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CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition.
Andreu-Saumell I, Rodriguez-Garcia A, Mühlgrabner V, Gimenez-Alejandre M, Marzal B, Castellsagué J, Brasó-Maristany F, Calderon H, Angelats L, Colell S, Nuding M, Soria-Castellano M, Barbao P, Prat A, Urbano-Ispizua A, Huppa JB, Guedan S. Andreu-Saumell I, et al. Among authors: soria castellano m. Nat Commun. 2024 Apr 26;15(1):3552. doi: 10.1038/s41467-024-47799-z. Nat Commun. 2024. PMID: 38670972 Free PMC article.
Epitope spreading driven by the joint action of CART cells and pharmacological STING stimulation counteracts tumor escape via antigen-loss variants.
Conde E, Vercher E, Soria-Castellano M, Suarez-Olmos J, Mancheño U, Elizalde E, Rodriguez ML, Glez-Vaz J, Casares N, Rodríguez-García E, Hommel M, González-Aseguinolaza G, Uranga-Murillo I, Pardo J, Alkorta G, Melero I, Lasarte J, Hervas-Stubbs S. Conde E, et al. Among authors: soria castellano m. J Immunother Cancer. 2021 Nov;9(11):e003351. doi: 10.1136/jitc-2021-003351. J Immunother Cancer. 2021. PMID: 34810235 Free PMC article.