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170 results

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Page 1
Endosomal Sorting Protein SNX27 and Its Emerging Roles in Human Cancers.
Deb S, Sun J. Deb S, et al. Cancers (Basel). 2022 Dec 22;15(1):70. doi: 10.3390/cancers15010070. Cancers (Basel). 2022. PMID: 36612066 Free PMC article. Review.
Over 100 cell surface proteins have been identified as binding partners of the SNX27-retromer complex. However, the roles and underlying mechanisms governed by SNX27 in tumorigenesis remains to be poorly understood. ...In this review, we summarize the structure and …
Over 100 cell surface proteins have been identified as binding partners of the SNX27-retromer complex. However, the roles and underly …
Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease.
Chandra M, Kendall AK, Jackson LP. Chandra M, et al. Front Cell Dev Biol. 2021 Apr 15;9:642378. doi: 10.3389/fcell.2021.642378. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33937239 Free PMC article. Review.
Thus, the correct sorting of multiple receptors by SNX27/retromer is vital for normal cellular function to prevent human diseases. The role of SNX27 in regulating cargo recycling from endosomes to the cell surface is firmly established, but how SNX27 assemble …
Thus, the correct sorting of multiple receptors by SNX27/retromer is vital for normal cellular function to prevent human diseases. Th …
SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry.
Yang B, Jia Y, Meng Y, Xue Y, Liu K, Li Y, Liu S, Li X, Cui K, Shang L, Cheng T, Zhang Z, Hou Y, Yang X, Yan H, Duan L, Tong Z, Wu C, Liu Z, Gao S, Zhuo S, Huang W, Gao GF, Qi J, Shang G. Yang B, et al. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2117576119. doi: 10.1073/pnas.2117576119. Proc Natl Acad Sci U S A. 2022. PMID: 35022217 Free PMC article.
Recent studies show ACE2 possesses a type I PDZ binding motif (PBM) through which it could interact with a PDZ domain-containing protein such as sorting nexin 27 (SNX27). In this study, we determined the ACE2-PBM/SNX27-PDZ complex structure, and, through a series of …
Recent studies show ACE2 possesses a type I PDZ binding motif (PBM) through which it could interact with a PDZ domain-containing protein suc …
Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS.
González-Mancha N, Mérida I. González-Mancha N, et al. Int J Mol Sci. 2020 Jun 15;21(12):4254. doi: 10.3390/ijms21124254. Int J Mol Sci. 2020. PMID: 32549284 Free PMC article. Review.
Among the multiple players involved in this polarized intracellular trafficking, we find sorting nexin 27 (SNX27). This protein translocates to the T cell-APC interface upon TCR activation, and it is suggested to facilitate the transport of cargoes toward this structure. F …
Among the multiple players involved in this polarized intracellular trafficking, we find sorting nexin 27 (SNX27). This protein trans …
Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression.
Zheng C, Liang J, Yu S, Xu H, Dai L, Xu D. Zheng C, et al. Korean J Physiol Pharmacol. 2023 Jul 1;27(4):333-344. doi: 10.4196/kjpp.2023.27.4.333. Korean J Physiol Pharmacol. 2023. PMID: 37386831 Free PMC article.
Moreover, the poor levels of circ-SNX27 inhibited HCC tumor growth among the mice. Circ-SNX27 enhanced RPN1 by competitively binding with miR-375. ...This is indicative of circ-SNX27's potential as a target for the treatment of HCC....
Moreover, the poor levels of circ-SNX27 inhibited HCC tumor growth among the mice. Circ-SNX27 enhanced RPN1 by competitively b …
SNX27: A trans-species cognitive modulator with implications for anxiety and stress susceptibility.
Armada G, Roque S, Serre-Miranda C, Ferreira L, Vale A, Rodrigues AJ, Hong W, Correia-Neves M, Vieira N. Armada G, et al. Neurobiol Stress. 2024 Mar 5;30:100619. doi: 10.1016/j.ynstr.2024.100619. eCollection 2024 May. Neurobiol Stress. 2024. PMID: 38500791 Free PMC article.
