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Page 1
The Neglected Suppressor of Cytokine Signalling (SOCS): SOCS4-7.
Herrera-Uribe J, Convery O, ALmohammadi D, Weinberg FI, Stevenson NJ. Herrera-Uribe J, et al. Inflammation. 2025 Aug;48(4):1607-1623. doi: 10.1007/s10753-024-02163-7. Epub 2024 Oct 26. Inflammation. 2025. PMID: 39460806 Review.
While the mechanisms of action of CIS, SOCS1-3 are well-documented, information regarding SOCS4-7 remains limited. However, recent studies have begun to elucidate the regulatory functions of these proteins during infection and disease, such as influenza infection, cancer a …
While the mechanisms of action of CIS, SOCS1-3 are well-documented, information regarding SOCS4-7 remains limited. However, recent st …
SOCS4 expressed by recombinant HSV protects against cytokine storm in a mouse model.
Ren S, Chen X, Huang R, Zhou GG, Yuan Z. Ren S, et al. Oncol Rep. 2019 Mar;41(3):1509-1520. doi: 10.3892/or.2018.6935. Epub 2018 Dec 18. Oncol Rep. 2019. PMID: 30569160 Free PMC article.
HSV-SOCS4-infected mice exhibited slight lung damage, a decrease in body weight loss and a 100% survival rate. The results of the present study indicated that SOCS4 protein may be a useful regulator to inhibit cytokine overproduction, and that HSV-SOCS4 may p …
HSV-SOCS4-infected mice exhibited slight lung damage, a decrease in body weight loss and a 100% survival rate. The results of the pre …
Up-regulation of SOCS4 promotes cell proliferation and migration in esophageal squamous cell carcinoma.
Ying J, Huang HH, Zhang MM, Chen JF. Ying J, et al. Transl Cancer Res. 2021 May;10(5):2416-2427. doi: 10.21037/tcr-21-700. Transl Cancer Res. 2021. PMID: 35116557 Free PMC article.
While, the expression and the roles of SOCS4 in esophageal squamous cell carcinoma (ESCC) remain elusive. The current study is aimed to investigate the expression pattern and functions of SOCS4 in ESCC. ...Inhibition of SOCS4 may be a promising therapeutic st …
While, the expression and the roles of SOCS4 in esophageal squamous cell carcinoma (ESCC) remain elusive. The current study is aimed …
The miR-876-5p/SOCS4/STAT3 pathway induced the expression of PD-L1 and suppressed antitumor immune responses.
Peng HY, Huang YL, Wu PH, Li LJ, Peng BY, Wu CY, Lin YL, Hsiao M, Chang JY, Mu-Hsin Chang P, Lee HL, Chang WM. Peng HY, et al. Cancer Cell Int. 2025 Mar 26;25(1):114. doi: 10.1186/s12935-025-03704-2. Cancer Cell Int. 2025. PMID: 40140827 Free PMC article.
Mechanistically, miR-876-5p directly targets SOCS4, leading to increased STAT3 activation and subsequent upregulation of PD-L1, which facilitates immune evasion. Additionally, exposure to the tobacco-specific carcinogen NNK was found to induce miR-876 expression and STAT3 …
Mechanistically, miR-876-5p directly targets SOCS4, leading to increased STAT3 activation and subsequent upregulation of PD-L1, which …
miR-1915-3p regulates megakaryocytic and erythroid differentiation by targeting SOCS4.
Yuan X, Liu P, Xu L, Liang L, Dong Q, Fan T, Yue W, Qu M, Pei X, Xie X. Yuan X, et al. Thromb J. 2024 Aug 9;22(1):74. doi: 10.1186/s12959-024-00615-6. Thromb J. 2024. PMID: 39123189 Free PMC article.
Accordingly, we scanned for miR-1915-3p target genes and confirmed that SOCS4 is one of the direct targets of miR-1915-3p. An attentive examination of the endogenous expression of SOCS4 during megakaryocytic and erythroid differentiation suggested the involvement of …
Accordingly, we scanned for miR-1915-3p target genes and confirmed that SOCS4 is one of the direct targets of miR-1915-3p. An attenti …
SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity.
