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189 results

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Page 1
SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation.
Wu X, Wang Y, Huang R, Gai Q, Liu H, Shi M, Zhang X, Zuo Y, Chen L, Zhao Q, Shi Y, Wang F, Yan X, Lu H, Xu S, Yao X, Chen L, Zhang X, Tian Q, Yang Z, Zhong B, Dong C, Wang Y, Bian XW, Liu X. Wu X, et al. Science. 2020 Aug 21;369(6506):984-988. doi: 10.1126/science.aba6652. Science. 2020. PMID: 32820125
Fate tracking and transcriptome assessment in reporter mice establishes SOSTDC1-expressing T(FH) cells as a distinct T cell population that develops after SOSTDC1(-) T(FH) cells and loses the ability to help B cells for antibody production. ...Mechanistically, SO …
Fate tracking and transcriptome assessment in reporter mice establishes SOSTDC1-expressing T(FH) cells as a distinct T cell populatio …
Role of Sostdc1 in skeletal biology and cancer.
Tong X, Zhu C, Liu L, Huang M, Xu J, Chen X, Zou J. Tong X, et al. Front Physiol. 2022 Oct 21;13:1029646. doi: 10.3389/fphys.2022.1029646. eCollection 2022. Front Physiol. 2022. PMID: 36338475 Free PMC article. Review.
Sostdc1 functions as an antagonist to bone morphogenetic protein (BMP), mediating BMP signaling. ...In the skeletal system, Sostdc1 is essential for bone metabolism, bone density maintenance, and fracture healing. ...
Sostdc1 functions as an antagonist to bone morphogenetic protein (BMP), mediating BMP signaling. ...In the skeletal system, Sostdc …
SOSTDC1 Nuclear Translocation Facilitates BTIC Maintenance and CHD1-Mediated HR Repair to Promote Tumor Progression and Olaparib Resistance in TNBC.
Deng Q, Qiang J, Liu C, Ding J, Tu J, He X, Xia J, Peng X, Li S, Chen X, Ma W, Zhang L, Jiang YZ, Shao ZM, Chen C, Liu S, Xu J, Zhang L. Deng Q, et al. Adv Sci (Weinh). 2024 Aug;11(29):e2306860. doi: 10.1002/advs.202306860. Epub 2024 Jun 12. Adv Sci (Weinh). 2024. PMID: 38864559 Free PMC article.
SOSTDC1 knockdown impairs homologous recombination (HR) repair, BTIC maintenance, and sensitized bulk cells and BTICs to Olaparib. Mechanistically, following Olaparib treatment, SOSTDC1 translocates to the nucleus in an importin-alpha dependent manner. Nuclear SO …
SOSTDC1 knockdown impairs homologous recombination (HR) repair, BTIC maintenance, and sensitized bulk cells and BTICs to Olaparib. Me …
SOSTDC1 downregulation in CD4(+) T cells confers protection against obesity-induced insulin resistance.
Li D, Zhu J, Zhang M, Shi Q, Guo R, Zhang D, Zheng P, Zhang H, Li G, Wu J, Sun G, Wen Q, Tan J, Liu Z, Liu X, Yang H, Lu H, Cao G, Yin Z, Wang Q. Li D, et al. Cell Rep. 2025 Apr 22;44(4):115496. doi: 10.1016/j.celrep.2025.115496. Epub 2025 Apr 1. Cell Rep. 2025. PMID: 40173040 Free article.
Mechanistically, SOSTDC1 disrupts the lipid balance in adipocytes by promoting lipogenesis and inhibiting lipolysis through the LRP5/6-beta-catenin pathway. Furthermore, T cell receptor (TCR) signaling significantly amplifies SOSTDC1 secretion in CD4(+) T cells. In …
Mechanistically, SOSTDC1 disrupts the lipid balance in adipocytes by promoting lipogenesis and inhibiting lipolysis through the LRP5/ …
Sostdc1 Regulates NK Cell Maturation and Cytotoxicity.
