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1990 1
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2002 2
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2007 2
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The following term was not found in PubMed: nooraee-motlagh
Page 1
Efficacy and Safety of Mirvetuximab Soravtansine in Patients With Platinum-Resistant Ovarian Cancer With High Folate Receptor Alpha Expression: Results From the SORAYA Study.
Matulonis UA, Lorusso D, Oaknin A, Pignata S, Dean A, Denys H, Colombo N, Van Gorp T, Konner JA, Marin MR, Harter P, Murphy CG, Wang J, Noble E, Esteves B, Method M, Coleman RL. Matulonis UA, et al. J Clin Oncol. 2023 May 1;41(13):2436-2445. doi: 10.1200/JCO.22.01900. Epub 2023 Jan 30. J Clin Oncol. 2023. PMID: 36716407 Free PMC article. Clinical Trial.
Mirvetuximab soravtansine (MIRV) is an antibody-drug conjugate targeting folate receptor alpha (FRalpha). SORAYA is a single-arm, phase II study evaluating efficacy and safety of MIRV in patients with PROC. METHODS: SORAYA enrolled FRalpha-high patients with PROC wh …
Mirvetuximab soravtansine (MIRV) is an antibody-drug conjugate targeting folate receptor alpha (FRalpha). SORAYA is a single-arm, pha …
Antibody-Drug Conjugates in Gynecologic Cancer.
Karpel HC, Powell SS, Pothuri B. Karpel HC, et al. Am Soc Clin Oncol Educ Book. 2023 May;43:e390772. doi: 10.1200/EDBK_390772. Am Soc Clin Oncol Educ Book. 2023. PMID: 37229642 Free article. Review.
In ovarian cancer, mirvetuximab soravtansine, an ADC targeting alpha-folate receptor (FRalpha), received US Food and Drug Administration (FDA) accelerated approval in November 2022 after data from the single-arm phase III SORAYA trial. A second ADC targeting FRalpha, STRO- …
In ovarian cancer, mirvetuximab soravtansine, an ADC targeting alpha-folate receptor (FRalpha), received US Food and Drug Administration (FD …
Antibody-Drug Conjugates in Gynecologic Cancers.
Anastasio MK, Shuey S, Davidson BA. Anastasio MK, et al. Curr Treat Options Oncol. 2024 Jan;25(1):1-19. doi: 10.1007/s11864-023-01166-0. Epub 2024 Jan 3. Curr Treat Options Oncol. 2024. PMID: 38172449 Review.
Mirvetuximab soravtansine targets folate receptor alpha and is approved for use in patients with folate receptor alpha-positive, platinum-resistant, epithelial ovarian cancer based on results from the SORAYA trial. While there are no FDA-approved ADCs for the treatment of …
Mirvetuximab soravtansine targets folate receptor alpha and is approved for use in patients with folate receptor alpha-positive, platinum-re …
FDA Approval Summary: Mirvetuximab Soravtansine-Gynx for FRα-Positive, Platinum-Resistant Ovarian Cancer.
Dilawari A, Shah M, Ison G, Gittleman H, Fiero MH, Shah A, Hamed SS, Qiu J, Yu J, Manheng W, Ricks TK, Pragani R, Arudchandran A, Patel P, Zaman S, Roy A, Kalavar S, Ghosh S, Pierce WF, Rahman NA, Tang S, Mixter BD, Kluetz PG, Pazdur R, Amiri-Kordestani L. Dilawari A, et al. Clin Cancer Res. 2023 Oct 2;29(19):3835-3840. doi: 10.1158/1078-0432.CCR-23-0991. Clin Cancer Res. 2023. PMID: 37212825 Free PMC article.
