couque N, Ruaud L, Cueto-González AM, San Nicolas Fernández H, Tizzano E, Martinez Gil N, Liu X, Liao W, Abi Farraj L, Huang AY, Zhang L, Murali A, Schmuel E, Han CS, King K, Gu W, Wang P, Li K, Link N, He G, Bian S, Mao X. Ji L, et al. J Clin Invest. 2025 Jul 3;135(18):e186119. doi: 10.1172/JCI186119. eCollection 2025 Sep 16. J Clin Invest. 2025. PMID: 40608414 Free PMC article.
Here, we investigated the role of SNW domain-containing protein 1 (SNW1), a spliceosomal protein, in splicing integrity and neurodevelopment. We identified 9 heterozygous mutations in the SNW1 gene in patients presenting with primary microcephaly. These mutations im …
Here, we investigated the role of SNW domain-containing protein 1 (SNW1), a spliceosomal protein, in splicing integrity and neurodeve …
Antrodia cinnamomea triterpenoids attenuate cardiac hypertrophy via the SNW1/RXR/ALDH2 axis.
Ma Y, Wang Y, Anwaier G, Tuerdi N, Wu Y, Huang Y, Qin B, Ma H, Zhang Q, Wu D, Zeng K, Qi R. Ma Y, et al. Redox Biol. 2024 Dec;78:103437. doi: 10.1016/j.redox.2024.103437. Epub 2024 Nov 19. Redox Biol. 2024. PMID: 39591904 Free PMC article.
Furthermore, it inhibited oxidative stress and improved mitochondrial quality control (MQC) homeostasis in an ALDH2-dependent manner. We screened SNW1, a transcriptional coactivator, as a DSA-binding protein by "target fishing" and cellular enthusiasm transfer assay techni …
Furthermore, it inhibited oxidative stress and improved mitochondrial quality control (MQC) homeostasis in an ALDH2-dependent manner. We scr …
SNW1 is a prognostic biomarker in prostate cancer.
Höflmayer D, Willich C, Hube-Magg C, Simon R, Lang D, Neubauer E, Jacobsen F, Hinsch A, Luebke AM, Tsourlakis MC, Huland H, Graefen M, Haese A, Heinzer H, Minner S, Büscheck F, Sauter G, Schlomm T, Steurer S, Clauditz TS, Burandt E, Wilczak W, Bernreuther C. Höflmayer D, et al. Diagn Pathol. 2019 May 1;14(1):33. doi: 10.1186/s13000-019-0810-8. Diagn Pathol. 2019. PMID: 31043167 Free PMC article.
Overexpression of SNW1 has been linked to adverse prognosis in different cancer types, but studies on the role of SNW1 in prostate cancer are lacking. ...RESULTS: The comparison with normal prostate tissue revealed an up regulation of SNW1 in a subset of canc …
Overexpression of SNW1 has been linked to adverse prognosis in different cancer types, but studies on the role of SNW1 in pros …
SNW1 regulates Notch signaling in neuroblastoma through interacting with RBPJ.
Hong M, He J, Li S. Hong M, et al. Biochem Biophys Res Commun. 2019 Feb 19;509(4):869-876. doi: 10.1016/j.bbrc.2019.01.036. Epub 2019 Jan 12. Biochem Biophys Res Commun. 2019. PMID: 30642633
In this study, we show that SNW domain containing 1 (SNW1) acts as a novel RBPJ partner and regulates the expression of Notch target genes. Additionally, we show that silencing RBPJ expression can prevent SNW1-mediated Notch gene expression. Public datasets and clin …
In this study, we show that SNW domain containing 1 (SNW1) acts as a novel RBPJ partner and regulates the expression of Notch target …
SNW1, a Novel Transcriptional Regulator of the NF-kappaB Pathway.
Verma S, De Jesus P, Chanda SK, Verma IM. Verma S, et al. Mol Cell Biol. 2019 Jan 16;39(3):e00415-18. doi: 10.1128/MCB.00415-18. Print 2019 Feb 1. Mol Cell Biol. 2019. PMID: 30397075 Free PMC article.
We show that SNW1 detaches from its splicing complex (formed with SNRNP200 and SNRNP220) upon NF-kappaB activation and binds to NF-kappaB's transcriptional elongation partner p-TEFb. We also show that SNW1 is indispensable for the transcriptional elongation of NF-ka …
We show that SNW1 detaches from its splicing complex (formed with SNRNP200 and SNRNP220) upon NF-kappaB activation and binds to NF-ka …
SNW1 interacts with IKKgamma to positively regulate antiviral innate immune responses against influenza A virus infection.