Despite this, SNX27's role in the nervous system remains poorly explored. To further understand SNX27 function, we performed an extensive behavioral characterization comprising motor, cognitive and emotional dimensions of SNX27(+/-) mice. ...SNX27(+/-) …
Despite this, SNX27's role in the nervous system remains poorly explored. To further understand SNX27 function, we performed a …
Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex.
Guo Q, Chen KE, Gimenez-Andres M, Jellett AP, Gao Y, Simonetti B, Liu M, Danson CM, Heesom KJ, Cullen PJ, Collins BM. Guo Q, et al. Proc Natl Acad Sci U S A. 2024 Aug 13;121(33):e2405041121. doi: 10.1073/pnas.2405041121. Epub 2024 Aug 8. Proc Natl Acad Sci U S A. 2024. PMID: 39116126 Free PMC article.
The Retromer complex coordinates with sorting nexin (SNX) cargo adaptors including SNX27, and the SNX27-Retromer assembly interacts with the Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex which nucleates actin filaments establishing the endosomal r …
The Retromer complex coordinates with sorting nexin (SNX) cargo adaptors including SNX27, and the SNX27-Retromer assembly inte …
Circ_SNX27 regulates hepatocellular carcinoma development via miR-637/FGFR1 axis.
Li H, Liu B, Xu X, Li S, Zhang D, Liu Q. Li H, et al. Environ Toxicol. 2022 Dec;37(12):2832-2843. doi: 10.1002/tox.23640. Epub 2022 Aug 27. Environ Toxicol. 2022. PMID: 36029209
The relationship between miR-637 with circ_SNX27 or FGFR1 was uncovered by dual-luciferase reporter and RNA pull-down assays. RESULTS: The circ_SNX27 and FGFR1 levels were up-regulated, but miR-637 content was reduced in HCC. ...Circ_SNX27 served as a sponge …
The relationship between miR-637 with circ_SNX27 or FGFR1 was uncovered by dual-luciferase reporter and RNA pull-down assays. RESULTS …
VARP binds SNX27 to promote endosomal supercomplex formation on membranes.
Chandra M, Kendall AK, Ford MGJ, Jackson LP. Chandra M, et al. Sci Adv. 2025 Feb 14;11(7):eadr9340. doi: 10.1126/sciadv.adr9340. Epub 2025 Feb 12. Sci Adv. 2025. PMID: 39937906 Free PMC article.
We demonstrate and measure how specific combinations of Retromer with SNX27, ESCPE-1 (SNX2/SNX6), or both complexes, remodel membranes containing physiological cargo and phospholipids. SNX27, alone and with Retromer, remodels membranes with PI(3)P and PDZbm cargo. E …
We demonstrate and measure how specific combinations of Retromer with SNX27, ESCPE-1 (SNX2/SNX6), or both complexes, remodel membrane …
SNX27:Retromer:ESCPE-1-mediated early endosomal tubulation impacts cytomegalovirus replication.
Štimac I, Marcelić M, Radić B, Viduka I, Blagojević Zagorac G, Lukanović Jurić S, Rožmanić C, Messerle M, Brizić I, Lučin P, Mahmutefendić Lučin H. Štimac I, et al. Front Cell Infect Microbiol. 2024 Sep 18;14:1399761. doi: 10.3389/fcimb.2024.1399761. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 39359939 Free PMC article.
RESULTS: Here we show that SNX27:Retromer:ESCPE1-mediated tubulation is essential for the establishment of a Rab10-decorated subset of membranes within the pre-AC, a function that requires an intact F3 subdomain of the SNX27 FERM domain. Suppression of SNX27- …
RESULTS: Here we show that SNX27:Retromer:ESCPE1-mediated tubulation is essential for the establishment of a Rab10-decorated subset o …
170 results