The VENTANA FOLR1 (FOLR-2.1) RxDx Assay was approved as a companion diagnostic device to select patients for this indication. Approval was based on Study 0417 (SORAYA, NCT04296890), a single-arm, multicenter trial. In 104 patients with measurable disease who received mirve …
The VENTANA FOLR1 (FOLR-2.1) RxDx Assay was approved as a companion diagnostic device to select patients for this indication. Approval was b …
International Epidemiology of Carbapenemase-Producing Escherichia coli.
Boutzoukas AE, Komarow L, Chen L, Hanson B, Kanj SS, Liu Z, Salcedo Mendoza S, Ordoñez K, Wang M, Paterson DL, Evans S, Ge L, Giri A, Hill C, Baum K, Bonomo RA, Kreiswirth B, Patel R, Arias CA, Chambers HF, Fowler VG, van Duin D; Multi-Drug Resistant Organism Network Investigators. Boutzoukas AE, et al. Clin Infect Dis. 2023 Aug 22;77(4):499-509. doi: 10.1093/cid/ciad288. Clin Infect Dis. 2023. PMID: 37154071 Free PMC article.
Strategies for prevention and management of ocular events occurring with mirvetuximab soravtansine.
Hendershot A, Slabaugh M, Riaz KM, Moore KN, O'Malley DM, Matulonis U, Konecny GE. Hendershot A, et al. Gynecol Oncol Rep. 2023 Feb 28;47:101155. doi: 10.1016/j.gore.2023.101155. eCollection 2023 Jun. Gynecol Oncol Rep. 2023. PMID: 37102083 Free PMC article. Review.
Pooled safety analysis of 464 MIRV-treated patients across 3 trials, including the phase 2 SORAYA study, found that 50% of patients had 1 ocular AEs of interest (AEIs) of blurred vision or keratopathy, the majority being grade 2. ...
Pooled safety analysis of 464 MIRV-treated patients across 3 trials, including the phase 2 SORAYA study, found that 50% of patients h …
Niacin.
Djadjo S, Bajaj T. Djadjo S, et al. 2023 Mar 20. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Mar 20. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31082080 Free Books & Documents.
Dendrimer Prodrugs.
da Silva Santos S, Igne Ferreira E, Giarolla J. da Silva Santos S, et al. Molecules. 2016 May 31;21(6):686. doi: 10.3390/molecules21060686. Molecules. 2016. PMID: 27258239 Free PMC article. Review.
Mirvetuximab soravtansine-gynx: first antibody/antigen-drug conjugate (ADC) in advanced or recurrent ovarian cancer.
Bogani G, Coleman RL, Vergote I, van Gorp T, Ray-Coquard I, Oaknin A, Matulonis U, O'Malley D, Raspagliesi F, Scambia G, Monk BJ. Bogani G, et al. Int J Gynecol Cancer. 2024 Apr 1;34(4):469-477. doi: 10.1136/ijgc-2023-004924. Int J Gynecol Cancer. 2024. PMID: 38101816 Review.
On the basis of the data reported from this latter study, MIRV was then explored in the FRalpha-high population only and using a different folate receptor assay. The phase II SORAYA trial supported the adoption of MIRV in this setting. Hence, the US Food and Drug Administr …
On the basis of the data reported from this latter study, MIRV was then explored in the FRalpha-high population only and using a different f …
Mirvetuximab soravtansine for platinum-resistant epithelial ovarian cancer.
Porter RL, Matulonis UA. Porter RL, et al. Expert Rev Anticancer Ther. 2023 Jul-Dec;23(8):783-796. doi: 10.1080/14737140.2023.2236793. Epub 2023 Jul 24. Expert Rev Anticancer Ther. 2023. PMID: 37458180 Review.
Mirvetuximab received accelerated approval by the United States Food and Drug Administration (FDA) in November 2022 based on the results of the SORAYA trial, which tested mirvetuximab for the treatment of patients with recurrent platinum resistant HGSOC with high FRalpha e …
Mirvetuximab received accelerated approval by the United States Food and Drug Administration (FDA) in November 2022 based on the results of …
404 results