Zhang Q, Liang T, Gu S, Ye Y, Liu S. Zhang Q, et al. Microbes Infect. 2020 Nov-Dec;22(10):576-584. doi: 10.1016/j.micinf.2020.07.009. Epub 2020 Aug 14. Microbes Infect. 2020. PMID: 32805409 Free article.
Here, for the first time, we demonstrated that SNW1 positively regulates the expression of pro-inflammatory cytokines and interferon (IFN) responses induced by influenza A virus (IAV) infection, and further inhibits virus replication by performing SNW1 depletion or …
Here, for the first time, we demonstrated that SNW1 positively regulates the expression of pro-inflammatory cytokines and interferon …
SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.
van der Lelij P, Stocsits RR, Ladurner R, Petzold G, Kreidl E, Koch B, Schmitz J, Neumann B, Ellenberg J, Peters JM. van der Lelij P, et al. EMBO J. 2014 Nov 18;33(22):2643-58. doi: 10.15252/embj.201488202. Epub 2014 Sep 25. EMBO J. 2014. PMID: 25257309 Free PMC article.
SNW1 depletion causes cohesion defects predominantly by reducing sororin levels, which causes destabilisation of cohesin on DNA. SNW1 depletion also reduces APC/C activity and contributes to cohesion defects indirectly by delaying mitosis and causing "cohesion fatig …
SNW1 depletion causes cohesion defects predominantly by reducing sororin levels, which causes destabilisation of cohesin on DNA. S …
Dexmedetomidine Inhibits NF-kappaB-Transcriptional Activity in Neurons Undergoing Ischemia-Reperfusion by Regulating O-GlcNAcylation of SNW1.
She C, Zhu J, Liu A, Xu Y, Jiang Z, Peng Y. She C, et al. J Neuropathol Exp Neurol. 2022 Sep 19;81(10):836-849. doi: 10.1093/jnen/nlac055. J Neuropathol Exp Neurol. 2022. PMID: 35818332
SH-SY5Y and PC12 cells under hypoxia/reoxygenation (H/R) conditions were treated with Dex and with inhibitors of O-GlcNAc transferase (OGT). O-GlcNAc levels in SNW1 and effects of SNW1 on NF-kappaB p65 were determined by immunoprecipitation. H/R increased SNW1 …
SH-SY5Y and PC12 cells under hypoxia/reoxygenation (H/R) conditions were treated with Dex and with inhibitors of O-GlcNAc transferase (OGT). …
SNW1 promotes lymphatic metastasis in bladder cancer by modulating SRPK1 splicing.
Hu J, Zhu Y, Wang G, Dai H, Han H, Cao W, Ding M, Diao W, Lu Q, Zhang Q, Guo H, Chen W. Hu J, et al. iScience. 2026 Jan 27;29(2):114811. doi: 10.1016/j.isci.2026.114811. eCollection 2026 Feb 20. iScience. 2026. PMID: 41704767 Free PMC article.
This study identified that elevated levels of SNW1 have been correlated with LN metastasis and unfavorable patient outcomes. SNW1 enhances the migratory and invasive capabilities of BCa cells. ...The effect of SNW1 on promoting metastasis is dependent on SRPK …
This study identified that elevated levels of SNW1 have been correlated with LN metastasis and unfavorable patient outcomes. SNW1 …
Phosphorylation of SNW1 protein associated with equine melanocytic neoplasm identified in serum and feces.
Vinijkumthorn R, Kingkaw A, Yanyongsirikarn P, Phaonakrop N, Roytrakul S, Vongsangnak W, Tesena P. Vinijkumthorn R, et al. Sci Rep. 2024 Dec 28;14(1):30842. doi: 10.1038/s41598-024-81338-6. Sci Rep. 2024. PMID: 39730520 Free PMC article.
Notably, the integrin NF-kappaB binding P-TEFb to stimulate transcriptional elongation signaling pathway, involving SNW1 protein, was implicated in early stage of EMN development in both serum and fecal samples. This highlights SNW1's potential role in mediating tra …
Notably, the integrin NF-kappaB binding P-TEFb to stimulate transcriptional elongation signaling pathway, involving SNW1 protein, was …
117 results