Kedzierski L, Clemens EB, Bird NL, Kile BT, Belz GT, Nicola NA, Kedzierska K, Nicholson SE. Kedzierski L, et al. Immunol Cell Biol. 2015 Nov;93(10):909-13. doi: 10.1038/icb.2015.55. Epub 2015 Jun 16. Immunol Cell Biol. 2015. PMID: 26077508
Therefore, we postulated that SOCS4 is a critical regulator of anti-viral immunity. Unexpectedly, SOCS4 was not required for CD8(+) T-cell memory generation, nor was it required to efficiently recall those cells in response to secondary IAV infection. ...Our data sh …
Therefore, we postulated that SOCS4 is a critical regulator of anti-viral immunity. Unexpectedly, SOCS4 was not required for C …
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.
Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CP, Bose R, Travaglini KJ, Lam VL, Goodness D, Dixon G, Marzette E, Jin J, Tian R, Tse E, Abskharon R, Pan H, Carroll EC, Lawrence RE, Gestwicki JE, Eisenberg D, Kanaan NM, Southworth DR, Gross JD, Gan L, Swaney DL, Kampmann M. Samelson AJ, et al. bioRxiv [Preprint]. 2024 Nov 4:2023.06.16.545386. doi: 10.1101/2023.06.16.545386. bioRxiv. 2024. PMID: 37398204 Free PMC article. Preprint.
We discover that the E3 ubiquitin ligase CUL5(SOCS4) is a potent modifier of tau levels in human neurons, ubiquitinates tau, and is a correlated with vulnerability to tauopathies in mouse and human. ...
We discover that the E3 ubiquitin ligase CUL5(SOCS4) is a potent modifier of tau levels in human neurons, ubiquitinates tau, and is a …
In Semliki Forest virus encephalitis, suppressor of cytokine signaling 4 (SOCS4) is an essential modulator of immune responses that mediates the balance between immunopathology and virus clearance.
Kedzierski L, Er Qi Tan A, Jia Hui Foo I, Narayanan D, Moily N, McQuilten HA, Nicholson SE, Fazakerley JK. Kedzierski L, et al. Immunol Cell Biol. 2023 Apr;101(4):333-344. doi: 10.1111/imcb.12625. Epub 2023 Feb 14. Immunol Cell Biol. 2023. PMID: 36702633
Using a mouse model system, we demonstrate that lack of SOCS4 results in changes in the pathogenesis and clinical outcome of a neurotropic virus infection. ...We conclude that, in the mouse brain, SOCS4 is a vital regulator of antiviral immunity that mediates the cr …
Using a mouse model system, we demonstrate that lack of SOCS4 results in changes in the pathogenesis and clinical outcome of a neurot …
lncRNA ZNF674-AS1 inhibits the migration, invasion and epithelial-mesenchymal transition of thyroid cancer cells by modulating the miR-181a/SOCS4 axis.
Le F, Li HM, Lv QL, Chen JJ, Lin QX, Ji YL, Yi B. Le F, et al. Mol Cell Endocrinol. 2022 Mar 15;544:111551. doi: 10.1016/j.mce.2021.111551. Epub 2022 Jan 4. Mol Cell Endocrinol. 2022. PMID: 34990740
Cell proliferation, migration and invasion were detected using MTT and Transwell assays. ZNF674-AS1 and SOCS4 expression were remarkably reduced while miR-181a was upregulated in TC tissues and cells. ...Mechanistic assays verified that ZNF674-AS1 directly interacted with …
Cell proliferation, migration and invasion were detected using MTT and Transwell assays. ZNF674-AS1 and SOCS4 expression were remarka …
lncRNA-LET Regulates Glycolysis and Glutamine Decomposition of Esophageal Squamous Cell Carcinoma Through miR-93-5p/miR-106b-5p/SOCS4.
Su X, Xue C, Xie C, Si X, Xu J, Huang W, Huang Z, Lin J, Chen Z. Su X, et al. Front Oncol. 2022 May 10;12:897751. doi: 10.3389/fonc.2022.897751. eCollection 2022. Front Oncol. 2022. PMID: 35619921 Free PMC article.
Finally, the mechanistic views regarding the effects of miR-106b-5p or miR-93-5p and SOCS4 on ESCC are related to the feedback of lncRNA-LET. CONCLUSION: Collectively, this study suggested that lncRNA-LET miR-93-5p or the miR-106b-5p-SOCS4 axis may provide great pot …
Finally, the mechanistic views regarding the effects of miR-106b-5p or miR-93-5p and SOCS4 on ESCC are related to the feedback of lnc …
99 results