Millan AJ, Elizaldi SR, Lee EM, Aceves JO, Murugesh D, Loots GG, Manilay JO. Millan AJ, et al. J Immunol. 2019 Apr 15;202(8):2296-2306. doi: 10.4049/jimmunol.1801157. Epub 2019 Feb 27. J Immunol. 2019. PMID: 30814306
We identified roles for sclerostin domain-containing-1 (Sostdc1) in NK cell development and function. Sostdc1-knockout (Sostdc1 (-/-)) mice display a progressive accumulation of transitional NK cells (tNKs) (CD27(+)CD11b(+)) with age, indicating a partial dev …
We identified roles for sclerostin domain-containing-1 (Sostdc1) in NK cell development and function. Sostdc1-knockout (Sos …
Sostdc1 Suppression in the Absence of Sclerostin Potentiates Anabolic Action of Cortical Bone in Mice.
Choi RB, Hoggatt AM, Horan DJ, Rogers EZ, Loots GG, Robling AG. Choi RB, et al. J Bone Miner Res. 2023 May;38(5):765-774. doi: 10.1002/jbmr.4798. Epub 2023 Mar 22. J Bone Miner Res. 2023. PMID: 36891756 Free PMC article.
We looked for other candidates that might be co-inhibited along with sclerostin to potentiate the effects in the cortical compartment. Sostdc1 (Wise), like sclerostin and Dkk1, also binds and inhibits Lrp5/6 coreceptors to impair canonical Wnt signaling, but Sostdc1 …
We looked for other candidates that might be co-inhibited along with sclerostin to potentiate the effects in the cortical compartment. So …
SOSTDC1 acts as a tumor inhibitor in acute myeloid leukemia by downregulating the Wnt/beta-catenin pathway.
Li C, Wang M, Shi Y, Xin H. Li C, et al. Environ Toxicol. 2022 Aug;37(8):1934-1943. doi: 10.1002/tox.23540. Epub 2022 Apr 20. Environ Toxicol. 2022. PMID: 35442555
However, the function of SOSTDC1 in acute myeloid leukemia (AML) is unexplored. The goal of this work was to assess the possible role of SOSTDC1 in AML. Our data showed decreased SOSTDC1 level in bone marrow from AML patients, and patients with low levels of …
However, the function of SOSTDC1 in acute myeloid leukemia (AML) is unexplored. The goal of this work was to assess the possible role …
Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung.
Schupp JC, Adams TS, Cosme C Jr, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe'er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Schupp JC, et al. Circulation. 2021 Jul 27;144(4):286-302. doi: 10.1161/CIRCULATIONAHA.120.052318. Epub 2021 May 25. Circulation. 2021. PMID: 34030460 Free PMC article.
Beyond the broad cellular categories of lymphatic, capillary, arterial, and venous ECs, we found previously indistinguishable subpopulations; among venous EC, we identified 2 previously indistinguishable populations: pulmonary-venous ECs (COL15A1(neg)) localized to the lung paren …
Beyond the broad cellular categories of lymphatic, capillary, arterial, and venous ECs, we found previously indistinguishable subpopulations …
SOSTDC1 promotes invasion and liver metastasis in colorectal cancer via interaction with ALCAM/CD166.
Bartolomé RA, Pintado-Berninches L, Jaén M, de Los Ríos V, Imbaud JI, Casal JI. Bartolomé RA, et al. Oncogene. 2020 Sep;39(38):6085-6098. doi: 10.1038/s41388-020-01419-4. Epub 2020 Aug 15. Oncogene. 2020. PMID: 32801337 Free article.
SOSTDC1 inhibition of BMP4 maintains the expression of cancer stem cell traits, including SOX2 and NANOG. ...These experiments underscore the potential of SOSTDC1 as a therapeutic target in metastatic colorectal cancer....
SOSTDC1 inhibition of BMP4 maintains the expression of cancer stem cell traits, including SOX2 and NANOG. ...These experiments unders …
189 results